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Okadaic Acid

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Definition: A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. (Thromb Res 1992;67(4):345-54 & Cancer Res 1993;53(2):239-41)     
Pharmacological Action Carcinogens; Enzyme Inhibitors; Ionophores 		Other names Acid, Okadaic; Acid, Ocadaic; Ocadaic Acid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
7-deoxyokadaic acid  0   Okadaic Acid/*analogs & derivatives Phosphoprotein Phosphatases/antagonists & inhibitors. J Org Chem 2009 Jan 16;74(2):910-3
belizeanic acid  0   Okadaic Acid/*analogs & derivatives. Chemistry. 2008;14(23):6948-56
7-hydroxymethyl-2-methylene-octa-4,7-dienyl okadaate  0   Okadaic Acid/*analogs & derivatives Marine Toxins. Toxicon 2007 Sep 15;50(4):470-8
19-epi-okadaic acid  0   Okadaic Acid/*analogs & derivatives. Org Lett 2007 Aug 2;9(16):3045-8
DTX5c compound  0   Okadaic Acid/*analogs & derivatives. Toxicon. 2006 Jun 15;47(8):920-4
27-O-acetyldinophysistoxin 1  0   Okadaic Acid/*analogs & derivatives. J Nat Prod 2003 Jun;66(6):838-43
27-O-acetylokadaic acid  0   Okadaic Acid/*analogs & derivatives. J Nat Prod 2003 Jun;66(6):838-43
DTX-6 compound  0   Okadaic Acid/*analogs & derivatives. J Nat Prod 2001 Oct;64(10):1363-4
OA48-18 protein, human  0   *Neoplasm Proteins *Nerve Tissue Proteins *Phosphoproteins Okadaic Acid. J Biomed Sci 2000 Mar-Apr;7(2):152-9
EIF1 protein, human  0   *Neoplasm Proteins *Nerve Tissue Proteins *Eukaryotic Initiation Factors Okadaic Acid. J Biomed Sci 2000 Mar-Apr;7(2):152-9
okadaic acid diol ester  0   Okadaic Acid/*analogs & derivatives Dinoflagellida Marine Toxins. Toxicon 1997 Nov;35(11):1591-603
okadaic acid-sensitive phosphatase  EC 3.1.3.-   *Phosphoprotein Phosphatases Okadaic Acid. Mol Cell Biol 1991;11(2):1171
okadaic acid receptor  0   *Receptors, Drug Okadaic Acid. Adv Second Messenger Phosphoprotein Res 1990;24:340
dinophysistoxin 1  81720-10-7   *Pyrans Dinoflagellida Marine Toxins Okadaic Acid. Toxicon 1986;24(11-12):1141

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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