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| The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
| coord IM with specific DNA (IM)
See Also Pyrimidine Dimers | Other names Nucleotide Excision Repair; Repairs, Base Excision; Repair, Excision; Repair, Base Excision; Nucleotide Excision Repairs; Excision Repairs; Excision Repair, Nucleotide; Excision Repair, Base; Base Excision Repairs; Excision Repair; Base Excision Repair; Nucleotide Excision Repair
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| |
| Substance | CAS Registry & name | Categories | Source
|
| MLH1 protein, human
| 0
|
DNA Repair *Carrier Proteins *Nuclear Proteins.
|
|
| Ku autoantigen
| 0
|
*DNA-Binding Proteins *Antigens, Nuclear DNA Repair.
|
J Biol Chem 1986;261(5):2274
|
| XRCC5 protein, human
| 0
|
*DNA Helicases DNA Repair Leucine Zippers.
|
EMBO J 1997 Jun 2;16(11):3172-84
|
X-ray repair cross complementing protein 1
| 0
|
*DNA-Binding Proteins DNA Repair.
|
Mol Cell Biol 1994 Jan;14(1):68-76
|
| ATR protein, human
| EC 2.7.1.-
|
*Protein-Serine-Threonine Kinases *Cell Cycle Proteins DNA Repair.
|
Genes Dev 1996 Oct 1;10(19):2423-37; Proc Natl Acad Sci U S A 1996 Apr 2;93(7):2850-5
|
G-T mismatch-binding protein
| 0
|
*DNA-Binding Proteins Zebrafish Proteins DNA Repair Base Pair Mismatch.
|
Science 1995 Jun 30;268(5219):1912-4
|
| APEX1 protein, human
| EC 4.2.99.18
|
*DNA-(Apurinic or Apyrimidinic Site) Lyase DNA Repair.
|
Proc Natl Acad Sci U S A 1994 Jan 4;91(1):23-7
|
| ERCC1 protein, human
| EC 3.1.-
|
*DNA-Binding Proteins *Endonucleases DNA Repair.
|
Nucleic Acids Res 1991;19(20):5633
|
| NTH protein, E coli
| EC 3.1.25.1
|
*Escherichia coli Proteins *Deoxyribonuclease (Pyrimidine Dimer) DNA Repair.
|
J Bacteriol 1997 Jun;179(11):3783-5
|
| Rad30 protein
| EC 2.7.7.7
|
*DNA-Directed DNA Polymerase DNA Repair Xeroderma Pigmentosum.
|
Mol Gen Genet 1998 Apr;257(6):686-92
|
| MRE11 protein, S cerevisiae
| EC 3.1.-
|
*Endodeoxyribonucleases *Exodeoxyribonucleases *Saccharomyces cerevisiae Proteins DNA Repair.
|
Genetics 1995 Apr;139(4):1521-32
|
| MEC1 protein, S cerevisiae
| 0
|
*Saccharomyces cerevisiae Proteins DNA Repair Recombination, Genetic.
|
Nucleic Acids Res 1994 Aug 11;22(15):3104-12
|
3-methyladenine-DNA glycosylase
| EC 3.2.2.-
|
*DNA Glycosylases DNA Repair.
|
Biochemistry 17(11):2110;1978; Biochemistry 18(5):911;1979; Nature 259(5538):64;1976
|
| RuvB protein, Bacteria
| 0
|
*Bacterial Proteins Adenosine Triphosphatases DNA Repair DNA Helicases.
|
J Bacteriol 1989;171(10):5276
|
| PMS2 protein, human
| EC 3.6.1.-
|
*Adenosine Triphosphatases *DNA-Binding Proteins *DNA Repair Enzymes DNA Repair Neoplasm Proteins Base Pair Mismatch.
|
Cell 1995 Jul 28;82(2):309-19; Nature 1994 Sep 1;371(6492):75-80
|
| MSH2 protein, fungal
| EC 3.6.1.3
|
*Fungal Proteins *MutS Homolog 2 Protein DNA Repair Base Pair Mismatch.
|
Genetics 1992 Dec;132(4):963-73
|
| XPC protein, human
| 156533-34-5
|
*DNA-Binding Proteins DNA Repair Transglutaminases Xeroderma Pigmentosum.
|
EMBO J 1994 Apr 15;13(8):1831-43
|
X-ray repair cross complementing protein 3
| 0
|
*DNA-Binding Proteins DNA Repair.
