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Phthalimides

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Definition: The imide of phthalic acids.     
Examples Thalidomide
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N,N'-dithiobisphthalimide  7764-30-9   *Phthalimides. Syst Biol Reprod Med. 2011 Dec;57(6); 309-17
N-(3-((2-benzo(1,3)dioxol-5-ylethyl)(3-(1-methyl-3-oxo-1,3-dihydroisoindol-2-yl)propionyl)amino)-1-benzyl-2-(hydroxylpropyl))-4-benzyloxy-3,5-dimethoxybenzamide  0   *Benzamides *Phthalimides. J Mol Biol. 2003 Mar 14;327(1):173-81.
N-((E)-hex-2-enyl)phthalimide  0   *Phthalimides. Bioorg Med Chem. 2011 May 1;19(9):2850-8
W84 compound  0   *Quaternary Ammonium Compounds *Phthalimides Cholinergic Agents. J Comput Aided Mol Des 2011 Feb;25(2):145-61
5-(3-(2-(guanidino)ethylcarbamoyl)benzylaminocarboyl)-9-hydroxy-1,3-dihydropyrrolo(3,4-c)carbazole-1,3(2H,6H)-dione  0   *Carbazoles *Phthalimides. Bioorg Med Chem 2010 Nov 15;18(22):7878-89
1-(2-benzyl-1,3-dioxoisoindolin-5-yl)-3-(1-phenylethyl)thiourea  0   *Phthalimides Thiourea/*analogs & derivatives. Photochem Photobiol Sci 2010 Oct 28;9(10):1385-90
ampkinone  0   *Benzopyrans *Phthalimides AMP-Activated Protein Kinases/antagonists & inhibitors. J Med Chem 2010 Oct 28;53(20):7405-13
4-chloro-2-(2-(4-(hydroxymethyl)phenyl)-1,3-dioxoisoindoline-5-carboxamido)benzoic acid  0   *Anthranilic Acids *Phthalimides Dynamin I/antagonists & inhibitors. J Med Chem 2010 Jul 22;53(14):5267-80
7,8-dimethoxy-5-methylbenzo(e)isoindole-1,3-dione  0   *Phthalimides. J Med Chem 2010 Feb 11;53(3):994-1003
3-(phthalimidyl)-N-(2-hydroxyphenyl)benzamide  0   *Benzamides *Phthalimides. Bioorg Med Chem Lett 2009 Dec 1;19(23):6502-6
5-(4-(2-phthalimidiylpropanoylamino)benzoylamino)isophthalic acid  0   *Benzamides *Phthalimides. Amino Acids 2009 Oct;37(4):665-72
4,5-bis(4-methoxyanilino)phthalimide  0   *Aniline Compounds *Phthalimides. Nat Chem Biol 2009 Dec;5(12):936-46
2-(3-(4-(2-isopropoxyphenyl)piperazin-1-yl)propyl)-3a,4,7,7a-tetrahydroisoindole-1,3-dione  0   *Phthalimides *Piperazines Receptors, Adrenergic, alpha-1/antagonists & inhibitors. Eur J Pharmacol 2009 Apr 1;607(1-3):213-9
N-3-phthalimidopropyl progargyl ether  0   *Ethers *Phthalimides. Nucleic Acids Symp Ser (Oxf) 2008;(52):385-6
disperse blue SBL  0   *Anthraquinones *Phthalimides. J Environ Sci (China) 2008;20(10):1268-72
N-(1-adamantyl)phthalimide  0   *Phthalimides Adamantane/*analogs & derivatives. Org Lett. 2008 Sep 18;10(18):3965-8
4-aminophthalimide  0   *Phthalimides. Photochem Photobiol Sci 2008 Mar;7(3):361-70
benzophenone-N-methylphthalimide  0   *Benzophenones *Phthalimides. J Phys Chem A. 2008 Feb 21;112(7):1403-7
