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Receptors, CCR2
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Definition
: CCR receptors with specificity for CHEMOKINE CCL2 and several other CCL2-related chemokines. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; MACROPHAGES; BASOPHILS; and NK CELLS.
Other names
Receptors, MCP-
1; Receptors, CCR2b; Receptor-
2, CC Chemokine; Receptor, MCP-
1; Receptor, CCR2b; Receptor, CCR2a; Receptor, CCR2; Receptor, CCR-
2A MCP-
1; Receptor CCR-
2A, MCP-
1; MCP-
1 Receptor, CCR-
2A; MCP 1 Receptors; MCP 1 Receptor CCR 2A; MCP 1 Receptor 2B; MCP 1 Receptor; Chemokine Receptor-
2, CC; CCR 2A MCP 1 Receptor; Monocyte Chemoattractant Protein 1 Receptor; MCP-
1RB; MCP-
1RA; MCP-
1 Receptors
Substance
CAS Registry & name
Categories
Source
Drugs
*
4-
(3-
(3-
chloro-
4-
fluorophenyl)acryloyl)-
1-
(3-
(4-
hydroxy-
6-
azaspiro(2.5)oct-
6-
yl)propyl)-
3-
methylpiperazin-
2-
one
0
*Cinnamates
*Piperazines
Receptors, CCR2/antagonists & inhibitors.
Kidney Int 2011 Jul;80(1):68-78
((1-
isopropyl-
3-
(3-
methoxy-
tetrahydro-
2H-
pyran-
4-
ylamino)cyclopentyl)(4-
(5-
(trifluoromethyl)pyridazin-
3-
yl)piperazin-
1-
yl)methanone)
0
*Piperazines
*Pyridazines
Receptors, CCR2/antagonists & inhibitors.
Bioorg Med Chem Lett 2011 May 1;21(9):2626-30
N-
(3-
isopropyl-
3-
((4-
(4-
(trifluoromethyl)pyridin-
2-
yl)piperazin-
1-
yl)carbonyl)cyclopentyl)-
3-
methoxytetrahydro-
2H-
pyran-
4-
amine
0
*Piperazines
*Pyrans
Receptors, CCR5/antagonists & inhibitors
Receptors, CCR2/antagonists & inhibitors.
Bioorg Med Chem Lett 2011 Mar 1;21(5):1442-6
AZ 889
0
*Piperazines
Receptors, CCR2/antagonists & inhibitors.
Mol Pain 2010;6:90
1,5-
anhydro-
2,3-
dideoxy-
3-
((3-
isopropyl-
3-
((4-
(4-
(trifluoromethyl)pyridin-
2-
yl)piperazin-
1-
yl)carbonyl)cyclopentyl)amino)-
4-
O-
methylpentitol
0
*Piperazines
*Pyridines
Receptors, CCR2/antagonists & inhibitors.
J Immunol 2011 Jan 1;186(1):508-15
N-
(3-
(1-
methylethyl)-
3-
((3-
(trifluoromethyl)-
7,8-
dihydro-
1,6-
naphthyridin-
6(5H)-
yl)carbonyl)cyclopentyl)tetrahydro-
2H-
pyran-
4-
amine
0
*Naphthyridines
Receptors, CCR2/antagonists & inhibitors.
Arterioscler Thromb Vasc Biol 2010 Feb;30(2):253-9
N-
(carbamoylmethyl)-
3-
trifluoromethyl benzamido-
4-
chlorobenzyl 3-
aminopyrrolidine
0
*Benzamides
*Pyrrolidines
Receptors, CCR2/antagonists & inhibitors.
Mol Pharmacol 2009 Jun;75(6):1325-36
Ccr2 protein, rat
0
*Receptors, CCR2.
Ccr2 protein, mouse
0
*Receptors, CCR2.
CCR2 protein, human
0
*Receptors, CCR2.
TAK-
652
0
*Imidazoles
Receptors, CCR5/antagonists & inhibitors
Receptors, CCR2/antagonists & inhibitors.
Antimicrob Agents Chemother. 2005 Nov;49(11):4584-91