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Lignans 
A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)  do not confuse with LIGNIN, also found in plants    Other names Neolignans; Neolignans
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2,3-bis(3'-hydroxybenzyl)butyrolactone  76543-15-2 2(3H)-Furanone, dihydro-3,4-bis((3-hydroxyphenyl)methyl)  *Lignans 4-Butyrolactone/*analogs & derivatives. 
Pharma Action Phytoestrogens 		FEBS Lett 1980;122(1):49; Nature 1980;287(5784):738
magnolol  528-43-8   *Biphenyl Compounds *Lignans Nitric Oxide Synthase/antagonists & inhibitors. 
Pharma Action Anti-Arrhythmia Agents ; Anti-Inflammatory Agents, Non-Steroidal ; Platelet Aggregation Inhibitors 		Jpn J Pharmacol 25(5):605;1973; Yakugaku Zasshi 93(4):429;1973
honokiol  35354-74-6 3,5'-diallyl-4,2'-dihydroxybiphenyl  *Biphenyl Compounds *Lignans Drugs, Chinese Herbal Nitric Oxide Synthase/antagonists & inhibitors. 
Pharma Action Anti-Arrhythmia Agents ; Anti-Infective Agents ; Antineoplastic Agents, Phytogenic ; Central Nervous System Depressants ; Enzyme Inhibitors ; Gastrointestinal Agents ; Anti-Anxiety Agents ; Anti-Allergic Agents 		J Pharm Soc Jap 93(4):429;1973; Jpn J Pharmacol 25(5):605;1975
sesamin  607-80-7   *Dioxoles *Lignans Sesame Oil. 
Pharma Action Anticholesteremic Agents ; Antihypertensive Agents ; Antioxidants 		Contact Dermatitis 1987;17(3):133
sulfated glycoprotein p50  145895-89-2   *Mucins Lignans Selectins.  Cell 1992 Jun 12;69(6):927-38
2,3-bis(3'-hydroxybenzyl)butane-1,4-diol  76543-16-3 1,4-Butanediol, 2,3-bis((3-hydroxyphenyl)methyl)  *Lignans. 
Pharma Action Phytoestrogens 		FEBS Lett 1980;122(1):49
schizandrin B  64121-95-5   *Polycyclic Compounds *Lignans Cyclooctanes Schisandraceae.  Chin Med J (Engl) 3(3):173;1977
schizandrin  7432-28-2 Dibenzo(a,c)cycloocten-6-ol, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, stereoisomer  *Polycyclic Compounds *Lignans *Cyclooctanes Schisandra.  Chem Biol Interact 1982;39(3):301; Chem Pharm Bull (Tokyo) 1979;27(6):1383; Farmatsiia 24(2):35;1975
schizandrol B  58546-54-6 Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-6-ol, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, stereoisomer  *Dioxoles *Lignans *Cyclooctanes Drugs, Chinese Herbal Schisandra. 
