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Gentamicins

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Definition: A complex of three different closely related aminoglycoside sulfates, Gentamicins C1, C2, and C1(subA), obtained from Micromonospora purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit protein synthesis (GENETIC TRANSLATION).     
Pharmacological Action Anti-Bacterial Agents; Protein Synthesis Inhibitors
Examples Sisomicin 		Other names Gentamycin; Gentamicin Sulfate (USP); Gentacycol; Garamycin; G-Myticin; Gentavet; Sulfate, Gentamicin; G Myticin; Genticin; Gentamycins; Gentamicin Sulfate; Gentamicin; GMyticinDrugs* : APOGEN; U-GENCIN; GENOPTIC; GENTAFAIR; GARAMYCIN; GENTAMICIN; GENTACIDIN; GENTAK; GENTAMICIN SULFATE; PRED-G; BRISTAGEN; GENTAMICIN SULFATE IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER; ISOTONIC GENTAMICIN SULFATE IN PLASTIC CONTAINER
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
etimicin sulfate  0   *Gentamicins. J Toxicol Sci 2010;35(4):479-84
N-((2-sulfo)-9-fluorenylmethoxycarbonyl)(3)gentamicin C(1)  0   *Fluorenes *Gentamicins. J Med Chem 2002 Sep 12;45(19):4264-70
Chen medium  0   HEPES *Amino Acids *Chondroitin Sulfates *Gentamicins Culture Media, Serum-Free. Cornea 2001 Jul;20(5):501-4
gentamicin C  11097-82-8   *Gentamicins. Audiology 12(5):337;1973
Ligenten  0   *Quaternary Ammonium Compounds *Gentamicins *Lidocaine Drug Combinations Gels. Urol Nefrol (Mosk) 1994 May-Jun;(3):14-7
Optisol  97794-22-4   *Chondroitin Sulfates *Dextrans *Gentamicins Complex Mixtures Culture Media, Serum-Free. Invest Opthalmol Vis Sci 1992 Jul;33(8):2454-8
betamethasone dipropionate, fluocinonide, gentamicin, panthenol drug combination  0   *Fluocinonide *Gentamicins Betamethasone/*analogs & derivatives Drug Combinations Pantothenic Acid/*analogs & derivatives. Vestn Dermatol Venerol 1990;(12):34
gentisone HC  123902-40-9   *Gentamicins *Hydrocortisone Drug Combinations. Clin Otolaryngol 1988;13(2):121
protegentin  0   Erythromycin Gentamicins Serine Endopeptidases Ointments. Vestn Otorinolaringol 1988;(1):50
K-Sol preserving medium  0   *HEPES *Chondroitin Sulfates Gentamicins Tissue Preservation. Br J Ophthalmol 1986;70(11):860
sulmycin-implant  0   *Collagen *Gentamicins Drug Implants. Unfallchirurgie 1986;12(3):125
2'-guanidyl-2'-deaminogentamicin C1  82089-23-4   *Gentamicins. Arch Toxicol Suppl 1984;7:455
1-deaminogentamicin C2  86362-50-7 alpha-D-ribo-Heptopyranoside, 6-amino-3-((3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl)oxy)-2-hydroxycyclohexyl 2,6-diamino-2,3,4,6,7-pentadeoxy-, tetrahydrochloride, (1R-(1alpha,2beta,3alpha,6beta))  *Gentamicins. J Antibiot (Tokyo) 1983;36(3):250
Su-2 complex  66065-96-1 D-myo-Inositol, O- 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl-(1-4))-3-amino-2,3-dideoxy  *Gentamicins. J Antibiot (Tokyo) 1982;35(4):385
2-hydroxysagamicin  77052-96-1 D-Streptamine, O-2-amino-2,3,4,6--tetradeoxy-6-(methylamino)-alpha-D-erythro-hexopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-, (2xi)  *Gentamicins. J Antibiot (Tokyo) 1982;35(1):94
UK-4  76792-45-5   *Gentamicins. J Antibiot (Tokyo) 1980;33(11):1383
N(1)-(4-amino-2-hydroxy-1-oxobutyl)sagamicin  56824-15-8 D-Streptamine, O-2-amino- 2,3,4,6-tetradeoxy-3-(methylamino)-alpha-D-erythro-hexopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-N1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-, (S)  *Gentamicins. J Antibiot 1980;33(11):1383
gentamicin A  13291-74-2   *Gentamicins. J Antibiot (Tokyo) 1980;33(11):1380
antibiotic JI 20B  51846-98-1   *Gentamicins. Annu Rev Microbiol 1980;34:537; J Chem Soc (Perkin I) 10:1126;1976
antibiotic JI 20A  51846-97-0   *Gentamicins. Annu Rev Microbiol 1980;34:537; J Chem Soc (Perkin I) 10:1126;1976
gentamicin-polymethylmethacrylate bead  0   *Gentamicins *Methylmethacrylates. Rozhl Chir 1981;60(11):777; S Afr Med J 1981;59(25):885
antibiotic complex JI-20  56592-33-7 Antibiotic JI 20  *Gentamicins. Annu Rev Microbiol 1980;34:537; J Chem Soc (Perkin I) 10:1126;1976
monotrifluoroacetyl gentamicin  54667-98-0 D-Streptamine, O- 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6)-O-(2,3,4,6,7-pentadeoxy-6-(methylamino)-2-((trifluoroacetyl)amino)-alpha-D-ribo-heptopyranosyl-(1-4))-2-deoxy  *Gentamicins. Anal Biochem 1980;104(1):51
gentamicin B  36889-15-3 O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl)-3-(methylamino)-beta-L-arabinopyranosyl-(1-6)-2-deoxy-D-streptamine  *Gentamicins. Arzneim Forsch 1979;29(11):1695
3-N-chloroacetylgentamicin  0   *Gentamicins. J Antibiot (Tokyo) 32(11):1147;1979
betamethasone 17-valerate, clioquinol, gentamicin, tolnaftate drug combination  0   *Betamethasone 17-Valerate *Gentamicins *Clioquinol *Tolnaftate Drug Combinations. Actas Dermosifiliogr 70(5-6):407;1979
isepamicin  58152-03-7 D-Streptamine, O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)  Gentamicins.
Pharma Action Anti-Bacterial Agents 		Antimicrob Agents Chemother 14(2):178;1978; Antimicrob Agents Chemother 14(5):786;1978; Antimicrob Agents Chemother 1979;16(4):491
gentamicin X(2)  36889-17-5 D-Streptamine, O-2-amino -2-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-2-deoxy  Gentamicins. J Chem Soc (Perkin Trans I) 10:1097-1113;1976
antibiotic G 418  49863-47-0 O-2-amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-D-streptamine  *Gentamicins.
Pharma Action Amebicides ; Coccidiostats 		Am J Vet Res 38(9):1293;1977; Antimicrob Agents Chemother 7(6):811;1975; Arzneim Forsch 1979;29(11):1695
diprogenta  76391-73-6 Pregna-1,4-diene-3,20-dione, 9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11beta,16beta)-, mixt. with gentamicin sulfate (salt)  *Gentamicins Betamethasone/*analogs & derivatives Drug Combinations. Curr Therap Res 16(6):581;1974
6'-amino-6'-deoxygentamicin A  53607-78-6   *Gentamicins. J Med Chem 17(9):1030;1974

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