Leukemia (definition)

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ψ ψ	Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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Definition: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.

Examples Blast Crisis; Leukemia, Myeloid, Accelerated Phase; Leukemia, Myeloid, Chronic-Phase

Other names Chronic Myeloid Leukemias; Chronic Myeloid Leukemia; Chronic Myelogenous Leukemias; Chronic Myelogenous Leukemia; Chronic Myelocytic Leukemias; Chronic Myelocytic Leukemia; Chronic Granulocytic Leukemias; Chronic Granulocytic Leukemia; Myeloid Leukemia, Philadelphia-Positive; Myeloid Leukemia, Ph1-Positive; Myelogenous Leukemia, Ph1-Positive; Leukemia, Myeloid, Philadelphia-Positive; Leukemia, Myeloid, Philadelphia Positive; Leukemia, Myeloid, Ph1-Positive; Leukemia, Myeloid, Ph1 Positive; Leukemia, Myelogenous, Ph1-Positive; Leukemia, Myelogenous, Ph1 Positive; Myeloid Leukemia, Chronic; Myelogenous Leukemia, Chronic; Myelocytic Leukemia, Chronic

Substance	CAS Registry & name	Categories	Source
DCC-2036	0	*Quinolines Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy.	Cancer Res. 2011 May 1;71(9):3189-95
dasatinib	302962-49-8	Pyrimidines Thiazoles Fluorine Radioisotopes Protein-Tyrosine Kinases/antagonists & inhibitors Leukemia, Myelogenous, Chronic, BCR-ABL Positive. Pharma Action Protein Kinase Inhibitors	Science 2004 Jul 16;305(5682):399-401	SPRYCEL
indirubin	479-41-4	Indoles Leukemia, Myelogenous, Chronic, BCR-ABL Positive Protein Kinase Inhibitors. Pharma Action Antibiotics, Antineoplastic ; Coloring Agents	Chung Kuo I Hsueh Ko Huseh Yuan Hsueh Pao 1980;2(2):83
homoharringtonine	26833-87-4	Harringtonines Leukemia, Myelogenous, Chronic, BCR-ABL Positive Apoptosis. Pharma Action* Antineoplastic Agents, Phytogenic ; Angiogenesis Inhibitors	Chin Med J (Eng)92(3):175;1979; J Pharm Sci 61(8):1227;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive