Definition: An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Other names Streptozotocin; Streptozocin Teva Brand; Zanosar; Teva Brand of Streptozocin; Streptozotocine; 2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-gl
chlorozotocin [ 2-(3-(2-chloroethyl)-3-nitrodoureido)-2-deoxy-D-glucopyranose,NSC 178,248,NSC-178248,chlorozotocin, (L)-isomer ] 2-chloroethyl analog of streptozotocin with superior activity against leukemia L1210 and reduced bone marrow toxicity; RN given refers to (D)-isomer; structure
Cancer 43(6):2189;1979; Biochem Pharmacol 26:2331;1977; Cancer 40(5) suppl:2640;1977; Cancer Chemother Pharmacol 1(1):15;1978; Cancer Chemother Pharmacol 1979;3(4):217; Cancer Res 1980;40(1):50; Cancer Res 37(3):783;1977; Cancer Res 37(8):2615;1977; Cancer Treat Rep 1979;63(8):1409; Cancer Treat Rep 60(6):699;1976; Cancer Treat Rep 60(6):801;1976; Cancer Treat Rep 62(1):31;1978; Cancer Treat Rep 62(8):1145;1978; Cancer Treat Rep 63(1):17;1979; Clin Pharmacol Ther 23(6):712;1978; Dokl Akad Nauk SSSR 245(1):260;1979; J Clin Invest 1979;64(4):1103; J Med Assoc Ga 66(9):729;1977; J Med Chem 18(1):104;1975; J Med Chem 22(5):597;1979
