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Plicamycin

More information in Books or onNLM PubMed
Definition: A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.     
Pharmacological Action Antibiotics, Antineoplastic; Fluorescent Dyes; Nucleic Acid Synthesis Inhibitors; Protein Synthesis Inhibitors
Other names Mithramycin; Aureolic Acid; Acid, Aureolic; MitramycinDrugs* : MITHRACIN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
mithramycin SK  0   Plicamycin/*analogs & derivatives. Nucleic Acids Res 2007;35(7):2215-26
premithramycinone G  0   Plicamycin/*analogs & derivatives. Angew Chem Int Ed Engl. 2006 Aug 25;45(34):5685-9
SDK compound  0   Plicamycin/*analogs & derivatives. Nucleic Acids Res. 2006;34(6) (dup#1):1721-34
bis(mithromycin)iron(II)  0   *Ferrous Compounds Plicamycin/*analogs & derivatives. Nucleic Acids Res 2005;33(4):1352-61
durhamycin B  0   Plicamycin/*analogs & derivatives. J Nat Prod. 2002 Aug;65(8):1091-5
durhamycin A  0   Plicamycin/*analogs & derivatives. J Nat Prod. 2002 Aug;65(8):1091-5
mtrY protein, Streptomyces argillaceus  0   *Bacterial Proteins Plicamycin. FEMS Microbiol Lett 2000 May 1;186(1):61-5
mtrX protein, Streptomyces argillaceus  0   *Bacterial Proteins Plicamycin. FEMS Microbiol Lett 2000 May 1;186(1):61-5
UCH 9  0   Plicamycin/*analogs & derivatives. Nucleic Acids Res 1998 Feb 1;26(3):744-55
mithramycin A  97666-60-9   Plicamycin/*analogs & derivatives. Biochemistry 1990;29(39):9294
variamycin  12677-11-1 3(C)-demethyl-4(C)-O-methylmithramycin  Plicamycin/*analogs & derivatives. Antibiotiki 19(8):687;1974; Antibiotiki 20(11):1032;1975; Antibiotiki 20(2):154;1975; Antibiotiki 20(8):705;1975; Antibiotiki 23(2):103;1978; Antibiotiki 23(4):349;1978; J Chem Soc Perkin I 6:643;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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