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Haptens

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Definition: Small antigenic determinants capable of eliciting an immune response only when coupled to a carrier. Haptens bind to antibodies but by themselves cannot elicit an antibody response.     
Examples p-Azobenzenearsonate; Cardiolipins; Dinitrochlorobenzene; Nitrohydroxyiodophenylacetate; Picryl Chloride 		Other names Contact Sensitizing Agents; Agents, Contact-Sensitizing; Contact-Sensitizing Agents
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
O,O-dimethyl-O-(4-(carboxyl)phenyl)phosphorothiate  0   *Organothiophosphorus Compounds Haptens. J AOAC Int. 2011 Nov-Dec;94(6):1911-7
3-(4-(dimethoxy-O-phosphorothioyl)phenyl)propanoic acid  0   *Organothiophosphorus Compounds Haptens. J AOAC Int. 2011 Nov-Dec;94(6):1911-7
N-sulfanil-4-aminobutyric acid  0   *Aminobutyric Acids *Sulfanilic Acids Haptens. Wei Sheng Yan Jiu. 2009 Nov;38(6):729-32
mercuric mercaptide of penicillenic acid  0   *Organomercury Compounds Haptens. J Immunol Methods. 2010 Feb 28;353(1-2):1-7
celangulin V  0   *Haptens. J Agric Food Chem. 2006 Oct 4;54(20):7600-5
hapten 7  0   *Haptens. Bioorg Med Chem. 2001 Dec;9(12):3185-95
hapten 44  0   *Haptens. Bioorg Med Chem. 2001 Dec;9(12):3185-95
17-hydroxy-11-(3'-sulfanylpropyl)oxy-estra-1,3,5(10)-trien-3-yl sulfamate  0   *Estrenes *Sulfonic Acids Haptens. Steroids 1999 Jul;64(7):460-71
6-(N-(4-nitrobenzyl)-N-propyl-N-oxido)aminocaproic acid  0   *Aminocaproic Acids Haptens. Bioorg Med Chem 1999 Jun;7(6):1145-50
4-ethoxymethylene-2-phenyl-2-oxazoline-5-one  0   *Oxazoles Haptens. J Immunol Methods 1999 Apr 22;224(1-2):151-60
4-acetylbenzoic acid  586-89-0   *Benzoic Acids Haptens. J Immunol Methods 1998 Nov 1;220(1-2):105-14
3,7-dihydroxy-17-oxoandrost-5-en-19-al 19-(0-carboxymethyl)oxime  0   *Androstenols *Oximes Haptens. Steroids 1998 Sep;63(9):454-8
1-hydroxy-25,26,27-trinorvitamin D3 24-oic acid  0   Cholecalciferol/*analogs & derivatives Haptens. Biol Pharm Bull 1997 Sep;20(9):948-53
25-hydroxyvitamin D3 3-hemisuccinate  0   *Succinates Cholecalciferol/*analogs & derivatives Haptens. Biol Pharm Bull 1997 Sep;20(9):948-53
17-hydroxyandrost-4-ene-3,15-dione-15-(O-carboxymethyl)oxime  0   Testosterone/*analogs & derivatives Haptens. Steroids 1996 Nov;61(11):634-8
13,14-epoxyabietic acid  0   *Epoxy Compounds *Diterpenes, Abietane Haptens. Contact Dermatitis 1996 Oct;35(4):201-7
SR 120684A  0   *Aniline Compounds *Succinates Haptens. J Pharm Biomed Anal 1996 May;14(7):783-91
3beta,17-dihydroxy-20-oxopregn-5-en-19-al-19-(O-carboxymethyl)oxime  0   *Pregnenes Haptens. Steroids 1994 Dec;59(12):696-701
5-((4-(((4-methoxyphenyl)-oxoacetyl) methylamino)phenyl)methylamino)-5-oxopentanoic acid  0   *Glutarates *Phenylenediamines Haptens. Bioorg Med Chem 1994 Jun;2(6):521-8
5-((4-(((4-methoxyphenyl)oxoacetyl)amino)phenyl)amino)-5-oxopentanoic acid  0   *Glutarates *Phenylenediamines Haptens. Bioorg Med Chem 1994 Jun;2(6):521-8