5-chloro-N-2'-n-pentylphenyl-1,3-dithiophthalimide  0   *Phthalimides. Chem Pharm Bull (Tokyo) 2007 Dec;55(12):1750-4
phthalimide-N-oxyl  0   *Phthalimides. J Org Chem. 2007 Nov 9;72(23):8748-54
CEP 8983  0   *Carbazoles *Phthalimides. Mol Cancer Ther 2007 Aug;6(8):2290-302
N-(o-hydroxyphenyl)phthalimide  0   *Phthalimides. J Org Chem. 2007 Mar 30;72(7):2392-401
2-(4-methylphenyll)-2,3-dihydro-N-(2-hydroxy-3-(4-(2-(1-methylethoxy)phenyl)-1-piperazinyl)propyl)-1,3-dioxo-1H-isoindole-5-carboxamide  0   *Phthalimides *Piperazines Receptors, Adrenergic, alpha-1/antagonists & inhibitors. Eur J Drug Metab Pharmacokinet 2006 Oct-Dec;31(4):271-6
2-(3-fluorophenyl)-2,3-dihydro-N-(2-hydroxy-3-(4-(2-(1-methylethoxy)phenyl)-1-piperazinyl)propyl)-1,3-dioxo-1H-isoindole-5-carboxamide  0   *Phthalimides *Piperazines Receptors, Adrenergic, alpha-1/antagonists & inhibitors. Eur J Drug Metab Pharmacokinet 2006 Oct-Dec;31(4):271-6
poly(ureidophthalimide)  0   *Polymers *Phthalimides. Chemistry. 2006 Aug 7;12(23):6129-37
LASSBIO596  0   *Phthalimides. Braz J Med Biol Res. 2006 Feb;39(2):283-7
cis-5-hydroxy-3-phthalimidoglutarimide  0   *Phthalimides *Piperidones. J Org Chem. 2005 Nov 25;70(24):10117-120
poly(2,2'-disulfonylbenzidine terephthalamide)  0   *Phthalimides *Polymers. Langmuir. 2004 Jul 20;20(15):6518-20
N-(tert-butyldimethylsilyl)(15N)phthalimide  0   *Phthalimides. Nucleosides Nucleotides Nucleic Acids. 2006;25(1):29-35
NSC 401077  0   *Indoles *Phthalimides. J Med Chem 2006 Jan 26;49(2):678-83
RWJ-69442  0   *Phthalimides *Piperazines. Eur J Drug Metab Pharmacokinet 2005 Jan-Jun;30(1-2):113-20
3-hydroxy-6-(2-(dimethylamino)ethyl)naphtho(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H,14H)-dione  0   *Carbazoles *Phthalimides. J Med Chem 2005 Mar 10;48(5):1401-13
N-(trichlromethylthio)phthalimide  0   *Phthalimides. J Appl Microbiol 2004;97(6):1132-9
Phenylhomophthalimide  0   *Phthalimides. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4141-5
4-(N,N-dimethylamino) phthalimide  0   *Phthalimides. Org Biomol Chem. 2004 Jul 21;2(14):1965-6
N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide  0   *Benzamides *Phthalimides Receptors, Metabotropic Glutamate/antagonists & inhibitors. Ann N Y Acad Sci 2003 Nov;1003:481-4
phthalimidomethylampicillin  0   *Phthalimides Ampicillin/*analogs & derivatives. Pharm Res 2003 Apr;20(4):624-31
2-(2-(4'-fluorobiphenyl)ethylthio)-5-(phthalimidomethyl)cyclopentanecarboxylic acid  0   *Cyclopentanes *Phthalimides. J Med Chem 2003 Aug 28;46(18):3840-52
2-(4-(4-(5-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl)butyl)-phthalimide  0   *Phthalimides *Pyridines. Bioorg Med Chem Lett. 2003 Feb 10;13(3)
