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Sweetening Agents

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Definition: Substances that sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. (From Random House Unabridged Dictionary, 2d ed)  D25-26 qualif    Other names Sugar Substitutes; Artificial Sweeteners; Sweetening Agent; Sweeteners, Artificial; Sweetener, Artificial; Sweetener; Sugar Substitute; Substitutes, Sugar; Substitute, Sugar; Artificial Sweetener; Agents, Sweetening; Agent, Sweetening; Sweeteners
Substances having this pharmacologic action: trichlorosucrose; invert sugar; Stevia; monellin protein, Dioscoreophyllum cumminsii; thaumatin protein, plant; Lactose; Aspartame; Saccharin; Sorbitol; Sucrose; Xylitol; Dietary Sucrose; Maltose; Mannitol; Fructose; Glucose; Cyclamates; Molasses; stevioside; lactitol
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(N-(3-(3-hydroxy-4-methoxyphenyl) propyl)-alpha-aspartyl)-L-phenylalanine 1-methyl ester  0   *Dipeptides Sweetening Agents. Food Chem Toxicol. 2011 Nov;49 Suppl 1():S8-29
11-oxo-mogroside V  0   *Triterpenes Sweetening Agents. Cancer Lett 2003 Jul 30;198(1):37-42
aspartyl-alanine fenchyl ester  0   *Dipeptides *Norbornanes Sweetening Agents. J Agric Food Chem 2001 Oct;49(10):5013-8
abrusoside A methyl ester  0   *Saponins *Triterpenes Sweetening Agents. Org Lett 1999 Jul 29;1(2):223-4
neotame  0   *Dipeptides Sweetening Agents Food Additives. World Rev Nutr Diet 1999;85:52-7
osladin  33650-66-7   *Saponins Sweetening Agents. Adv Exp Med Biol 1996;405:25-36
SC 45647  0   *Guanidines Sweetening Agents. Nature 1996 Jun 27;381(6585):796-800
cellobiofructose  0   *Trisaccharides Sweetening Agents. Ann N Y Acad Sci 1995 Mar 31;750:321-4
gentiobiofructose  0   *Trisaccharides Sweetening Agents. Ann N Y Acad Sci 1995 Mar 31;750:321-4
4,4',6,6'-tetrachloro-4,4',6,6'-tetradeoxygalactotrehalose  53684-69-8   Trehalose/*analogs & derivatives Sweetening Agents. Carbohydr Res 1994 Nov 15;264(2):319-25
brazzein protein, Pentadiplandra brazzeana  0   *Plant Proteins Sweetening Agents. FEBS Lett 1994 Nov 21;355(1):106-8
hydrangenol-4'-O-glucoside  0   *Glucosides *Isocoumarins Sweetening Agents. Chung Kuo Chung Yao Tsa Chih 1994 May;19(5):293-5,320
hydrangenol-8-O-galactoside  0   *Galactosides *Isocoumarins Sweetening Agents. Chung Kuo Chung Yao Tsa Chih 1994 May;19(5):293-5,320
3,3'-dideoxytrehalose  0   Trehalose/*analogs & derivatives Sweetening Agents. Carbohydr Res 1994 Feb 17;254:281-7
selligueain A  152378-18-2 8,14-Methano-2H,14H-1-benzopyrano(7,8-d)(1,3)benzodioxocin-3,5,11,13,15-pentol, 4-(3,4-dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-8-yl)-3,4-dihydro-2,8-bis(4-hydroxyphenyl)-, (2R-(2alpha,3alpha,4beta(2R*,3S*),8beta,14beta,15R*))  *Proanthocyanidins Sweetening Agents. J Nat Prod 1993 Sep;56(9):1532-8
periandrin V  152464-84-1   *Triterpenes Sweetening Agents. Phytochemistry 1993 Sep;34(2):405-8
NC 174  138460-25-0   *Acetic Acids *Guanidines Sweetening Agents. J Mol Recognit 1992 Dec;5(4):173-9
mabinlin protein, Capparis masaikai  0   *Plant Proteins Sweetening Agents. Biochim Biophys Acta 1993 Oct 6;1202(2):277-80
alitame  80863-62-3   *Dipeptides Sweetening Agents. J Am Diet Assoc 1993 July;93(7):816-21
