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Mutagens
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Definition
: Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
consider also MUTATION
See Also
Alkylating Agents
;
DNA Adducts
;
Mutagenesis
Examples
Aneugens
Other names
Genotoxins; Clastogens
Substances having this pharmacologic action:
3,N(4)-ethenocytosine
;
Trp-P-1
;
Trp-P-2
;
2-nitrofluorene
;
ferric nitrilotriacetate
;
musk ambrette (artificial)
;
propylnitrosourea
;
2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole
;
Glu-P-2
;
3,4-epoxy-1-butene
;
2,4,6-trichlorophenol
;
ammonium fluoride
;
ANFT
;
2,6-diaminotoluene
;
4-aminophenol
;
methylene bromide
;
4-acetylaminostilbene
;
1,3-butadiene
;
hydroquinone
;
2-amino-3-methylimidazo(4,5-f)quinoline
;
2-amino-N(6)-hydroxyadenine
;
2-nitro-7-methoxynaphtho(2-1b)furan
;
6-N-hydroxylaminopurine
;
1-nitropyrene
;
1-hydroxypyrene
;
1,6-dinitropyrene
;
1,8-dinitropyrene
;
4-chloromethylbiphenyl
;
4-hydroxymethylbiphenyl
;
1,3-dichloro-2-propanol
;
3-nitrofluoranthene
;
6-nitrobenzo(a)pyrene
;
2-amino-3,4-dimethylimidazo(4,5-f)quinoline
;
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
;
galangin
;
Kathon 886
;
1-(1-glycero)dodeca-1,3,5,7,9-pentaene
;
1,3-dinitropyrene
;
ethyl acrylate
;
shogaol
;
1-nitrobenzo(a)pyrene
;
fusarin C
;
3-nitrobenzo(a)pyrene
;
dimethyl sulfate
;
dipin
;
acridine half-mustard
;
danthron
;
5-formyluracil
;
fotrin
;
N,N'-dimethylnitrosourea
;
chlorophacinone
;
dioxidine
;
1,N(6)-ethenoadenine
;
harman
;
methyleugenol
;
pirinixic acid
;
sodium bisulfite
;
N-hydroxy-2-aminofluorene
;
cholesterol 7-hydroperoxide
;
9,10-phenanthrenequinone
;
benzo(c)phenanthrene
;
6-methyl-2-ethyl-3-hydroxypyridine
;
N-nitrosomorpholine
;
N-nitrosopiperidine
;
cholesterol hydroperoxide
;
desmethylmisonidazole
;
benzonidazole
;
2,5-bis(1-aziridinyl)-3,6-bis(2-methoxyethoxy)-4-benzoquinone
;
2-anthramine
;
erythritol anhydride
;
mecarzole
;
trofosfamide
;
aristolochic acid I
;
norharman
;
Thiram
;
4-Hydroxyaminoquinoline-1-oxide
;
4-Nitroquinoline-1-oxide
;
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
;
Sodium Azide
;
1,2-Dimethylhydrazine
;
Patulin
;
Methyl Methanesulfonate
;
Furylfuramide
;
Acridine Orange
;
Cyclophosphamide
;
Bromouracil
;
Monocrotophos
;
Carbadox
;
Ethyl Methanesulfonate
;
Aminacrine
;
2,4-diaminotoluene
;
formal glycol
;
diethyl sulfate
;
2-aminofluorene
;
diisopropanolnitrosamine
;
ENNG
;
nitrosobis(2-oxopropyl)amine
;
styrene oxide
;
elmustine
;
cyclopenta(c,d)pyrene
;
chrysophanic acid
;
nitrofurylacrylic acid
;
2-bromopropane
;
8-oxodeoxyguanosine triphosphate
;
acridine mustard
;
3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone
;
calicheamicin gamma(1)I
;
2'-deoxyadenosine
;
cordycepin
;
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
;
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
;
ptaquiloside
;
3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine
;
2,2'-azobis(2-amidinopropane)
Substance
CAS Registry & name
Categories
Source
Drugs
*
8,9-
dihydroxy-
8,9-
dihydro-
aflatoxin B1
0
Aflatoxin B1/*analogs & derivatives
Mutagens.
Carcinogenesis. 1980 Jan;1(1):79-90
colibactin
0
*Peptides
*Polyketides
Mutagens.
Int J Med Microbiol. 2007 Feb;297(1):9-15.
2-
(2-
(acetylamino)-
4-
(bis(2-
hydroxyethyl)amino)-
5-
methoxyphenyl)-
5-
amino-
7-
bromo-
4-
chloro-
2H-
benzotriazole
0
*Triazoles
Mutagens.
Mutat Res 2001 Nov 15;498(1-2):107-15
2-
(4-
(bis(2-
acetoxyethyl)amino)-
2-
(acetylamino)-
5-
methoxyphenyl)-
5-
amino-
7-
bromo-
4-
chloro-
2H-
benzotriazole
0
*Triazoles
Mutagens.
Mutat Res 2001 Nov 15;498(1-2):107-15
N-
hydroxy-
aminophenylnorharman
0
*Indoles
*Pyridines
Mutagens.
Mutat Res 2001 Jul 25;494(1-2):63-72
DPX E9636
0
Urea/*analogs & derivatives
Mutagens.
Environ Mol Mutagen 1998;32(1):39-46
chlorambucil half mustard
0
*Chlorambucil
Mutagens.
Mutat Res 1998 Jun 5;401(1-2):153-64
lacidipine
103890-78-4 diethyl 2,6-
dimethyl-
4-
(2-
((E)-
2-
((2-
methylpropan-
2-
yl)oxycarbonyl)ethenyl)phenyl)-
1,4-
dihydropyridine-
3,5-
dicarboxylate
*Dihydropyridines
Mutagens.
Pharma Action
Antihypertensive Agents
;
Calcium Channel Blockers
Clin Pharmacol Ther 1989;46(1):94
preparation No. 012074
75035-36-8
Organic Chemicals
Mutagens.
Biull Eksp Biol Med 1980;89(7):92