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7-hydroxystaurosporine
under Staurosporine
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Staurosporine
Definition
: An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)
Substance
CAS Registry & name
Categories
Source
Drugs
*
7-hydroxystaurosporine [ 7-hydroxy-staurosporine,UCN 01,UCN 02,UCN-01,UCN-02 ]
structure given in first source
112953-11-4 8,12-
Epoxy-
1H,8H-
2,7b,12a-
triazadibenzo(a,g)cyclonona(cde)triinden-
1-
one, 2,3,9,10,11,12-
hexahydro-
3-
hydroxy-
9-
methoxy-
8-
methyl-
10-
(methylamino)
Staurosporine/*analogs & derivatives
Protein Kinase C/antagonists & inhibitors
Pharma Action
Antineoplastic Agents
;
Protein Kinase Inhibitors
J Antibiot (Tokyo) 1987;40(12):1782