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Mutagens

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Definition: Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.  consider also MUTATION   
See Also Alkylating Agents; DNA Adducts; Mutagenesis
Examples Aneugens 		Other names Genotoxins; Clastogens
Substances having this pharmacologic action: 3,N(4)-ethenocytosine; Trp-P-1; Trp-P-2; 2-nitrofluorene; ferric nitrilotriacetate; musk ambrette (artificial); propylnitrosourea; 2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole; Glu-P-2; 3,4-epoxy-1-butene; 2,4,6-trichlorophenol; ammonium fluoride; ANFT; 2,6-diaminotoluene; 4-aminophenol; methylene bromide; 4-acetylaminostilbene; 1,3-butadiene; hydroquinone; 2-amino-3-methylimidazo(4,5-f)quinoline; 2-amino-N(6)-hydroxyadenine; 2-nitro-7-methoxynaphtho(2-1b)furan; 6-N-hydroxylaminopurine; 1-nitropyrene; 1-hydroxypyrene; 1,6-dinitropyrene; 1,8-dinitropyrene; 4-chloromethylbiphenyl; 4-hydroxymethylbiphenyl; 1,3-dichloro-2-propanol; 3-nitrofluoranthene; 6-nitrobenzo(a)pyrene; 2-amino-3,4-dimethylimidazo(4,5-f)quinoline; 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; galangin; Kathon 886; 1-(1-glycero)dodeca-1,3,5,7,9-pentaene; 1,3-dinitropyrene; ethyl acrylate; shogaol; 1-nitrobenzo(a)pyrene; fusarin C; 3-nitrobenzo(a)pyrene; dimethyl sulfate; dipin; acridine half-mustard; danthron; 5-formyluracil; fotrin; N,N'-dimethylnitrosourea; chlorophacinone; dioxidine; 1,N(6)-ethenoadenine; harman; methyleugenol; pirinixic acid; sodium bisulfite; N-hydroxy-2-aminofluorene; cholesterol 7-hydroperoxide; 9,10-phenanthrenequinone; benzo(c)phenanthrene; 6-methyl-2-ethyl-3-hydroxypyridine; N-nitrosomorpholine; N-nitrosopiperidine; cholesterol hydroperoxide; desmethylmisonidazole; benzonidazole; 2,5-bis(1-aziridinyl)-3,6-bis(2-methoxyethoxy)-4-benzoquinone; 2-anthramine; erythritol anhydride; mecarzole; trofosfamide; aristolochic acid I; norharman; Thiram; 4-Hydroxyaminoquinoline-1-oxide; 4-Nitroquinoline-1-oxide; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Sodium Azide; 1,2-Dimethylhydrazine; Patulin; Methyl Methanesulfonate; Furylfuramide; Acridine Orange; Cyclophosphamide; Bromouracil; Monocrotophos; Carbadox; Ethyl Methanesulfonate; Aminacrine; 2,4-diaminotoluene; formal glycol; diethyl sulfate; 2-aminofluorene; diisopropanolnitrosamine; ENNG; nitrosobis(2-oxopropyl)amine; styrene oxide; elmustine; cyclopenta(c,d)pyrene; chrysophanic acid; nitrofurylacrylic acid; 2-bromopropane; 8-oxodeoxyguanosine triphosphate; acridine mustard; 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone; calicheamicin gamma(1)I; 2'-deoxyadenosine; cordycepin; 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; ptaquiloside; 3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine; 2,2'-azobis(2-amidinopropane)
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
8,9-dihydroxy-8,9-dihydro-aflatoxin B1  0   Aflatoxin B1/*analogs & derivatives Mutagens. Carcinogenesis. 1980 Jan;1(1):79-90
colibactin  0   *Peptides *Polyketides Mutagens. Int J Med Microbiol. 2007 Feb;297(1):9-15.
2-(2-(acetylamino)-4-(bis(2-hydroxyethyl)amino)-5-methoxyphenyl)-5-amino-7-bromo-4-chloro-2H-benzotriazole  0   *Triazoles Mutagens. Mutat Res 2001 Nov 15;498(1-2):107-15
2-(4-(bis(2-acetoxyethyl)amino)-2-(acetylamino)-5-methoxyphenyl)-5-amino-7-bromo-4-chloro-2H-benzotriazole  0   *Triazoles Mutagens. Mutat Res 2001 Nov 15;498(1-2):107-15
N-hydroxy-aminophenylnorharman  0   *Indoles *Pyridines Mutagens. Mutat Res 2001 Jul 25;494(1-2):63-72
DPX E9636  0   Urea/*analogs & derivatives Mutagens. Environ Mol Mutagen 1998;32(1):39-46
chlorambucil half mustard  0   *Chlorambucil Mutagens. Mutat Res 1998 Jun 5;401(1-2):153-64
lacidipine  103890-78-4 diethyl 2,6-dimethyl-4-(2-((E)-2-((2-methylpropan-2-yl)oxycarbonyl)ethenyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate  *Dihydropyridines Mutagens.
Pharma Action Antihypertensive Agents ; Calcium Channel Blockers 		Clin Pharmacol Ther 1989;46(1):94
preparation No. 012074  75035-36-8   Organic Chemicals Mutagens. Biull Eksp Biol Med 1980;89(7):92

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