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| Muromonab-CD3 |
| Anti-CD3 monoclonal antibody that exerts immunosuppressive effects by inducing peripheral T-cell depletion and modulation of the T-cell receptor complex (CD3/Ti). This biochemically purified IMMUNOGLOBULIN G is obtained through the fusion of mouse myeloma cells to lymphocytes from immunized animals to produce hybridomas that secrete specific antibodies to the T3 (CD3) antigens of human T-lymphocytes. It is often used as an IMMUNOSUPPRESSIVE AGENTS in TRANSPLANTATION.
| do not coordinate with ANTIBODY FORMATION for biosyn
Pharmacological Action Immunologic Factors; Immunosuppressive Agents | Other names Monoclonal Antibody OKT3; Ortho Brand of Muromonab CD3; Muromonab CD3; Janssen Brand of Muromonab CD3; Cilag Brand of Muromonab CD3; Orthoclone OKT3; Ortho Brand of Muromonab-CD3; OKT3; Janssen Brand of Muromonab-CD3; Cilag Brand of Muromonab-CD3; Monoclonal Antibody OKT3Drugs* :
ORTHOCLONE OKT3
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| Substance | CAS Registry & name | Categories | Source | Drugs*
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monoclonal antibody huOKT3(Ala-Ala)
| 0
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*Muromonab-CD3.
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Transplant Proc 1998 Jun;30(4):1369-70
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hOKT3gamma1(Ala-Ala)
| 0
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*Muromonab-CD3.
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Diabetes 2005 Jun;54(6):1763-9
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| hOKT3 gamma4
| 0
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*Muromonab-CD3 Mitogens.
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Cancer Res 1999 May 1;59(9):2096-101
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