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Complement Inactivating Agents

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Definition: Compounds that negatively regulate the cascade process of COMPLEMENT ACTIVATION. Uncontrolled complement activation and resulting cell lysis is potentially dangerous for the host.  do not confuse with COMPLEMENT INACTIVATOR PROTEINS    Other names Inhibiting Agents, Complement; Inactivating Agents, Complement; Agents, Complement Inhibiting; Agents, Complement Inactivating; Complement Inhibiting Agents; Complement Cytolysis Inhibiting Agents
Substances having this pharmacologic action: nafamostat; K 76 carboxylic acid; Complement C4b-Binding Protein; Complement C1 Inhibitor Protein; Complement Factor H; Complement Factor I; Antigens, CD59; Complement Inactivator Proteins; Complement C1 Inactivator Proteins; Complement C3 Nephritic Factor; Complement C3b Inactivator Proteins; cobra venom factor; C5a peptidase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
soluble complement inhibitor 1  150428-53-8   *Receptors, Complement Recombinant Proteins Complement Inactivating Agents. Eur J Pharmacol 1993 Jun 4;236(3):477-81

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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