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Protein-Serine-Threonine Kinases
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Definition
: A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
Examples
Activin Receptors
;
AMP-Activated Protein Kinases
;
Bone Morphogenetic Protein Receptors
;
Calcium-Calmodulin-Dependent Protein Kinases
;
Casein Kinases
;
Cyclic Nucleotide-Regulated Protein Kinases
;
Cyclin-Dependent Kinases
;
DNA-Activated Protein Kinase
;
eIF-2 Kinase
;
G-Protein-Coupled Receptor Kinases
;
Glycogen Synthase Kinases
;
I-kappa B Kinase
;
Interleukin-1 Receptor-Associated Kinases
;
Lim Kinases
;
MAP Kinase Kinase Kinases
;
Mitogen-Activated Protein Kinase Kinases
;
Mitogen-Activated Protein Kinases
;
Oncogene Protein v-akt
;
p21-Activated Kinases
;
Phytochrome A
;
Positive Transcriptional Elongation Factor B
;
Proline-Directed Protein Kinases
;
Protein Kinase C
;
Proto-Oncogene Proteins c-akt
;
Proto-Oncogene Proteins c-bcr
;
Proto-Oncogene Proteins c-pim-1
;
Receptor-Interacting Protein Serine-Threonine Kinases
;
rho-Associated Kinases
;
Ribosomal Protein S6 Kinases
;
TOR Serine-Threonine Kinases
;
Vacuolar Sorting Protein VPS15
Other names
Serine-
Threonine Protein Kinases; Serine Threonine Protein Kinases; Serine Threonine Kinases; Serine Threonine Kinase; Protein Threonine Kinase; Protein Serine Threonine Kinases; Protein Serine Threonine Kinase; Protein Serine Kinase; Protein Kinases, Serine-
Threonine; Kinases, Serine-
Threonine Protein; Kinases, Serine-
Threonine; Kinases, Protein-
Serine-
Threonine; Kinase, Threonine; Kinase, Serine-
Threonine; Kinase, Serine; Kinase, Protein-
Threonine; Kinase, Protein-
Serine-
Threonine; Kinase, Protein-
Serine; Threonine Kinase; Serine-
Threonine Kinases
Substance
CAS Registry & name
Categories
Source
Drugs
*
ATM protein, Drosophila
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Drosophila Proteins
Cell Cycle Proteins.
Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):E656-64.
Rio1 protein, human
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
FEBS Lett. 2002 Jul 31;524(1-3):31-6.
SIK3 protein, mouse
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Mol Cell Endocrinol. 2004 Mar 31;217(1-2):109-12.
BIR1 protein, Arabidopsis
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Arabidopsis Proteins.
Plant J. 2011 Sep;67(6):1081-93.
Ulk4 protein, human
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Nat Genet. 2012 Jan;44(1):58-61.
polo-
like kinase 2, C elegans
EC 2.7.1.37
*Protein-Serine-Threonine Kinases
*Caenorhabditis elegans Proteins.
Dev Cell. 2011 Nov 15;21(5):934-47
Goodpasture antigen-
binding protein-
1, mouse
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
J Biol Chem. 2011 Oct 7;286(40):35030-43.
EIP1 protein, Arabidopsis
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Arabidopsis Proteins.
Plant Cell Physiol. 2011 Aug;52(8):1376-88.
CAST AWAY protein, Arabidopsis
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Arabidopsis Proteins.
Plant Physiol 2011 Aug;156(4):1837-50
DCLK protein, Xenopus
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Xenopus Proteins
Microtubule-Associated Proteins.
Endocrinology 2011 Jun;152(6):2321-9
AAK1 protein, rat
EC 2.7.1.37
*Protein-Serine-Threonine Kinases.
Chem Biol. 2011 Jul 29;18(7):891-906
DYF-
18 protein, C elegans
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Caenorhabditis elegans Proteins.
Dev Biol 2011 Sep 1;357(1):235-47
CoPK32 protein, Coprinopsis cinerea
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Biochim Biophys Acta. 2011 Jun;1810(6):620-9
LMTK3 protein, human
EC 2.7.11.1
*Membrane Proteins
*Protein-Serine-Threonine Kinases.
Nat Med. 2011 Jun;17(6):660-1
salt-
inducible kinase 3, Drosophila
EC 2.7.1.-
*Protein-Serine-Threonine Kinases
*Drosophila Proteins.
Cell. 2011 May 13;145(4):596-606
polo-
like kinase 4, Xenopus
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Xenopus Proteins.
J Cell Biol 2010 Nov 15;191(4):721-9
Pto-
interacting 1-
4 kinase, Arabidopsis
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Arabidopsis Proteins.
FEBS J 2011 Apr;278(7):1126-36
Pink1 protein, zebrafish
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
J Neurosci 2008 Aug 13;28(33):8199-207
CtkA protein, Helicobacter pylori
EC 2.7.11.1
*Bacterial Proteins
*Protein-Serine-Threonine Kinases.
Proc Natl Acad Sci U S A 2010 Dec 14;107(50):21418-23
KSR2 protein, human
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Mol Cell 2009 Jun 26;34(6):652-62
Hipk2 protein, zebrafish
EC 2.7.1.-
*Carrier Proteins
*Protein-Serine-Threonine Kinases.