Pharma Action Anticarcinogenic Agents 		Biochem Biophys Res Commun 1981;103(4):1131
kadsurenone  95851-37-9   *Benzofurans *Lignans Drugs, Chinese Herbal.  Proc Natl Acad Sci USA 1985;82(3):673
secoisolariciresinol  29388-59-8   *Butylene Glycols *Lignans.  Clin Chim Acta 1989;180(3):293
plicatic acid  16462-65-0 (1S-(1 alpha,2 alpha,3 beta))-1-(3,4-dihydroxy-5-methoxyphenyl)-1,2,3,4-tetrahydro-2,3,7-trihydroxy-3-(hydroxymethyl)-6-methoxy-2-naphthalene carboxylic acid  *Naphthols *Lignans Allergens.  Can Med Assoc J 110(6):656;1974
pinoresinol  487-36-5   *Furans *Lignans.  Science 1997 Jan 17;275(5298):362-6
matairesinol  580-72-3   *Furans *Lignans Plants.  J Biol Chem 1991;266(16):10210
clausenamide  103541-15-7   *Lactams *Lignans Drugs, Chinese Herbal Rutaceae.  Yao Hsueh Hsueh Pao 1987;22(1):33
dihydroguaiaretic acid  36469-60-0 2,3-dimethyl-1-(3'-methoxy-4'-hydroxyphenyl)-4- (3''-methoxy-4''hydroxyphenyl)butane  *Lignans Guaiacol/*analogs & derivatives.  Pharm Res Comm 9(10):917;1977
schizandrin C  61301-33-5   *Polycyclic Compounds *Lignans Cyclooctanes Schisandraceae.  Biochem Pharmacol 1997 Jul 15;54(2):317-9; Yao Hsueh Hsueh Pao 1981;16(4):306
CPH 82  0   *Glycosides *Lignans.  Br J Rheumatol 1989;28(2):124
lariciresinol  83327-19-9   *Furans *Lignans.  Clin Chim Acta 1989;180(3):293
arctigenin  7770-78-7   *Furans *Lignans Plants.  Life Sci 1991;49(25):1871
hydroxymatairesinol  0   *Lignans.  Nutr Cancer. 2000;36(2):207-16
schizandrin A  61281-38-7 Dibenzo(a,c)cyclooctene, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, stereoisomer  *Polycyclic Compounds *Lignans *Cyclooctanes Schisandra.  Chem Biol Interact 1982;39(3):301
syringaresinol  21453-69-0   *Furans *Lignans.  Planta Med 1984;50(3):264
justicidin A  25001-57-4   *Dioxolanes *Lignans.  J Nat Prod 1986;49(2):348; Planta Med 1979;36(3):200
epiyangambin  24192-64-1   *Furans *Lignans Plant Extracts Stereoisomerism.  J Lipid Mediat 1993 May;7(1):1-9
steganacin  41451-68-7   *Lignans 4-Butyrolactone/*analogs & derivatives.  Biochem Biophys Res Commun 85(2):737;1978; Cancer Res 37(9):3071;1977; J Am Chem Soc 95(4):1335;1973; J Am Chem Soc 98(1):267;1976; J Chem Soc (Perkin Trans) 14:1674;1977
cleistanthin  25047-48-7 4-(1,3-benzodioxol-5-yl)-9-((3,4-di-O-methyl-D- xylopyranosyl)oxy)-6,7-dimethoxynaphtho(2,3c)furan- 1(3H)-one  *Glycosides *Lignans Toxins, Biological.  J Chromatogr 107(1):230;1975
nortrachelogenin  34444-37-6 2(3H)-Furanone,dihydro-3-hydroxy-3,4-bis((4-hydroxy-3-methoxyphenyl)methyl)-,(3R-cis)  *Furans *Lignans.  J Nat Prod 42(2):159;1979; J Pharm Sci 68(5):664;1979
eleutheroside E  0   *Glucosides *Lignans.  Arzneimittelforschung. 2001 Jan;51(1):76-83
schizandrer A  82042-38-4 Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxole-5,6-diol, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, 5-benzoate, stereoisomer  *Dioxoles *Lignans *Cyclooctanes Plant Extracts Schisandra.  Chem Biol Interact 1982;39(3):301
eudesmin  526-06-7   *Furans *Lignans.  Phytochemistry 1997 Apr;44(8):1479-82
cubebin  18423-69-3   *Lignans.  J Ethnopharmacol 2001 May;75(2-3):279-8
