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Protein Kinase Inhibitors
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Definition
: Agents that inhibit PROTEIN KINASES.
Other names
Kinase Inhibitors, Protein; Inhibitors, Protein Kinase
Substances having this pharmacologic action:
N(6),N(6)-dimethyladenine
;
Phosphatidylethanolamine Binding Protein
;
Cyclin-Dependent Kinase Inhibitor Proteins
;
Cyclin-Dependent Kinase Inhibitor p21
;
Cyclin-Dependent Kinase Inhibitor p27
;
Cyclin-Dependent Kinase Inhibitor p57
;
Cyclin-Dependent Kinase Inhibitor p15
;
Cyclin-Dependent Kinase Inhibitor p18
;
Cyclin-Dependent Kinase Inhibitor p19
;
wortmannin
;
Genistein
;
Emodin
;
adenosine-3',5'-cyclic phosphorothioate
;
SU 5416
;
erlotinib
;
vatalanib
;
gefitinib
;
sorafenib
;
dasatinib
;
lapatinib
;
crizotinib
;
imatinib
;
roscovitine
;
flavopiridol
;
1-(5-isoquinolinylsulfonyl)-3-methylpiperazine
;
butyrolactone I
;
KN 93
;
KT 5823
;
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide
;
7-hydroxystaurosporine
;
fasudil
;
N-(2-guanidinoethyl)-5-isoquinolinesulfonamide
;
N-(2-aminoethyl)-5-isoquinolinesulfonamide
Substance
CAS Registry & name
Categories
Source
Drugs
*
N-
(2,6-
diethylphenyl)-
1-
methyl-
8-
((4-
((1-
methylpiperidin-
4-
yl)carbamoyl)-
2-
(trifluoromethoxy)phenyl)amino)-
4,5-
dihydro-
1H-
pyrazolo(4,3-
h)quinazoline-
3-
carboxamide
0
*Pyrazoles
*Quinazolines
Protein Kinase Inhibitors.
Cancer Res 2010 Dec 15;70(24):10255-64
HH-
GV-
678
0
*Aminopyridines
*Benzamides
Protein Kinase Inhibitors.
Leukemia. 2010 Oct;24(10):1807-9
bafetinib
859212-16-1
*Pyrimidines
Protein Kinase Inhibitors.
Blood 2005 Dec 1;106(12):3948-54
CP-
654577
0
*Quinazolines
Protein Kinase Inhibitors.
Cancer Res. 2003 Aug 1;63(15):4450-9
BIRB 796
0
*Naphthalenes
*Pyrazoles
Protein Kinase Inhibitors.
Nat Struct Biol 2002 Apr;9(4):268-72
temsirolimus
0
Sirolimus/*analogs & derivatives
Antineoplastic Agents
Protein Kinase Inhibitors.
Bull Cancer 1999 Oct;86(10):808-11
TORISEL
HA 1100
0
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives
Protein Kinase Inhibitors.
Eur J Pharmacol 1998 Nov 6;360(2-3):257-64
3-
isomangostin
0
*Xanthones
Protein Kinase Inhibitors.
Chem Biol Interact 1998 Jul 3;114(1-2):121-40
9-
phenanthrol
484-17-3
*Phenanthrenes
Protein Kinase Inhibitors.
Biol Chem Hoppe Seyler 1994 Aug;375(8):527-35
4-
methyl-
5-
(4-
pyridinyl)-
2(3H)-
oxazolone
132338-12-6
Oxazolone/*analogs & derivatives
Protein Kinase Inhibitors.
J Cell Physiol 1992 Sep;152(3):448-57
KN 04
129695-80-3
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives
Protein Kinase Inhibitors.
J Pharmacol Exp Ther 1990;254(2):598
NA 0344
120925-59-9 9,12-
Epoxy-
1H-
diindolo(1,2,3-
fg:3',2',1'-
kl)pyrrolo(3,4-
i)(1,6)benzodiazocin-
1-
one, 10-
((dimethylamino)methyl)-
2,3,9,10,11,12-
hexahydro-
10-
hydroxy-
9-
methyl-
, (9S-
(9alpha,10beta,12alpha))
*Carbazoles
Protein Kinase Inhibitors.
Life Sci 1989;44(19):1351
IP 20
99534-03-9
*Peptides
Protein Kinase Inhibitors.
Biochem J 1989 Feb 1;257(3):715-21; Cell Regul 1990 Dec;1(13):1015-25
2-
isobutyl-
3-
oxo-
4-
chloro-
2-
butylcarbonate
81652-49-5 Carbonic acid, 3-
chloro-
1-
methyl-
2-
oxopropyl 2-
methylpropyl ester
*Lactates
Hexokinase/antagonists & inhibitors
Protein Kinase Inhibitors/antagonists & inhibitors.
Biochemistry 1982;21(12):2984
indirubin
479-41-4
Indoles
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein Kinase Inhibitors.
Pharma Action
Antibiotics, Antineoplastic
;
Coloring Agents
Chung Kuo I Hsueh Ko Huseh Yuan Hsueh Pao 1980;2(2):83
mangostin
6147-11-1 1,3,6-
trihydroxy-
7-
methoxy-
2,8-
bis(3-
methyl-
2-
butenyl)-
9H-
xanthen-
9-
one
*Xanthones
Protein Kinase Inhibitors.
Arch Int Pharmacodyn Ther 239(2):257;1979