|
Cancer Res 1998 Feb 15;58(4):604-8
|
| UvrB protein, E coli
| 0
|
*DNA Helicases *Escherichia coli Proteins Adenosine Triphosphatases DNA Repair.
|
Nucleic Acids Res 1988;16(22):10891
|
DNA-3-methyladenine glycosidase II
| EC 3.2.2.21
|
*DNA Glycosylases DNA Repair.
|
Proc Natl Acad Sci U S A 1981 Feb;78(2):856-60
|
| RAD1 protein, S cerevisiae
| EC 3.1.-
|
*DNA-Binding Proteins *Endonucleases *Saccharomyces cerevisiae Proteins DNA Repair.
|
FEBS Lett 1991;283(2):203
|
DNA excision repair protein ERCC-5
| 0
|
*DNA-Binding Proteins *Endonucleases *Nuclear Proteins *Transcription Factors DNA Repair Xenopus Proteins Drosophila Proteins.
|
Nature 1993 May 13;363(6425):114-5
|
| MSH2 protein, S cerevisiae
| EC 3.6.1.3
|
DNA Repair Base Pair Mismatch *Saccharomyces cerevisiae Proteins *MutS Homolog 2 Protein.
|
|
| RAD54 protein, S cerevisiae
| 0
|
*Saccharomyces cerevisiae Proteins DNA Repair.
|
Yeast 1992 May;8(5):385-95
|
| XRCC4 protein, human
| 0
|
*DNA-Binding Proteins DNA Repair.
|
Curr Top Microbiol Immunol 1996;217:143-50
|
| xeroderma pigmentosum group F protein
| 0
|
*DNA-Binding Proteins DNA Repair.
|
J Biol Chem 1995 Sep 29;270(39):22657-60
|
| MCD1 protein, S cerevisiae
| 0
|
DNA Repair *Nuclear Proteins *Phosphoproteins *Cell Cycle Proteins *Saccharomyces cerevisiae Proteins.
|
|
| ERCC6 protein, human
| EC 3.6.1.-
|
*DNA Helicases *DNA Repair Enzymes Cockayne Syndrome DNA Repair.
|
Cell 1992 Dec 11;71(6):939-53
|
| MSH6 protein, S cerevisiae
| 0
|
*DNA-Binding Proteins *Saccharomyces cerevisiae Proteins DNA Repair Base Pair Mismatch.
|
Genes Dev 1996 Feb 15;10(4):407-20
|
XPBC-ERCC-3 protein
| 146045-44-5
|
*DNA Helicases *DNA-Binding Proteins DNA Repair DNA Helicases.
|
Carcinogenesis 1991;12(12):2361
|
| RAD23A protein, human
| 156533-33-4
|
*DNA-Binding Proteins *DNA Repair Enzymes DNA Repair.
|
EMBO J 1994 Apr 15;13(8):1831-43
|
| MLH1 protein, fungal
| 0
|
*Fungal Proteins DNA Repair Base Pair Mismatch.
|
Science 1994 Aug 19;265(5175):1091-3
|
| Apex1 protein, mouse
| EC 4.2.99.18
|
DNA Repair *DNA-(Apurinic or Apyrimidinic Site) Lyase.
|
|
methyl-directed mismatch repair protein, E coli
| EC 3.1.21.-
|
*DNA-Binding Proteins *Endodeoxyribonucleases *Escherichia coli Proteins *DNA Repair Enzymes DNA Repair.
|
Gene 1988;74(1):211
|
| RAD23 protein, S cerevisiae
| 0
|
DNA Repair *DNA-Binding Proteins *Saccharomyces cerevisiae Proteins.
|
|
| RAD2 protein, S cerevisiae
| 103371-12-6
|
*DNA-Binding Proteins *Endodeoxyribonucleases *Saccharomyces cerevisiae Proteins DNA Repair Saccharomyces cerevisiae.
|
Yeast 1992 Feb;8(2):121-32
|
| RAD23 protein, fungal
| 0
|
*DNA-Binding Proteins *Fungal Proteins DNA Repair.
|
Mutat Res 1996 Feb 15;362(2):155-65
|
| DCLRE1C protein, human
| 0
|
DNA Repair *Nuclear Proteins.
|
Cell 2001 Apr 20;105(2):177-86
|
| Pms2 protein, mouse
| EC 3.6.1.-
|
DNA Repair Neoplasm Proteins Base Pair Mismatch *Adenosine Triphosphatases *DNA-Binding Proteins *DNA Repair Enzymes.
