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Phorbol 12,13-Dibutyrate

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Definition: A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.  D25-26 qualif; DF:PDBU   
Pharmacological Action Carcinogens 		Other names Phorbol 12,13 Dibutyrate; 12,13-Dibutyrate, Phorbol; Phorbol-12,13-Dibutyrate

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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