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Aprotinin

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Definition: A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)     
Pharmacological Action Hemostatics; Serine Proteinase Inhibitors; Trypsin Inhibitors 		Other names Trypsin Inhibitor, Kunitz, Pancreatic; Trypsin Inhibitor, Basic, Pancreatic; Kunitz Pancreatic Trypsin Inhibitor; Kallikrein-Trypsin Inactivator; Bovine Kunitz Pancreatic Trypsin Inhibitor; Basic Pancreatic Trypsin Inhibitor; BPTI, Basic Pancreatic Trypsin Inhibitor; Kallikrein Trypsin Inactivator; Inactivator, Kallikrein-Trypsin; Zymofren; Trasylol; Traskolan; Sanofi Winthrop Brand of Aprotinin; Kontrykal; Kontrikal; Iniprol; Dilmintal; Contrykal; Contrical; Bovine Pancreatic Trypsin InhibitorDrugs* : TRASYLOL
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
recombinant Kunitz protease inhibitor  0   *Aprotinin *Recombinant Proteins. Ann Thorac Surg 1996 Apr;61(4):1223-30
tachocomb  0   *Fibrinogen *Aprotinin *Thrombin Drug Combinations Hemostasis, Surgical. J Cardiovasc Surg (Torino) 1994 Dec;35(6 Suppl 1):169-70
aprotinin, desprolyl(2)-arginyl(15)  0   *Aprotinin Recombinant Proteins Kallikreins/antagonists & inhibitors. J Appl Physiol 1994 Dec;77(6):2675-80
(homoserine lactone-52)-52,53-seco-BPTI  0   *Homoserine *Aprotinin. J Mol Recognit 1994 Mar;7(1):39-46
recombinant neutrophil elastase inhibitor R-020  0   *Aprotinin *Recombinant Proteins. Inflammation 1994 Aug;18(4):337-47
aprotinin, desprolyl(2)-valyl(15)-leucyl(17)  0   *Aprotinin. Bioseparation 1992-93;3(6):365-72
preproaprotinin  0   *Aprotinin *Protein Precursors. J Mol Biol 1993 Aug 20;232(4):1176-96
Eupergit-aprotinin  0   *Aprotinin. J Chromatogr 1990;510:239
spleen protease inhibitor II  0   *Aprotinin. Biol Chem Hoppe Seyler 1989;370(10):1085
aprotinin, Arg(15)-Glu(52)  114264-91-4   *Aprotinin Recombinant Proteins. Biol Chem Hoppe Seyler 1988;369 Suppl:27
FTCH hemostatic  0   *Collagen *Fibrinogen *Aprotinin *Thrombin Drug Combinations. Ann Surg 1987;205(4):432
circular bovine pancreatic trypsin inhibitor  0   *Aprotinin *Peptides, Cyclic. Eur J Biochem 1985;152(2):429
trasylol, Arg(15)  0   *Aprotinin. Eur J Biochem 1984;144(1):185
technetium Tc 99m aprotinin  0   *Aprotinin *Organotechnetium Compounds. Nuklearmedizin 1984;23(1):22
gordox  52229-70-6   *Aprotinin Trypsin Inhibitors. Ther Hungar 23(1):27;1975
tsalol  56590-44-4   *Aprotinin. Probl Gematol Pereliv Krovi 18(2):52;1973
Antagosan  9050-74-2   *Aprotinin *Urokinase-Type Plasminogen Activator. Arzneimittelforsch 21(10):1430;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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