Mol Cell Biol. 2011 Mar;31(5):955-70
ROP18 protein, Toxoplasma gondii
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
PLoS Biol 2010;8(12):e1000576
CG14217 protein, Drosophila
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Drosophila Proteins.
J Neurosci. 2011 Jan 19;31(3):1139-48
Drak protein, Drosophila
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Drosophila Proteins.
Mol Biol Cell 2010 Aug 15;21(16):2869-79
Nek10 protein, human
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Mol Cell Biol 2011 Jan;31(1):30-42
MASTL protein, human
EC 2.7.11.1
*Microtubule-Associated Proteins
*Protein-Serine-Threonine Kinases.
Cell Cycle 2010 Sep;9(17):3591-601
SRF3 protein, Arabidopsis
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Arabidopsis Proteins.
Nat Genet 2010 Dec;42(12):1135-9
DDK protein, S pombe
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Schizosaccharomyces pombe Proteins.
Mol Cell 2010 Nov 24;40(4):606-18
Pknk protein, Mycobacterium tuberculosis
EC 2.7.11.1
*Bacterial Proteins
*Protein-Serine-Threonine Kinases.
Microbiology 2010 Sep;156(Pt 9):2829-41
TNIK protein, rat
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
J Neurosci 2010 Nov 3;30(44):14786-94
FASTKD3 protein, mouse
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Biochem Biophys Res Commun. 2010 Oct 22;401(3):440-6
FASTKD3 protein, human
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Biochem Biophys Res Commun. 2010 Oct 22;401(3):440-6
CDKL3 protein, mouse
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Neurobiol Dis 2010 Sep;39(3):242-51
SNARK protein, mouse
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15541-6
Hrk1 protein, S pombe
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Schizosaccharomyces pombe Proteins.
Science. 2010 Oct 8;330(6001):239-43
haspin protein, Xenopus laevis
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Xenopus Proteins.
Science. 2010 Oct 8;330(6001):235-9
NDR2 protein kinase, mouse
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
J Biol Chem 2004 May 28;279(22):23806-12
NDR1 protein kinase, mouse
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Sci Signal 2010;3(126):ra47
WAG1 protein, Arabidopsis
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Arabidopsis Proteins.
Development 2010 Oct;137(19):3245-55
STK32B protein, human
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Eur J Hum Genet 2010 Jun;18(6):726-32
salt-
inducible kinase-
2, human
EC 2.7.1.-
*Protein-Serine-Threonine Kinases.
Cancer Cell. 2010 Aug 9;18(2):109-21
Smg1 protein, mouse
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Proc Natl Acad Sci U S A 2010 Jul 6;107(27):12186-91
CDKL5 protein, rat
EC 2.7.11.22
*Protein-Serine-Threonine Kinases.
Neurobiol Dis. 2010 Jun;38(3):414-24
MAP4K3 protein, Drosophila
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Drosophila Proteins.
Dev Biol. 2010 Aug 1;344(1):150-7
LRRK2 protein, zebrafish
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Zebrafish Proteins.
PLoS Genet 2010;6(4):e1000914
Atg2 protein, Drosophila
EC 2.7.1.37
*Protein-Serine-Threonine Kinases
*Drosophila Proteins.
Nature. 2010 Jun 24;465(7301):1093-6
Oca2 protein, S pombe
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Schizosaccharomyces pombe Proteins.
Mol Cell Biol 2010 Jul;30(13):3396-410
FAST protein, mouse
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
J Immunol 2010 May 1;184(9):5325-32
polo-
like kinase 5, human
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Nucleic Acids Res 2010 May;38(9):2931-43
polo-
like kinase 5, mouse
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Nucleic Acids Res 2010 May;38(9):2931-43
HUNK protein, human
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Proc Natl Acad Sci U S A 2010 Feb 9;107(6):2622-7
GAK protein, zebrafish
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Zebrafish Proteins.
BMC Dev Biol 2010;10:7
CORYNE protein, Arabidopsis
EC 2.7.11.1
*Receptors, Cell Surface
*Protein-Serine-Threonine Kinases.
Plant Physiol 2010 Jan;152(1):166-76
Unc-
82 protein, C elegans
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Caenorhabditis elegans Proteins.
Genetics 2010 Jan;184(1):79-90
Stk40 protein, mouse
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Proc Natl Acad Sci U S A 2010 Jan 26;107(4):1402-7
Nek4 protein, human
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Cancer Res 2010 Feb 1;70(3):1033-41
LRRK2 protein, rat
EC 2.7.1.37
*Protein-Serine-Threonine Kinases
Parkinson Disease.
Neurosci Lett. 2010 Jan 4;468(2):120-4
ULK3 protein, human
EC 2.7.11.1
*Protein-Serine-Threonine Kinases.
Exp Cell Res 2010 Feb 15;316(4):627-37
Stk1 protein, Staphylococcus aureus
EC 2.7.11.1
*Protein-Serine-Threonine Kinases
*Virulence Factors.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 Nov 1;65(Pt 11):1187-9
STRAD protein, C elegans
0
*Caenorhabditis elegans Proteins
Protein-Serine-Threonine Kinases.
Development 2010 Jan;137(1):93-102
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