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Receptors, CCR2

More information in Books or onNLM PubMed
Definition: CCR receptors with specificity for CHEMOKINE CCL2 and several other CCL2-related chemokines. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; MACROPHAGES; BASOPHILS; and NK CELLS.      Other names Receptors, MCP-1; Receptors, CCR2b; Receptor-2, CC Chemokine; Receptor, MCP-1; Receptor, CCR2b; Receptor, CCR2a; Receptor, CCR2; Receptor, CCR-2A MCP-1; Receptor CCR-2A, MCP-1; MCP-1 Receptor, CCR-2A; MCP 1 Receptors; MCP 1 Receptor CCR 2A; MCP 1 Receptor 2B; MCP 1 Receptor; Chemokine Receptor-2, CC; CCR 2A MCP 1 Receptor; Monocyte Chemoattractant Protein 1 Receptor; MCP-1RB; MCP-1RA; MCP-1 Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-(3-(3-chloro-4-fluorophenyl)acryloyl)-1-(3-(4-hydroxy-6-azaspiro(2.5)oct-6-yl)propyl)-3-methylpiperazin-2-one  0   *Cinnamates *Piperazines Receptors, CCR2/antagonists & inhibitors. Kidney Int 2011 Jul;80(1):68-78
((1-isopropyl-3-(3-methoxy-tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methanone)  0   *Piperazines *Pyridazines Receptors, CCR2/antagonists & inhibitors. Bioorg Med Chem Lett 2011 May 1;21(9):2626-30
N-(3-isopropyl-3-((4-(4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)carbonyl)cyclopentyl)-3-methoxytetrahydro-2H-pyran-4-amine  0   *Piperazines *Pyrans Receptors, CCR5/antagonists & inhibitors Receptors, CCR2/antagonists & inhibitors. Bioorg Med Chem Lett 2011 Mar 1;21(5):1442-6
AZ 889  0   *Piperazines Receptors, CCR2/antagonists & inhibitors. Mol Pain 2010;6:90
1,5-anhydro-2,3-dideoxy-3-((3-isopropyl-3-((4-(4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)carbonyl)cyclopentyl)amino)-4-O-methylpentitol  0   *Piperazines *Pyridines Receptors, CCR2/antagonists & inhibitors. J Immunol 2011 Jan 1;186(1):508-15
N-(3-(1-methylethyl)-3-((3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)carbonyl)cyclopentyl)tetrahydro-2H-pyran-4-amine  0   *Naphthyridines Receptors, CCR2/antagonists & inhibitors. Arterioscler Thromb Vasc Biol 2010 Feb;30(2):253-9
N-(carbamoylmethyl)-3-trifluoromethyl benzamido-4-chlorobenzyl 3-aminopyrrolidine  0   *Benzamides *Pyrrolidines Receptors, CCR2/antagonists & inhibitors. Mol Pharmacol 2009 Jun;75(6):1325-36
Ccr2 protein, rat  0   *Receptors, CCR2.
Ccr2 protein, mouse  0   *Receptors, CCR2.
CCR2 protein, human  0   *Receptors, CCR2.
TAK-652  0   *Imidazoles Receptors, CCR5/antagonists & inhibitors Receptors, CCR2/antagonists & inhibitors. Antimicrob Agents Chemother. 2005 Nov;49(11):4584-91

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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