|
|
| RHP51 protein, S pombe
| 0
|
*Schizosaccharomyces pombe Proteins *Rad51 Recombinase DNA Repair Schizosaccharomyces.
|
Nucleic Acids Res 1993 Sep 25;21(19):4586-91
|
| recJ protein, Bacteria
| EC 3.1.11.-
|
*Bacterial Proteins *Exodeoxyribonucleases DNA Repair.
|
Biochimie 1991;73(2-3)313
|
| Atr protein, mouse
| EC 2.7.1.-
|
DNA Repair *Protein-Serine-Threonine Kinases *Cell Cycle Proteins.
|
|
| EXO1 protein, human
| EC 3.1.-
|
*Exodeoxyribonucleases *DNA Repair Enzymes DNA Repair.
|
Nucleic Acids Res 1998 Aug 15;26(16):3762-8
|
| MSH3 protein, fungal
| 0
|
*DNA-Binding Proteins *Fungal Proteins DNA Repair Base Pair Mismatch Saccharomyces cerevisiae.
|
Mol Gen Genet 1993 May;239(1-2):97-108; Yeast 1991 Dec;7(9):981-8
|
| Ercc1 protein, mouse
| EC 3.1.-
|
DNA Repair *DNA-Binding Proteins *Endonucleases.
|
|
| Apn1 protein, S cerevisiae
| EC 3.1.25.-
|
*Endodeoxyribonucleases *Saccharomyces cerevisiae Proteins DNA Repair Saccharomyces cerevisiae.
|
J Biol Chem 1993 Sep 25;268(27):20533-9
|
| DNA alkyltransferase
| EC 2.5.1.-
|
*Alkyl and Aryl Transferases DNA Repair.
|
Biochim Biophys Acta 1987;908(1):60
|
| PMS1 protein, S cerevisiae
| 0
|
*Carrier Proteins *Saccharomyces cerevisiae Proteins Base Pair Mismatch DNA Repair.
|
Science 1994 Aug 19;265(5175):1091-3
|
| RecJ protein, E coli
| EC 3.1.11.-
|
DNA Repair *Exodeoxyribonucleases *Escherichia coli Proteins.
|
|
| Atr protein, Xenopus
| EC 2.7.1.-
|
DNA Repair *Protein-Serine-Threonine Kinases *Cell Cycle Proteins *Xenopus Proteins.
|
|
| haywire protein, Drosophila
| 148998-67-8
|
*DNA-Binding Proteins *Drosophila Proteins DNA Repair.
|
Cell 1992 Dec 11;71(6):925-37
|
| RAD5 protein, S cerevisiae
| 148349-40-0
|
*Adenosine Triphosphatases *Saccharomyces cerevisiae Proteins DNA Repair.
|
Mol Cell Biol 1992 Sep;12(9):3807-18
|
| APTX protein, human
| 0
|
DNA Repair Zinc Fingers *DNA-Binding Proteins *Nuclear Proteins.
|
Nat Genet 2001 oct;29(2):184-8
|
| rad1 protein, S pombe
| EC 3.1.-
|
DNA Repair *DNA-Binding Proteins *Endonucleases *Schizosaccharomyces pombe Proteins.
|
|
| Xpc protein, mouse
| 0
|
DNA Repair *DNA-Binding Proteins.
|
|
| RAD16 protein, S cerevisiae
| EC 3.6.1.3
|
*Adenosine Triphosphatases *Saccharomyces cerevisiae Proteins DNA Repair Saccharomyces cerevisiae.
|
Yeast 1992 May;8(5):385-95
|
| vsr endonuclease
| EC 3.1.21.-
|
*Endodeoxyribonucleases DNA Repair Base Pair Mismatch.
|
Nature 1991;353(6346):776
|
| RAD7 protein, S cerevisiae
| 0
|
*DNA-Binding Proteins *Saccharomyces cerevisiae Proteins Adenosine Triphosphatases DNA Repair.
|
Gene 1990;87(2):157
|
| RAD25 protein, Fungus
| 147388-16-7
|
*DNA Helicases *Fungal Proteins DNA Repair Protein Biosynthesis.
|
Cell 1992 Jun 12;69(6):1031-42
|
| RAD54L protein, human
| 0
|
*Nuclear Proteins Adenosine Triphosphatases DNA Repair.
|
Curr Biol 1996 Jul 1;6(7):828-38
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