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Diketopiperazines

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Definition: Piperazines with two keto oxygens.     
Pharmacological Action Anti-Bacterial Agents
Examples Razoxane 		Other names Diketopiperazine Compounds; Pyrrolopiperazinediones; Pyrrolodiketopiperazines; Piperazinediones; Diketopiperazine Ion (1-); Diketopiperazine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-(3-benzoylbenzylidene)-6-((5-tert-butyl-1H-imidazol-4-yl)methylene)piperazine-2,5-dione  0   *Imidazoles *Diketopiperazines. J Med Chem. 2012 Feb 9;55(3):1056-71.
3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(2,5-difluorobenzylidene)piperazine-2,5-dione  0   *Imidazoles *Diketopiperazines. J Med Chem. 2012 Feb 9;55(3):1056-71.
cyclo-(4-S-hydroxy-R-proline-R-isoleucine)  0   *Peptides, Cyclic *Diketopiperazines. Mar Drugs. 2011;9(11):2469-78
3-(2,3-dihydro-1H-inden-2-yl)-1-(1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl)-6-(1-methylpropyl)-2,5-piperazinedione  0   *Morpholines *Diketopiperazines Oxytocin/antagonists & inhibitors. J Med Chem. 2012 Jan 26;55(2):783-96.
glionitrin B  0   *Diketopiperazines. J Nat Prod. 2011 Oct 28;74(10):2309-12
pestalazine A  0   *Indole Alkaloids *Diketopiperazines. Nat Prod. 2008 Nov;71(11):1861-5
4-(4-((1-butyl-3-(cyclohexyl(hydroxy)methyl)-2,5-dioxo-1,4,9-triazaspiro(5.5)undec-9-yl)methyl)phenoxy)benzoic acid  0   *Benzoic Acids *Diketopiperazines Receptors, CCR5/antagonists & inhibitors. Bioorg Med Chem 2011 Jul 1;19(13):4028-42
protubonine B  0   *Diketopiperazines Alkaloids. J Nat Prod. 2011 May 27;74(5):1284-7
protubonine A  0   *Diketopiperazines Alkaloids. J Nat Prod. 2011 May 27;74(5):1284-7
nocardioazine B  0   *Diketopiperazines. Org Lett. 2011 May 20;13(10):2770-3
nocardioazine A  0   *Diketopiperazines. Org Lett. 2011 May 20;13(10):2770-3
deoxyapoaranotin  0   *Disulfides *Diketopiperazines. J Appl Microbiol 2011 Jan;110(1):304-13
acetylapoaranotin  0   *Disulfides *Diketopiperazines. J Appl Microbiol 2011 Jan;110(1):304-13
bacillusamide A  0   *Diketopiperazines. Chem Pharm Bull (Tokyo). 2011;59(1):106-8
bacillusamide B  0   *Diketopiperazines. Chem Pharm Bull (Tokyo). 2011;59(1):106-8
pestalazine B  0   *Indole Alkaloids *Diketopiperazines. Org Biol Chem 2010 Nov 21;8(22):5179-86
7-O-methylvariecolortide A  0   *Indole Alkaloids *Diketopiperazines. Nat Prod Commun 2010 Oct;5(10):1583-6
dimerumic acid  0   *Hydroxamic Acids *Diketopiperazines. Free Radic Biol Med 2000 Mar 15;28(6):999-1004
ent-cycloechinulin  0   *Diketopiperazines. Chem Pharm Bull (Tokyo). 2010;58(5):717-9
novoamauromine  0   *Diketopiperazines. Chem Pharm Bull (Tokyo). 2010;58(5):717-9
1,4-N,N-(phenylethyl)piperazine-2,5-dione  0   *Diketopiperazines. Amino Acids 2010 Mar;38(3):829-37
glionitrin A  0   *Diketopiperazines. J Nat Prod. 2009 Feb 27;72(2):248-52
erythrochelin  0   *Oligopeptides *Diketopiperazines. Chem Biol. 2010 Feb 26;17(2):160-73
eleutherazine A  0   *Diketopiperazines. J Asian Nat Prod Res. 2010 Jan;12(1):51-5
eleutherazine B  0   *Diketopiperazines. J Asian Nat Prod Res. 2010 Jan;12(1):51-5
5-(aminomethyl)piperazine-2,3-dione  0   *Diketopiperazines Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors. Bioorg Med Chem Lett 2009 Jul 15;19(14):3832-5
3-(aminomethyl)piperazine-2,5-dione  0   *Diketopiperazines Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors. Bioorg Med Chem Lett 2009 Jul 15;19(14):3832-5
naseseazine B  0   *Diketopiperazines. Org Lett. 2009 Sep 3;11(17):3862-5
naseseazine A  0   *Diketopiperazines. Org Lett. 2009 Sep 3;11(17):3862-5
6,6'-bis(chloromethyl)-1,1',4,4'-tetramethyl-3,3'-(p-phenylenedimethylene)bis(piperazine-2,5-dione)  0   *Diketopiperazines. Acta Crystallogr C. 2009 Aug;65(Pt 8):o381-4
cyclo-L-glycyl-L-2-allylproline  0   *Peptides, Cyclic *Diketopiperazines. Br J Pharmacol 2009 Feb;156(4):662-72
DKP101516  0   *Peptides, Cyclic *Diketopiperazines. Exp Neurol 2008 Dec;214(2):331-40
PJ 157  0   *Diketopiperazines. J Asian Nat Prod Res 2007 Apr-Aug;9(3-5):197-201
PJ 147  0   *Diketopiperazines. J Asian Nat Prod Res 2007 Apr-Aug;9(3-5):197-201
NPI 2358  0   *Diketopiperazines. Anticancer Drugs 2006 Jan;17(1):25-31
phenylahistin  0   *Diketopiperazines. J Antibiot (Tokyo) 1999 Feb;52(2):134-41
desferricoprogen  100811-54-9   *Hydroxamic Acids *Diketopiperazines Siderophores. J Bacteriol 1986;165(1):283

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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