cyclocarioside A  146109-34-4 alpha-L-Mannopyranoside, (3beta,12beta,24R)-3-((5-O-acetyl-alpha-L-arabinofuranosyl)oxy)-20,24-epoxy-25-hydroxy-dammaran-12-yl 6-deoxy  *Saponins *Triterpenes Drugs, Chinese Herbal Sweetening Agents. Yao Hsueh Hsueh Pao 1992;27(11):841-4
mabilin II protein, Capparis masaikai  0   *Plant Proteins Sweetening Agents. Eur J Biochem 1993 Jan 15; 211(1-2):281-7
N-(4-cyanophenyl)-N'-(2-carboxyethyl)urea  74390-15-1   *Phenylurea Compounds beta-Alanine/*analogs & derivatives Sweetening Agents. J Med Chem 1992 May 15;35(10):1747-51
steviolbioside  41093-60-1   *Diterpenes, Kaurane Sweetening Agents Stevia. Chem Pharm Bull (Tokyo) 1991 Dec;39(12):3172-4
Adentol  0   *Sugar Alcohols Sweetening Agents. Stomatol Glas Srb 1991 Aug-Oct;37(4):409-24
periandradulcin C  135545-90-3 beta -D-Glucopyranosiduronic acid, (3beta,22beta)-22-hydroxy-25-oxoolean-18-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-beta-D-glucopyranosyl-(1-2)  *Saponins Oleanolic Acid/*analogs & derivatives Sweetening Agents. Chem Pharm Bull (Tokyo) 1991;39(3):566
periandradulcin B  135545-89-0 beta- D-Glucopyranosiduronic acid, (3beta,22beta)-22-hydroxy-25-oxoolean-12-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-beta-D-xylopyranosyl-(1-2)  *Saponins Oleanolic Acid/*analogs & derivatives Sweetening Agents. Chem Pharm Bull (Tokyo) 1991;39(3):566
periandradulcin A  135545-88-9 beta-D-Glucopyranosiduronic-acid, (3beta,20beta,22beta)-29-hydroxy-22-((4-hydroxy-3,5-dimethoxybenzoyl)oxy)-25-oxoolean-18-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-beta-D-xylopyranosyl-(1-2)  *Saponins Oleanolic Acid/*analogs & derivatives Sweetening Agents. Chem Pharm Bull (Tokyo) 1991;39(3):566
Sweetrex  37370-41-5   *Fructose *Glucose Sweetening Agents. Pharm Res 1991;8(3):336
monellin, Asn(22)-Gln(25)-Asn(26)-A-chain-Asn(49)-Glu(50)-B-chain  0   *Plant Proteins Sweetening Agents. Agric Biol Chem 1990;54(12):3157
curculin  0   *Plant Proteins Sweetening Agents. J Biol Chem 1990;265(26):15770
leucrose  7158-70-5   *Disaccharides Sweetening Agents. J Nutr 1989;119(7):971
polypodoside A  119784-25-7 Cholest-7-en-6-one, 3-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-26-((6-deoxy-alpha-L-mannopyranosyl)oxy)-22,26-epoxy-, (3beta,5alpha,22S,25R,26S)  *Glycosides *Pregnenes Sweetening Agents Polypodium. J Nat Prod 1988;51(6):1166
rubusoside  64849-39-4   *Glucosides *Diterpenes, Kaurane Sweetening Agents. Biomed Environ Mass Spectrom 1988;15(4):211
glycyrrhetyl 3-monoglucuronide  34096-83-8   Glycyrrhetinic Acid/*analogs & derivatives Glycyrrhiza Sweetening Agents. Chem Pharm Bull (Tokyo) 1986;34(12):4978
oxime V  59691-20-2 1,4-Cyclohexadiene-1-carboxaldehyde, 4-(methoxymethyl)-, oxime, (E)  *Cyclohexenes Sweetening Agents. Drug Chem Toxicol 1985;8(4):195
hernandulcin  95602-94-1 2-Cyclohexen-1-one, 6-(1-hydroxy-1,5-dimethyl-4-hexenyl)-3-methyl-, (S-(R*,R*))  *Sesquiterpenes Sweetening Agents. Science 1985;227(4685):417
fungitetraose  13133-07-8 alpha-D-Glucopyranoside, O-beta-D-fructofuranosyl-(2-1)-O-beta-D-fructofuranosyl-(2-1)-beta-D-fructofuranosyl  *Oligosaccharides Sweetening Agents. J Dent Res 1984;63(11):1293
neosugar  88385-81-3   *Oligosaccharides Sweetening Agents. J Nutr 1984;114(9):1574
mogroside IV  89590-95-4   *Triterpenes Sweetening Agents. Yakugaku Zasshi 1983;103(11):1151
mogroside V  88901-36-4   *Triterpenes Sweetening Agents Momordica. Yakugaku Zasshi 1983;103(11):1151
