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Ribosome Inactivating Proteins, Type 1

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Definition: Ribosome inactivating proteins consisting of only the toxic A subunit, which is a polypeptide of around 30 kDa.     
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
alpha-luffin protein, Luffa cylindrica  0   *Plant Proteins *Ribosome Inactivating Proteins, Type 1. Acta Biochim Biophys Sin (Shanghai). 2010 Aug;42(8):585-92
curcin protein, Jatropha curcas  0   *Ribosome Inactivating Proteins, Type 1. Acta Biochim Biophys Sin (Shanghai) 2006 Sep;38(9):663-8
IB4-saporin conjugate  0   *Lectins *Ribosome Inactivating Proteins, Type 1 Cytotoxins. Brain Res. 2004 Dec 10;1029(1):65-76Brain Res. 2004 Dec 10;1029(1)
ribosome-inactivating protein, Hordeum vulgare  EC 3.2.2.22   *Ribosome Inactivating Proteins, Type 1. Bioconjug Chem 1990 Sep-Oct;1(5):331-6
momordin-a (protein), Momordica charantia  0   *Ribosome Inactivating Proteins, Type 1. Biosci Biotechnol Biochem. 1993 Jul;57(7):1141-4
HuM195-gelonin  0   *Antibodies, Monoclonal *Ribosome Inactivating Proteins, Type 1. Biol Blood Marrow Transplant 2003 Jun;9(6):364-72
substance P-saporin  0   *Ribosome Inactivating Proteins, Type 1 Substance P/*analogs & derivatives. J Neurosci 2002 Oct 15;22(20):9086-98
agrostin protein, Agrostemma  0   *Ribosome Inactivating Proteins, Type 1. Int J Oncol 2001 Jul;19(1):137-41
SSP-SAP fusion protein, recombinant  0   *Recombinant Fusion Proteins *Ribosome Inactivating Proteins, Type 1. J Neurosci 2002 May 1;22(9):3755-64
anti-VAChT antibody-saporin conjugate immunotoxin  0   *Antibodies *Ribosome Inactivating Proteins, Type 1 Immunotoxins. J Neurosci 2002 Mar 15;22(6):2265-73
hypocretin-2-saporin conjugate  0   *Neuropeptides *Toxins, Biological *Ribosome Inactivating Proteins, Type 1 Immunotoxins. J Neurosci 2001 Sep 15;21(18):7273-83
dermorphin-saporin  0   *Opioid Peptides *Ribosome Inactivating Proteins, Type 1. J Neurosci 2001 Jul 15;21(14):5281-8
cholera toxin B-saporin conjugate  0   *Cholera Toxin *Ribosome Inactivating Proteins, Type 1. J Neurosci 2000 Dec 15;20(24):9215-23
panaxagin protein, Panax ginseng  0   *Plant Proteins Ribonucleases Ribosome Inactivating Proteins, Type 1. Life Sci. 2001 Jan 5;68(7):739-49
quinqueginsin protein, Panax quinquefolium  0   *Plant Proteins Panax Ribosome Inactivating Proteins, Type 1. Biochem Biophys Res Commun 2000 Mar 5;269(1):203-8
trichomaglin  EC 3.2.2.-   *Ribosome Inactivating Proteins, Type 1. Biochem Mol Biol Int 1999 Feb;47(2):185-93
sechiumin protein, Sechium edule  0   *Ribosome Inactivating Proteins, Type 1. Eur J Biochem 1998 Jul 15;255(2):400-8
pepocin protein, Cucurbita pepo  0   *Ribosome Inactivating Proteins, Type 1. Eur J Biochem 1996 Dec 15;242(3):585-91
TXU-pokeweed antiviral protein, Phytolacca  0   *Immunoconjugates *Ribosome Inactivating Proteins, Type 1. Antimicrob Agents Chemother 1998 Feb;42(2):383-8
ME20.4 IgG-saporin  0   *Antibodies, Monoclonal *Ribosome Inactivating Proteins, Type 1 Immunotoxins. Neuroscience 1997 Nov;81(2):331-43
PD-S2 protein, Phytolacca dioica  EC 3.2.2.22   *Ribosome Inactivating Proteins, Type 1 Protein Synthesis Inhibitors. Biochim Biophys Acta 1997 Mar 7;1338(1):137-44
gypsophilin protein, Gypsophila elegans  0   *Ribosome Inactivating Proteins, Type 1. Biosci Biotechnol Biochem 1997 Feb;61(2):324-31
anti-dopamine beta-hydroxylase immunotoxin  0   *Antibodies, Monoclonal *Ribosome Inactivating Proteins, Type 1 Immunotoxins. Semin Cancer Biol 1996 Apr;7(2):71-7
luffaculin protein, Luffa acutangula  0   *Glycoproteins *Ribosome Inactivating Proteins, Type 1. Gen Pharmacol 1994 Mar;25(2):363-7