diphyllin  22055-22-7 9-(13-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxynaphtho(2,3-c)furan-1(3H)-one  *Dioxolanes *Lignans Toxins, Biological.  J Chromatogr 107(1):230;1975
cinnamophilin  154677-96-0   *Lignans Guaiacol/*analogs & derivatives Thromboxane-A Synthase/antagonists & inhibitors.  Br J Pharmacol 1994 Mar;111(3):906-12
hinokiresinol  17676-24-3   *Phenols *Lignans Leukotriene B4/antagonists & inhibitors.  Planta Med 1999 May;65(4):391-2
pinoresinol diglucoside  63902-38-5 beta-D-Glucopyranoside, (tetrahydro-1H,3H-furo(3,4-c)furan-1,4-diyl)bis(2-methoxy-4,1-phenylene) bis-, (1S-(1alpha,3aalpha,4alpha,6aalpha))  *Lignans Eucommiaceae.  J Am Chem Soc 98(17):5412;1976
schisantherin B  58546-55-7   *Dioxoles *Polycyclic Compounds *Lignans Cyclooctanes Schisandraceae.  Sci Sin 1978 Jul-Aug;21(4):483-502
gomisin J  66280-25-9   *Polycyclic Compounds *Lignans Schisandraceae.  Yakugaku Zasshi 1987 Sep;107(9):720-6
magnoshinin  86702-02-5   *Naphthols *Lignans.  Agents Actions Suppl 1991;32:197
syringaresinol-4''-O-glucoside  0   Drugs, Chinese Herbal Plants *Glucosides *Lignans.  Chung Kuo Chung Yao Tsa Chih 1997 Mar;22(3):167-8, 191-2
elenoside  0   *Lignans.  J Nat Prod 2001 Jan;64(1):134-5
taxiresinol  0   *Furans *Plant Extracts *Lignans.  Planta Med. 2004 Jan;70(1):29-33
schisantherin D  64917-82-4   *Lignans *Dioxoles Plant Extracts.  Sci Sin 1978 Jul-Aug;21(4):483-502
anolignan B  158081-98-2 Phenol, 4,4'-(2,3-bis(methylene)-1,4-butanediyl)bis  *Lignans.  J Nat Prod 1994 Jul;57(7):896-904
conidendrin  518-55-8   Pinaceae *Tetrahydronaphthalenes *Lignans.  J Med Chem 2001 Jan 18;44(2):180-5
savinin  0   *Lignans.  Biol Pharm Bull 2001 Feb;24(2):167-71
licarin A  0   *Lignans.  Fitoterapia 2000 Feb;71(1):1-9
agatharesinol  0   *Lignans.  Phytochemistry 2001 Nov;58(6):833-40
saucerneol B  0   *Furans *Lignans.  Chem Pharm Bull (Tokyo) 2001 Sep;49(9):1192-4
hinokinin  26543-89-5   *Dioxoles *Lignans 4-Butyrolactone/*analogs & derivatives.  Phytother Res 2003 May;17(5):449-53
hypophyllanthin  0   *Lignans.  Planta Med 2005 Aug;71(8):721-6
bursehernin  40456-51-7 2(3H)-Furanone, 4-(1,3-benzodioxol-5-ylmethyl)-3-((3,4-dimethoxyphenyl)methyl)dihydro-, (3R-trans)  *Benzyl Compounds *Lactones *Lignans Podophyllin.  Yakugaku Zasshi 1979;99(6):674
prestegane B  93376-04-6   *Lignans 4-Butyrolactone/*analogs & derivatives.  Am J Physiol 1987;253(2 Pt 2):R375
kadsurin  51670-40-7   *Dioxoles *Lignans *Cyclooctanes.  Chem Pharm Bull (Tokyo) 1992 Feb;40(2):406-9
kadsurenin L  149438-61-9 Bicyclo(3.2.1)oct-3-en-2-one, 8-(acetyloxy)-7-(3,4-dimethoxyphenyl)-5-methoxy-6-methyl-3-(2-propenyl)-, (1S-(6-endo,7-exo,8-syn))  *Bicyclo Compounds *Lignans Cyclooctanes.  Yao Hsueh Hsueh Pao 1993;28(3):207-11
galgravin  528-63-2   *Furans *Lignans Drugs, Chinese Herbal.  Chung Kuo Chung Yao Tsa Chih 1993 May;18(5):292-4,318
anolignan A  158081-97-1 1,3-Benzenediol, 4-(3-(1,3-benzodioxol-5-ylmethyl)-2-methylene-3-butenyl)  *Lignans.  J Nat Prod 1994 Jul;57(7):896-904
interiotherin A  0   *Lignans *Cyclooctanes.  J Nat Prod 1996 Nov;59(11):1066-8
rhinacanthin E  0   *Lignans.  J Nat Prod 1997 Jun;60(6):635-7
taiwanin A  0   *Furans *Lignans.  Phytochemistry 2000 Oct;55(3):227-32
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