encyclopedia of medical concepts
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Coformycin
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Definition
: A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.
an enzyme inhib & antineoplastic antibiotic
Pharmacological Action
Antibiotics, Antineoplastic
;
Enzyme Inhibitors
;
Immunosuppressive Agents
Examples
Pentostatin
Substance
CAS Registry & name
Categories
Source
Drugs
*
carbocyclic coformycin
0
Coformycin/*analogs & derivatives.
Plant Physiol 1997 May;114(1):119-29
3,6,7,8-
tetrahydro-
3-
((2-
hydroxyethoxy)methyl)imidazo(4,5-
d)(1,3)diazepin-
8-
ol
86646-88-0
Coformycin/*analogs & derivatives
Adenosine Deaminase/antagonists & inhibitors.
J Med Chem 1983;26(10):1478
isocoformycin
67187-35-3 imidazo(4,5-
d)(1,3)diazepin-
7-
ol, 3,4,7,8-
tetrahydro-
3-
beta-
D-
ribofuranosyl
*Coformycin
Isomerism.
J Antibiot (Tokyo) 1980;33(3):303