5-ethyl-1-phenyl-5-(3,4,5,6-tetrafluorophthalimido)barbituric acid  0   *Barbiturates *Phthalimides. Eur J Pharmacol. 2002 Oct 25;453(2-3):325-34
N-(4-chloro-2-fluoro-5-propargyloxy)phenyl-2,4,5,6-tetrahydrophthalimide  0   *Phthalimides. Biosci Biotechnol Biochem 2002 Sep;66(9):1799-805
N-(4-amino-2-chlorophenyl)phthalimide  0   *Phthalimides. J Med Chem 2000 Apr 6;43(7):1311-9
N-aminophthalimide  0   *Phthalimides. Org Lett 2002 May 30;4(11):1839-42
N-(pyridin-3-ylmethyl)-4,5,6,7-tetrafluorophthalimide  0   *Phthalimides *Pyridines. Eur J Med Chem 2001 Jul-Aug;36(7-8):639-49
2-(2-aminoethyl)-3-(p-chlorophenyl)-3-hydroxyphthalimidine  0   *Phthalimides. Analyst 2001 Nov;126(11):1963-8
methyl 4,6-O-benzylidene-3-deoxy-3-phthalimido-altropyranoside  0   *Deoxy Sugars *Phthalimides. Carbohydr Res 2001 Apr 23;331(4):461-7
N-phthalimidomethyl-ketomethylene  0   *Phthalimides. J Pharm Pharmacol 2001 Mar;53(3):333-43
JTE-711  0   *Phthalimides. Int Arch Allergy Immunol 2001 Jan-Mar;124(1-3):172-5
4-phthalimido-1,3,4,5-tetrahydro-8-(2,6-dichlorobenzyloxy)-3-oxo-2H-2-benzazepin-2-acetic acid  0   *Benzazepines *Phthalimides. J Org Chem 2000 Oct 6;65(20):6487-92
5,15-bis(N-(Kemp's triacid imido)-2-tolyl)-2,8,12,18-tetraethyl-3,7,13,17-tetramethylporphyrin  0   *Phthalimides *Porphyrins. J Org Chem 2000 Aug 25;65(17):5298-305
N-(4-phenylbutyl)-4,5,6,7-tetrachlorophthalimide  0   *Phthalimides alpha-Glucosidases. Bioorg Med Chem Lett 2000 May 15;10(10):1081-4
N-phenyl-4,5,6,7-tetrachlorophthalimide  0   *Phthalimides alpha-Glucosidases/antagonists & inhibitors. Bioorg Med Chem Lett 2000 May 15;10(10):1081-4
N-(2-(2-(1,3-dioxan-2-yl)phenoxy)-ethyl)phthalimide  0   *Dioxanes *Phthalimides. Acta Crystallogr C 2000 Jun;56 ( Pt 6):705-7
2-methoxy-4-(2-phthalimidinyl)phenylsulfonyl chloride  0   *Phthalimides *Sulfinic Acids. Anal Biochem 2000 Apr 10;280(1):36-41
2-(N-phthalimidomethyl)benzoic acid  0   *Benzoates *Phthalimides. Acta Crystallogr C 2000 Feb;56( Pt 2):246-9
tetrabutylbis(N-phthaloylglycinato)distannoxane dimer  0   *Organotin Compounds *Phthalimides. Acta Crystallogr C 2000 Feb;56( Pt 2):159-60
N-((2,2,5,5-tetramethyl-3-pyrroline-3-carboxamido)propyl)phthalimide  0   *Phthalimides. J Pharmacol Exp Ther 2000 Mar;292(3):838-45
1-(2-methoxyphenyl)-4-(4--(2-phthalimido)cyclohexyl)piperazine  0   *Phthalimides *Piperazines Receptors, Serotonin/antagonists & inhibitors. J Med Chem 1999 Dec 2;42(24):4952-60
phthalascidin  0   *Dioxoles *Phthalimides. Proc Natl Acad Sci U S A 1999 Mar 30;96(7):3496-501
CEP 1612  0   *Dipeptides *Phthalimides. Cell Death Differ 1998 Dec;5(12):1062-75
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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