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Carcinogens
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Definition
: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Manual 24.5.6.2+
See Also
Anticarcinogenic Agents
;
Cocarcinogenesis
;
Mutagens
;
Oncogenic Viruses
Examples
Carcinogens, Environmental
;
Peroxisome Proliferators
Other names
Tumor Promoters; Tumor Initiators; Oncogens; Promoters, Tumor; Initiators, Tumor
Substances having this pharmacologic action:
4-biphenylamine
;
butyl(3-carboxypropyl)nitrosamine
;
nickel subsulfide
;
Trp-P-2
;
4-dichlorobenzene
;
4-methylcatechol
;
2,2-bis(4-glycidyloxyphenyl)propane
;
potassium bromate
;
ferric nitrilotriacetate
;
propylnitrosourea
;
7-methylbenzanthracene
;
teleocidin
;
dihydroteleocidin B
;
dibenzacridine
;
N-nitrosodiphenylamine
;
2-toluidine
;
aniline
;
N-ethyl-N-hydroxyethylnitrosamine
;
Glu-P-2
;
1-phenylazo-2-naphthol
;
ANFT
;
2,6-diaminotoluene
;
N-amyl-N-methylnitrosamine
;
bromodichloromethane
;
ochratoxin A
;
N,N'-dinitrosopiperazine
;
1,2,5,6-dibenzanthracene
;
4-acetylaminostilbene
;
4-acetylaminofluorene
;
1,3-butadiene
;
N-(deoxyguanosin-8-yl)-2-aminofluorene
;
2-amino-3-methylimidazo(4,5-f)quinoline
;
hydrazine
;
methylazoxymethanol
;
2-nitro-7-methoxynaphtho(2-1b)furan
;
betadex
;
sodium nitrate
;
2-cyanoethylene oxide
;
1,8-dinitropyrene
;
4-chloromethylbiphenyl
;
4-hydroxymethylbiphenyl
;
3-nitrofluoranthene
;
6-nitrobenzo(a)pyrene
;
2-amino-3,4-dimethylimidazo(4,5-f)quinoline
;
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
;
1,3-dinitropyrene
;
1,2-dihydroxy-epoxy-1,2,3,4-tetrahydro-5-methylchrysene
;
ethyl acrylate
;
alpha-hexachlorocyclohexane
;
fluorene
;
carbazole
;
dibenzo(a,l)pyrene
;
chlorozotocin
;
5-methylchrysene
;
dipin
;
n-dodecane
;
glycidol
;
2-phenylphenol
;
N'-nitrosonornicotine
;
4-hydroxyphenylacetic acid
;
2',3-dimethyl-4-aminobiphenyl
;
phorbol-12,13-didecanoate
;
pristane
;
propylene oxide
;
methyleugenol
;
pirinixic acid
;
N-hydroxy-2-aminofluorene
;
Microcystins
;
N-phenyl-1-naphthylamine
;
4,4'-diaminodiphenylmethane
;
N-nitrosobutylurea
;
N-nitrosomorpholine
;
N-nitrosopiperidine
;
carbamylhydrazine
;
aristolochic acid I
;
aflatoxin B1-2,3-oxide
;
2-anthramine
;
dehydroretronecine
;
erythritol anhydride
;
benzo(a)pyrene 4,5-epoxide
;
Phorbol Esters
;
Diethylstilbestrol
;
Asbestos
;
Azoxymethane
;
Tetrachloroethylene
;
Tetradecanoylphorbol Acetate
;
Thorium Dioxide
;
Urethane
;
Vinyl Chloride
;
1-Naphthylamine
;
2-Acetylaminofluorene
;
2-Naphthylamine
;
3,3'-Dichlorobenzidine
;
4-Hydroxyaminoquinoline-1-oxide
;
4-Nitroquinoline-1-oxide
;
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
;
9,10-Dimethyl-1,2-benzanthracene
;
Phorbol 12,13-Dibutyrate
;
Okadaic Acid
;
Acrylonitrile
;
1,2-Dimethylhydrazine
;
p-Dimethylaminoazobenzene
;
Dimethylhydrazines
;
Cycasin
;
Butylated Hydroxyanisole
;
Carbadox
;
2,4-diaminotoluene
;
mezerein
;
aflatoxicol
;
2-aminofluorene
;
asarone
;
1,2-diamino-4-nitrobenzene
;
dibutylnitrosamine
;
diisopropanolnitrosamine
;
2-nitrosofluorene
;
4-vinyl-1-cyclohexene dioxide
;
N-nitroso(di-n-propyl)amine
;
7H-dibenzo(c,g)carbazole
;
ENNG
;
nitrosobis(2-oxopropyl)amine
;
N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine
;
styrene oxide
;
chrysarobin
;
bromoform
;
N-nitrosodiethanolamine
;
N-nitroso-2,6-dimethylmorpholine
;
methyl(acetoxymethyl)nitrosamine
;
nitrosobenzylmethylamine
;
acetylhydrazine
;
direct black 3
;
cyclopenta(c,d)pyrene
;
2,4-dinitrotoluene
;
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
;
1-nitronaphthalene
;
vinyl fluoride
;
debromoaplysiatoxin
;
1,2-epoxy-3,4-dihydroxy-1,2,3,4-tetrahydrobenzo(c)phenanthrene
;
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
;
3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone
;
butachlor
;
phenethyl isothiocyanate
;
calyculin A
;
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
;
4-(methylnitrosoamino)-4-(3-pyridyl)-1-butanol
;
methyl tert-butyl ether
;
ptaquiloside
;
indolactam V
;
3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine
Substance
CAS Registry & name
Categories
Source
Drugs
*
N-
(2-
methoxyphenyl)hydroxylamine
0
*Hydroxylamines
Carcinogens.
Mutat Res. 2011 Dec 24;726(2):160-8
2-
hydroxy-
4-
glutathion-
S-
yl-
17 beta-
estradiol
0
Estradiol/*analogs & derivatives
Glutathione/*analogs & derivatives
Carcinogens.
Carcinogenesis 1998 Jan;19(1):133-9
Ag 243-
5 protein, Mycoplasma arginini
0
*Bacterial Proteins
*Neoplasm Proteins
Carcinogens.
Microbiol Immunol 1995;39(6):393-400
limonene
138-86-3
*Terpenes
*Cyclohexenes
Carcinogens
Solvents
Anticarcinogenic Agents.
Digest Dis 21(11):926;1976; Food Cosmet Toxicol 12(5-6):703;1974; J Med Entomol 11(5):617;1974; Life Sci 19:1559;1976; Xenobiot 5(1):33;1975; Xenobiot 6(6):377;1976