192 IgG-saporin  0   *Antibodies, Monoclonal *Ribosome Inactivating Proteins, Type 1.
Pharma Action Immunotoxins ; Cholinergic Agents 		J Neuropathol Exp Neurol 1994 Jan;53(1):95-102
OX7-saporin  0   *Antibodies, Monoclonal *Immunoconjugates *Ribosome Inactivating Proteins, Type 1.
Pharma Action Immunotoxins 		Exp Neurol 1993 Dec;124(2):242-52
basic fibroblast growth factor-saporin mitotoxin, recombinant  0   *Recombinant Fusion Proteins *Fibroblast Growth Factor 2 *Ribosome Inactivating Proteins, Type 1 Cytotoxins. J Cell Physiol 1992 Dec;153(3):483-90
barley lectin  0   *Plant Lectins Ribosome Inactivating Proteins, Type 1. Plant Cell 1990 Apr;2(4):301-13
LRIP-I protein, Luffa cylindrica  0   *Ribosome Inactivating Proteins, Type 1. Aids Res Hum Retroviruses 1991 Dec;7(12):1025-30
AMP2 protein, Mirabilis jalapa  0   *Plant Proteins Ribosome Inactivating Proteins, Type 1. J Biol Chem 1992 Feb 5;267(4):2228-33
AMP1 protein, Mirabilis jalapa  0   *Plant Proteins Ribosome Inactivating Proteins, Type 1. J Biol Chem 1992 Feb 5;267(4):2228-2233
GAP31 protein, Gelonium multiflorum  0   *Ribosome Inactivating Proteins, Type 1. FEBS Lett 1991;291(1):139
TAP 29 protein, Trichosanthes kirilowii  EC 3.2.2.22   *Plant Proteins Ribosome Inactivating Proteins, Type 1. Proc Natl Acad Sci USA 1991;88(15):6570
luffin-b protein, Luffa cylindrica  135494-65-4   *Ribosome Inactivating Proteins, Type 1. Agric Biol Chem 1991;55(1):229
luffin-a protein, Luffa cylindrica  0   *Ribosome Inactivating Proteins, Type 1. J Biochem (Tokyo) 1989;106(6):977
MAP protein, Mirabilis jalapa  EC 3.2.2.22   *Ribosome Inactivating Proteins, Type 1. J Biol Chem 1989;264(12):6629
luteinizing hormone-gelonin conjugate protein, plant  0   *Luteinizing Hormone *Ribosome Inactivating Proteins, Type 1. J Biol Chem 1989;264(6):3089
trichokirin protein, Trichosanthes kirilowii  0   *Glycoproteins *Ribosome Inactivating Proteins, Type 1. Eur J Biochem 1988;176(3):581
bryodin  0   *Ribosome Inactivating Proteins, Type 1 Ribosomes. Biochem J 1986;240(3):659
saporin  EC 3.2.2.22   *Ribosome Inactivating Proteins, Type 1.
Pharma Action Immunotoxins ; Antineoplastic Agents, Phytogenic ; Protein Synthesis Inhibitors 		JNCI 1985;75(1):151
tritin protein, Triticum aestivum  0   *Ribosome Inactivating Proteins, Type 1. Biochim Biophys Acta 1981;654(1):57
GEL protein, Gelonium multiflorum  75037-46-6 Gelonin  *Ribosome Inactivating Proteins, Type 1 Deoxyribonucleases.
Pharma Action Antineoplastic Agents, Phytogenic ; Protein Synthesis Inhibitors 		J Biol Chem 1980;255(14):6947
pokeweed antiviral protein  EC 3.2.2.22   *Ribosome Inactivating Proteins, Type 1 Phytolacca.
Pharma Action Protein Synthesis Inhibitors 		J Biol Chem 1980;255(8):3251
crotin II protein, Croton tiglium  8001-56-7 Crotin  *Ribosome Inactivating Proteins, Type 1. Biochem J 156(1):1;1976; Biochem J 156(1):7;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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