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Tissue Plasminogen Activator

More information in Books or onNLM PubMed
Definition: A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.     
Pharmacological Action Fibrinolytic Agents 		Other names Tissue-Type Plasminogen Activator; T-Plasminogen Activator; Plasminogen Activator, Tissue-Type; Alteplase; Tissue Type Plasminogen Activator; Tissue Activator D 44; T Plasminogen Activator; Plasminogen Activator, Tissue Type; Plasminogen Activator, Tissue; Lysatec rtPA; Lysatec rt PA; Hoffmann La Roche Brand of Alteplase; Alteplase Promeco Brand; Alteplase Genentech Brand; Tissue Activator D-44; Tisokinase; Promeco Brand of Alteplase; Lysatec rt-PA; Hoffmann-La Roche Brand of Alteplase; Genentech Brand of AlteplaseDrugs* : ACTIVASE; CATHFLO ACTIVASE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
arginyl-asparagyl-prolyl-aspartyl-glycyl-aspartyl-alanyl-lysyl-prolyl-tryptophan  0   *Peptide Fragments *Tissue Plasminogen Activator. Biochem Biophys Res Commun 2010 Jun 11;396(4):1012-7
amediplase  151912-11-7   *Tissue Plasminogen Activator *Urokinase-Type Plasminogen Activator. BioDrugs 2002;16(5):378-9
lekteplase  EC 3.4.21.68   *Tissue Plasminogen Activator. Arzneimittelforschung 2002;52(1):60-6
tenecteplase  0   *Tissue Plasminogen Activator.
Pharma Action Fibrinolytic Agents 		Lancet 1999 Aug 28;354(9180):716-22TNKASE
tPA stop  0 2,7-bis-(4-amidino-benzylidene)-cycloheptan-1-one dihydrochloride  *Cycloheptanes Tissue Plasminogen Activator/antagonists & inhibitors Serine Proteinase Inhibitors. J Cereb Blood Flow Metab. 2004 Oct;24(10):1153-9; Neuron 1998 Oct;21(4):813-25
TNK-tissue plasminogen activator  EC 3.4.21.-   *Tissue Plasminogen Activator. Circulation 1997 Jan 21;95(2):351-6
N-stearoyl-seryl-proline ethyl ester  131476-72-7   *Dipeptides *Stearates Tissue Plasminogen Activator. Chem Pharm Bull (Tokyo) 1994 Sep;42(9):1854-8
D-K2P  0   *Tissue Plasminogen Activator Recombinant Proteins. Biotechnol Prog 1994 Sep-Oct;10(5):472-9
reteplase  133652-38-7 173-527-Plasminogen activator (human tissue-type), 173-L-serine-174-L-tyrosine-175-L-glutamine  *Tissue Plasminogen Activator Recombinant Proteins.
Pharma Action Fibrinolytic Agents 		Am J Cardiol 1994 Jul 1;74(1):1-4RETAVASE
YM 866  0   *Tissue Plasminogen Activator Recombinant Proteins. Jpn J Pharmacol 1993 Sep;63(1):9-16
T103N, KHRR 296-299 AAAA  0   *Tissue Plasminogen Activator. Thromb Haemost 1993 Aug 2;70(2):307-12
T103N  0   *Tissue Plasminogen Activator. Thromb Haemost 1993 Aug 2;70(2):307-12
SUN 9216  153484-31-2   *Tissue Plasminogen Activator. Stroke 1993 July;24(7):1077-81
FK2P tissue plasminogen activator  0   *Tissue Plasminogen Activator Recombinant Fusion Proteins. Cytotechnology 1992;10(2):157-67
BM 06.021  144906-27-4 Plasminogen activator (human tissue-type reduced)  *Tissue Plasminogen Activator Recombinant Proteins. Naunyn Schmiedebergs Arch Pharmacol 1992 Jul;346(1):108-13
E 6010  122007-85-6   *Epidermal Growth Factor Tissue Plasminogen Activator. Jpn J Pharmacol 1992 Mar;58(3):309-19
technetium Tc 99m-tissue-type plasminogen activator  0   *Tissue Plasminogen Activator *Organotechnetium Compounds. Ann Nucl Med 1991 Jul;5(2):59-64
BM 06.022  0   *Tissue Plasminogen Activator Recombinant Proteins. Z Kardiol 1990;79(Suppl 3):167
duteplase  120608-46-0 Plasminogen activator (human tissue-type 2-chain form protein moiety), 245-L-methionine  *Tissue Plasminogen Activator Recombinant Proteins. DICP 1990;24(12):1236
PLAT protein, human  EC 3.4.21.68   *Tissue Plasminogen Activator. FEBS Lett 1991;278(1):95
delta(2-89)-tissue plasminogen activator  105913-11-9   *Tissue Plasminogen Activator. Thromb Haemost 1990;63(3):464
LY 210825  131462-98-1   *Tissue Plasminogen Activator. Circulation 1990;82(3):930
tissue plasminogen activator-(staphylococcal A, B fragment) dimer  0   *Peptide Fragments *Tissue Plasminogen Activator *Staphylococcal Protein A. Ann Neurol 1989;25(3):281

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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