Definition: A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.
Other names Monocrotaline, (all-xi)-Isomer; Monocrotaline Hydrochloride (13alpha,14alpha)-Isom
dehydroretronecine [ 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine,dehydro-retronecine,dehydroheliotridine,dehydroretro-necine,dehydroretronecine, (R)-isomer,dehydroretronecine, (S)-isomer ] major pyrrole metabolite of monocrotaline; RN given refers to cpd without isomeric designation
Cancer Res 35(4):997;1975; Cancer Res 37(9):3141;1977; Chem Biol Interact 13(3-4):243;1976; Chem Biol Interactions 12(1):19;1976; Fd Cosmet Tox 15(5):419;1977; J Nat Cancer Inst 56(4):787;1976; J Natl Cancer Inst 61(1):85;1978; Mol Pharmacol 14(6):1189;1978; Proc Soc Exp Biol Med 144(3):834;1973; Res Comm Chem Pathol Pharmacol 11(1):79;1975
