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Protease Inhibitors
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Definition
: Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).
PROTEASE INHIBITORY PROTEINS, SECRETORY is also available; DF: PROTEASE INHIB
See Also
Proteinase Inhibitory Proteins, Secretory
Examples
Angiotensin-Converting Enzyme Inhibitors
;
Cysteine Proteinase Inhibitors
;
Dipeptidyl-Peptidase IV Inhibitors
;
HIV Protease Inhibitors
;
Serine Proteinase Inhibitors
Other names
Protease Antagonists; Peptide Peptidohydrolase Inhibitors; Peptide Hydrolase Inhibitors; Peptidase Inhibitors; Endopeptidase Inhibitors; Peptidohydrolase Inhibitors, Peptide; Inhibitors, Protease; Inhibitors, Peptide Peptidohydrolase; Inhibitors, Peptide Hydrolase; Inhibitors, Peptidase; Inhibitors, Endopeptidase; Inhibitor, Protease; Hydrolase Inhibitors, Peptide; Antagonists, Protease; Protease Inhibitor; Antiproteases
Substances having this pharmacologic action:
globomycin
;
alpha 1-inhibitor 3
;
proteinase inhibitor I (plants)
;
1,10-phenanthroline
;
2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate
;
renin inhibitory peptide
;
2-mercaptomethyl-3-guanidinoethylthiopropionic acid
;
4-hydroxymercuribenzoate
;
pepstatin
;
nafamostat
;
FOY 305
;
1,6-bis(cyclohexyloximinocarbonyl)hexane
;
ovomacroglobulin
;
NCO 650
;
1,2-epoxy-3-(p-nitrophenoxy)propane
;
phosphoramidon
;
Proteinase Inhibitory Proteins, Secretory
;
Elafin
;
omapatrilat
;
4-toluenesulfonyl fluoride
;
N-acetyltryptophan
;
Phenylmethylsulfonyl Fluoride
;
Antipain
;
Leupeptins
;
Thiorphan
;
Cilastatin
;
Pepstatins
;
Isoflurophate
;
bestatin
;
4-aminomethylbenzoic acid
;
alpha-1-microglobulin
;
amastatin
;
sampatrilat
;
TIMP1 protein, human
;
TIMP2 protein, human
;
Timp1 protein, mouse
;
benzyloxycarbonyl-Asp-CH2OC(O)-2,6-dichlorobenzene
;
BB 1101
;
tissue inhibitor of metalloproteinase-4
;
GM 6001
;
pigment epithelium-derived factor
;
batimastat
;
TIMP3 protein, human
;
carbobenzoxy-leucyl-leucyl-norvalinal
;
Sch 39370
;
candoxatrilat
;
ecabet
;
SCH 32615
;
epicatechin gallate
;
candoxatril
;
remikiren
;
3-amino-2-hydroxy-4-phenylbutanoic acid
;
antistasin
;
4-des-dimethylaminotetracycline
;
Sch 34826
;
enalkiren
;
sepimostate mesilate
;
acetorphan
;
ditekiren
;
murinoglobulin
Substance
CAS Registry & name
Categories
Source
Drugs
*
NSC48300
0
*Arsenicals
Protease Inhibitors.
Cancer Res. 2012 Feb 1;72(3):736-46
3,5-
bis((4-
nitrophenyl)methylidene)-
1-
prop-
2-
enoylpiperidin-
4-
one
0
*Piperidones
Protease Inhibitors.
Nat Med. 2011 Dec;17(12):636-40
AG1801
0
*Tyrphostins
Protease Inhibitors.
Cell Signal. 2011 Dec;23(12):2076-85
AGL2019
0
*Tyrphostins
Protease Inhibitors.
Cell Signal. 2011 Dec;23(12):2076-85
kexstatin I, Streptomyces platensis
0
*Bacterial Proteins
Protease Inhibitors.
Biochem J 2001 Apr 15;355(Pt 2):339-46
SL 327
0
Aminoacetonitrile/*analogs & derivatives
Protease Inhibitors.
Blood 2001 Apr 1;97(7):2105-14
1-
aminocyclopropaneboronic acid
0
*Boronic Acids
*Cyclopropanes
Protease Inhibitors.
Org Lett 2000 Oct 5;2(20):3095-7
PGE 1132881
0
*Hydroxamic Acids
Protease Inhibitors
Matrix Metalloproteinases/antagonists & inhibitors.
J Pharm Biomed Anal 1999 Mar;19(3-4):343-9
PGE 4410186
0
*Hydroxamic Acids
Protease Inhibitors.
J Pharm Biomed Anal 1999 Mar;19(3-4):343-9
PGE 9818266
0
*Hydroxamic Acids
Protease Inhibitors.
J Pharm Biomed Anal 1999 Mar;19(3-4):343-9
BB 1268
0
Organic Chemicals
Metalloendopeptidases/antagonists & inhibitors
Protease Inhibitors.
Ann Neurol 1998 Jul;44(1):35-46
bdellin
62494-89-7
*Organic Chemicals
Protease Inhibitors.
Res Commun Mol Pathol Pharmacol 1997 Jun;96(3):341-52
CGS 24426A
0
*Succinates
Metalloendopeptidases/antagonists & inhibitors
Protease Inhibitors.
Inflamm Res 1995 Aug;44 Suppl 2:S141-2
CGS 27023A
0
*Hydroxamic Acids
*Pyrazines
Sulfonamides
Metalloendopeptidases/antagonists & inhibitors
Protease Inhibitors.
Inflamm Res 1995 Aug;44 Suppl 2:S117-8
UK 77568
0
Organic Chemicals
Protease Inhibitors
Neprilysin/antagonists & inhibitors.
Clin Exp Pharmacol Physiol 1994 Apr;21(4):307-9
Cst6 protein, rat
0
*Cystatin M
Protease Inhibitors.
Gene 1992 May 15;114(2):257-60
gamma-
anticollagenase
0
Blood Proteins
Protease Inhibitors.
Folia Histochem Cytobiol 1986;24(2):125
epigallocatechin gallate
989-51-5
Catechin/*analogs & derivatives
Protease Inhibitors
Radiation-Protective Agents
Urokinase-Type Plasminogen Activator/antagonists & inhibitors.
Pharma Action
Antioxidants
;
Antimutagenic Agents
;
Anticarcinogenic Agents
;
Neuroprotective Agents
Mutat Res 1985;150(1-2):127
antiprotease C-
II
0
*Plant Proteins
Protease Inhibitors.
Biochim Biophys Acta 1981;662(1):1
CSTA protein, human
80209-89-8 Sericystatin
*Cystatin A
Protease Inhibitors.
Biochem Biophys Res Commun 1980;95(2):801
whey acidic proteins
0
*Milk Proteins
Protease Inhibitors.
Nucleic Acids Res 1982;10(8):2677
beta (1)-
anticollagenase
0
*Blood Proteins
Protease Inhibitors.
Arthritis Rheumat 20(6):1231;1977
trielin
57274-66-5
Propane/*analogs & derivatives
Protease Inhibitors.
Klin Khir 1:12;1979; Klin Khir 12:1;1977; Patol Fiziol Eksp Ter 6:58;1976; Ukr Biokhim Zh 47(2):165;1975; Vestn Khir 120(1):13;1978
carboxypolymethylene
9007-20-9
*Polyvinyls
Drug Carriers
Protease Inhibitors.
J Pharm Pharmacol 25(8):640;1973