mogroside VI  89590-98-7   *Triterpenes Sweetening Agents. Yakugaku Zassh 1983;103(11):1151
coupling sugar  75536-70-8 Coupling sugar  *Polysaccharides Sweetening Agents. Nippon Shishubyo Gakkai Kaishi 1980;22(1):55
4-chlorokynurenine  75802-84-5 Benzenebutanoic acid, alpha,2-diamino-4-chloro-gamma-oxo-, (+-)  Kynurenine/*analogs & derivatives Sweetening Agents. J Agric Food Chem 1980;28(6):1338
glucosylsucrose  13101-54-7 alpha-D- Glucopyranoside, beta-D-fructofuranosyl O-alpha-D-glucopyranosyl-(1-4)  *Trisaccharides Sweetening Agents. Caries Res 1980;14(5):239
6-chlorotryptophan  17808-35-4   Tryptophan/*analogs & derivatives Sweetening Agents. Arch Biochem Biophys 1980;203(1):161
rebaudioside A  58543-16-1   *Diterpenes, Kaurane Sweetening Agents. Experientia 1980;36(5):519
perillartine  138-91-0 4-(1-methylethenyl)-1-cyclohexene-1-carboxaldehyde oxime (E)  *Oximes *Monoterpenes *Cyclohexenes Sweetening Agents. J Med Chem 1980;23(3):308
hydrangenol  480-47-7 3,4-dihydro-8-hydroxy-3-(4-hydroxyphenyl)-1H-2-benzopyran-1-one  *Isocoumarins Sweetening Agents Hydrangeaceae. Yakugaku Zasshi 1979;99(6):683
Palatinit  64519-82-0   *Disaccharides *Sugar Alcohols Sweetening Agents.
Pharma Action Cariogenic Agents 		Caries Res 1979;13(6):301; Caries Res 1980;14(2):61; Dtsch Zahnaerztl Z 33(3):189;1978; Z Lebensm Unters Forsch 168(2):125;1979
Lycasin  9053-46-7   *Sugar Alcohols Sweetening Agents. Caries Res 12(5):250;1978; Caries Res 12(5):256;1978; Caries Res 1980;14(2):67; Dtsch Zahnaerztl Z 32(5) Suppl 1:71;1977; J Biol Buccale 1979;7(3):299; Pharmacol Ther Dent 3(2-4):53;1978; Pharmacol Ther Dent 3(2-4):75;1978; Scand J Dent Res 86(4):248;1978
cycloheptylsulfamate  60900-58-5   *Cyclamates Sweetening Agents. J Pharm Sci 66(6):881;1977
CH 401-Na  59881-19-5 3-(3-hydroxy-4-(3-(3-hydroxy-4-methoxyphenyl)-1-oxopropyl)phenoxy)-1-propanesulfonic acid, monosodium salt  Chalcone/*analogs & derivatives Sweetening Agents. Nahrung 21(2):131;1977
neohesperidin dihydrochalcone  20702-77-6   *Chalcones Hesperidin/*analogs & derivatives Sweetening Agents. J Chromatogr 129:31;1976; Science 198(4320):944;1977
P 4000  553-79-7   *Aniline Compounds Sweetening Agents. J Chem Educ 53(8):521;1976
maltitol  585-88-6 4-O-alpha-D-glucopyranosyl-D-glucitol  *Sugar Alcohols Maltose/*analogs & derivatives Sweetening Agents. Caries Res 1980;14(2):67; Dtsch Zahnaertz Z 32(5)Suppl 1:36;1977; J Agric Food Chem 24(2):287;1976; Nippon Shokakibyo Gakkai Zasshi 71(11):1166;1974; Pharmacol Ther Dent 3(2-4):75;1978
phyllodulcin  480-46-6 3,4-dihydro-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl) 1H-2-benzopyran-1-one  *Isocoumarins Sweetening Agents. Chem Pharm Bull (Tokyo) 23(12):3101;1975; Yakugaku Zasshi 94(9):1167;1974
miraculin protein, Synsepalum dulcificum  0   *Glycoproteins Sweetening Agents. Acta Physiol Scand 97(2):241;1976; J Agric Food Chem 22(4):595;1974
acetosulfam  33665-90-6 3,4-dihydro-6-methyl-1,2,3-oxathiazin-4-one-2,2-dioxide potassium salt  *Thiazines Sweetening Agents. Dtsch Med Wochenschr 99(44):2251;1974; Z Lebensmitt Untersuch Forsch 162(1):37;1976
dulcin  150-69-6   *Phenylurea Compounds Sweetening Agents. Cancer Res 35:3475;1975; J Gen Physiol 66(6):781;1975; Rocz Panstw Zakl Hig 29(3):249;1978; Yakugaku Zasshi 97(1):58;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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