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Fibrinolysin

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Definition: A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.     
Pharmacological Action Fibrinolytic Agents 		Other names Plasmin; Glu Plasmin; Thrombolysin; Protease F; Glu-Plasmin; Fibrogammin; Aventis Pharma Brand of Plasmin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
lysyl-methionyl(sulfone)-tyrosyl-arginine  0   *Oligopeptides Fibrinolysin/antagonists & inhibitors. Biochemistry. 2011 Oct 4;50(39):8454-62.
gussurobin  EC 3.4.21.7   *Crotalid Venoms *Fibrinolysin. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 2002 Jan;34(1):6-10
textilinin  0   *Elapid Venoms Fibrinolysin/antagonists & inhibitors. Blood Coagul Fibrinolysis 2000 Jun;11(4) 385-93
bdellastasin  0   *Insect Proteins Fibrinolysin/antagonists & inhibitors Serine Proteinase Inhibitors. J Mol Biol 1999 Oct 15;293(1):93-106
cassigarol A  106387-02-4 5H-Dibenzo(a,d)cycloheptene-2,3,6,8-tetrol, 11-(3,4-dihydroxyphenyl)-5-((3,5-dihydroxyphenyl)methyl)-10,11-dihydro  *Phenols Fibrinolysin/antagonists & inhibitors H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Biochem Pharmacol 1992 Jul 7;44(1):33-7
plasmin receptor  0   *Receptors, Peptide Fibrinolysin. Biochem Biophys Res Commun 1990;170(2):748
microplasmin  0   *Fibrinolysin *Peptide Fragments. Proc Natl Acad Sci USA 1987;84(24):8793
alanyl-phenylalanyl-lysine fluoromethane  107573-17-1   *Oligopeptides Fibrinolysin/antagonists & inhibitors. Biochem J 1987;241(3):871
plasmin heavy chain-urokinase conjugate  0   *Fibrinolysin *Urokinase-Type Plasminogen Activator. Thromb Haemost 1986;56(3):364
streptokinase-B-chain plasmin complex  0   *Fibrinolysin *Streptokinase Drug Combinations. Thromb Haemost 1986;56(1):71
BRL 26920  82905-02-0   *Fibrinolysin. Thromb Haemost 1984;51(2):248
plasminase B  EC 3.4.21.-   *Serine Endopeptidases Fibrinolysin/antagonists & inhibitors. Biochem Biophys Res Commun 1984;119(2):758
plasminase A  EC 3.4.21.-   *Serine Endopeptidases Fibrinolysin/antagonists & inhibitors. Biochem Biophys Res Commun 1984;119(2):758
plasmin-plasmin inhibitor complex  0   *alpha-2-Antiplasmin *Fibrinolysin Antifibrinolytic Agents. Blood 1983;61(5):842
technetium Tc 99m plasmin  0   *Fibrinolysin *Organotechnetium Compounds.
Pharma Action Radiopharmaceuticals 		Acta Med Scand 1982;211(1-2):59
lys-plasmin  0   *Fibrinolysin *Peptide Fragments. Biochem J 1981;199(1):121
4-(beta-amidinoethenyl)phenyl-4-guanidinobenzoate dimethanesulfonate  80251-33-8 Benzoic acid, 4-((aminoiminomethyl)amino)-, 4-(3-amino-3-imino-1-propenyl)phenyl ester, dimethanesulfonate  *Guanidines Fibrinolysin/antagonists & inhibitors Kallikreins/antagonists & inhibitors. Biochim Biophys Acta 1981;661(2):342
4-amidino-2-benzoylphenyl 4-guanidinobenzoate dimethanesulfonate  80251-34-9 Benzoic acid, 4-((aminoiminomethyl)amino)-, 4-(aminoiminomethyl)-2-benzoylphenyl ester, dimethanesulfonate  *Guanidines Fibrinolysin/antagonists & inhibitors Kallikreins/antagonists & inhibitors. Biochim Biophys Acta 1981;661(2):342
nafamostat  81525-10-2 Benzoic acid, 4-((aminoiminomethyl)amino)-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dihydrochloride  *Guanidines Fibrinolysin/antagonists & inhibitors Kallikreins/antagonists & inhibitors.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Anticoagulants ; Protease Inhibitors ; Trypsin Inhibitors ; Serine Proteinase Inhibitors ; Complement Inactivating Agents 		Biochim Biophys Acta 1981;661(2):342
CY 218  0   *Fibrinolysin. Rev Med Brux 1981;2(3):167
plasmin-alpha(2)-macroglobulin complex  0   *alpha-Macroglobulins *Fibrinolysin. Tokushima J Exp Med 1979;26(3-4):81
carbamyl plasmin A  EC 3.4.21.-   *Fibrinolysin. Biochim Biophys Acta 570(2):324;1979
deoxyribonuclease, plasmin drug combination  0 Nuclease, deoxyribo-, mixt. with plasmin  *Deoxyribonucleases *Fibrinolysin Drug Combinations. Aust NZ J Obstet Gynaecol 19(1):56;1979
miniplasmin  0   *Fibrinolysin *Peptide Fragments. Biochim Biophys Acta 567(2):472;1979
N,N-dimethylamino-4-(4'-guanidinobenzoyloxy)benzylcarbonyloxyglycolate  0   *Glycolates Fibrinolysin. Biochim Biophys Acta 525(1):194;1978
uroplasmin  64814-93-3 plasmin, urinary  *Fibrinolysin. Urol Nefrol 4:23;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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