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aristolochic acid I

under Aristolochic Acids
More information in Books or onNLM PubMed
More on Aristolochic Acids Definition: Nitro-phenanthrenes occurring in ARISTOLOCHIACEAE and other plants. They derive from stephanine (APORPHINES) by oxidative ring cleavage. The nitro group is a reactive alkylator (ALKYLATING AGENTS) that binds to biological macromolecules. Ingestion by humans is associated with nephropathy (NEPHRITIS). There is no relationship to the similar named aristolochene (SESQUITERPENES).     
SubstanceCAS Registry & nameCategoriesSourceDrugs*
aristolochic acid I [ 8-methoxy-6-nitrophenanthro(3,4-d)-1,3-dioxole-5-carboxylic acid,Tardolyt,aristolochic acid,aristolochic acid A,aristolochic acid I, sodium salt ]
  phospholipase A inhibitor; RN given refers to parent cpd; structure 		313-67-7   *Aristolochic Acids
Pharma Action Antiviral Agents; Carcinogens; Mutagens 		Arzneim Forsch 27(12):2297;1977; Experientia 34(9):1192;1978; Il Farm 27(4):257;1972; J Pharm Sci 64(2):345;1975; Osterr Z Onkol 2(6):151;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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