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Protein Synthesis Inhibitors 
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.  enzyme inhib; DF: PROTEIN SYN INHIB    Other names Protein Synthesis Antagonists; Inhibitors, Protein Synthesis; Antagonists, Protein Synthesis; Protein Synthesis Antagonists
Substances having this pharmacologic action: ribosome-inactivating protein type 2, Sambucus; Fusidic Acid; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Neomycin; Anisomycin; Dactinomycin; dianthin proteins, Dianthus caryophyllus; Erythromycin Estolate; Plicamycin; tempol; Pactamycin; S-2-aminoethyl cysteine; 2',5'-oligoadenylate; trichostatin A; Clarithromycin; pokeweed antiviral protein; Cibacron Blue F 3GA; Oxazolidinones; Puromycin; Erythromycin Ethylsuccinate; Sparsomycin; Streptomycin; sordarin; Brefeldin A; alpha-sarcin; linezolid; GEL protein, Gelonium multiflorum; RIP protein, Saponaria officinalis; Chloramphenicol; ranpirnase; Cycloheximide; halofuginone; Emetine; Erythromycin; Methylazoxymethanol Acetate; Amino Acid Chloromethyl Ketones; Olivomycins; Tetracycline; MITF protein, Aspergillus restrictus
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
telithromycin  0   *Ketolides Protein Synthesis Inhibitors RNA, Ribosomal, 23S. 
Pharma Action Anti-Bacterial Agents 		Diagn Microbiol Infect Dis 1997 Jan-Feb;27(1-2):7-12; The Annals of Pharmacotherapy 2002 36:452-64KETEK
picornain 2A, Picornavirus  EC 3.4.22.29   *Cysteine Endopeptidases *Viral Proteins Protein Synthesis Inhibitors Nucleic Acid Synthesis Inhibitors.  J Virol 1988;62(11):4216
cethromycin  0   Protein Synthesis Inhibitors RNA, Ribosomal, 23S *Ketolides. 
Pharma Action Anti-Bacterial Agents 		Antimicrob Agents Chemother 2000 Feb;44(2):447-9
volkensin  91933-11-8 Volkensin  *N-Glycosyl Hydrolases *Plant Lectins Protein Synthesis Inhibitors.  J Biol Chem 1985;260(27):14589
mukF protein, E coli  0   *Escherichia coli Proteins Protein Synthesis Inhibitors.  Mol Gen Genet 1994 Apr;243(2):136-47
CLA protein, Aspergillus clavatus  EC 3.1.27.-   *Fungal Proteins *Ribonucleases Protein Synthesis Inhibitors.  Eur J Biochem 1996 Jul 15;239(2):272-80
PD-S2 protein, Phytolacca dioica  EC 3.2.2.22   *N-Glycosyl Hydrolases *Plant Proteins Protein Synthesis Inhibitors.  Biochim Biophys Acta 1997 Mar 7;1338(1):137-44
Tricholin protein, Trichoderma viride  0   *Fungal Proteins Protein Synthesis Inhibitors.  J Antibiot (Tokyo) 1994 Jul;47(7):799-805
momorgrosvin protein, Siraitia grosvenorii  EC 3.2.2.22   Protein Synthesis Inhibitors *N-Glycosyl Hydrolases *Plant Proteins.  Life Sci. 2001 Jan 5;68(7):773-84