arsanilic acid hapten-bovine gamma globulin  0   *Arsanilic Acid *gamma-Globulins Haptens. Immunol Lett 1994 Mar;39(3):231-4
4-diazophenylphosphocholine  69731-89-1   *Azo Compounds Phosphorylcholine/*analogs & derivatives Haptens. Int Immunol 1994 Apr;6(4):561-8
4-nitrophenyl-6-(O-phosphocholine)hydroxyhexanoate  73785-43-0   *Caproates Phosphorylcholine/*analogs & derivatives Haptens. Int Immunol 1994 Apr;6(4):561-8
methyl 13,14-epoxyabietate  55154-40-0   *Epoxy Compounds *Diterpenes, Abietane Haptens. Chem Res Toxicol 1994 Mar-Apr;7(2):260-6
oxazolone-glycine  0   Glycine/*analogs & derivatives Oxazolone/*analogs & derivatives Haptens. Int Arch Allergy Immunol 1993;102(1):94-100
2,4,6-trinitrophenyl-lysine  15113-66-3   *Trinitrobenzenes Lysine/*analogs & derivatives Haptens. Int Arch Allergy Immunol 1993;102(1):94-100
3-aminopropyl 6-deoxy-2-O-(3-O-(2-O-methyl-(4-O-methylrhamnopyranosyl)fucopyranosyl)rhamnopyranosyl)talopyranoside  148404-60-8   *Oligosaccharides Haptens. Carbohydr Res 1993 Mar 17;241:153-64
3-(1-piperidinyl)propionic acid  26371-07-3   *Piperidines Haptens. Acta Tropica 1992 Apr;50(4):353-6
4-methyl-1-piperazine carboxylic acid  58226-19-0   *Piperazines Haptens. Acta Tropica 1992 Apr;50(4):353-6
4-aminophthalate  5434-21-9   *Phthalic Acids Haptens. J Natl Med Assoc 1991 Oct; 83(10):901-4
neoarsphenamine  457-60-3   Arsphenamine/*analogs & derivatives Haptens.
N-epsilon-trifluoro-lysine  0   Lysine/*analogs & derivatives Haptens. Br J Anaesth 1991 Dec;67(6):722
EOTUBE  128817-30-1 Glycine, N,N'-(1-((4-((((2-hydroxyethyl)amino)thioxomethyl)amino)phenyl)methyl)-1,2-ethanediyl)bis(N-(carboxymethyl))  Edetic Acid/*analogs & derivatives Haptens. Cancer Res 1991;51(24):6650
7-(3-oxocholest-4-en-2-yl)-5-oxa-4-oxoheptanoic acid  134329-94-5   *Keto Acids *Ketocholesterols Haptens. Steroids 1991;56(4):185
1-O-(15-carboxypentadecyl)-2-O-acetylglycero-3-phosphorylcholine  129879-41-0   Platelet Activating Factor/*analogs & derivatives Haptens. Chem Phys Lipids 1990;53(1):121
6-(2,4-dinitrophenylamino)-1-aminohexyl-6-(4'-azido-2'-nitrophenylamino)hexanoate  120551-21-5   *Azides 6-Aminocaproic Acid/*analogs & derivatives Haptens. Anal Biochem 1989;177(2):392
estradiol-3-O-carboxymethyl ether  41164-36-7   *Methyl Ethers Estradiol/*analogs & derivatives Haptens. Steroids 1988;51(5-6):519
dinitrophenyl-human serum albumin conjugate  0   *Dinitrophenols *Serum Albumin Haptens. Immunol Commun 1982;11(5):337
26-(2'-aminoethylthio)tetrahydroteleocidin A-2  117490-45-6   *Lyngbya Toxins Haptens. Carcinogenesis 1988;9(9):1629
4-aminophenylphosphonic acid methyl-1,2,2-trimethylpropyl diester  114767-15-6   *Organophosphorus Compounds Haptens. Z Naturforsch (C) 1988;43(3-4):167
N-(2-dansylaminoethyl)amphetamine  108303-15-7   *Amphetamines *Dansyl Compounds Haptens. Nippon Hoigaku Zasshi 1986;40(6):799
2,4-dinitrophenylaminocaproyltyrosine  104077-24-9   *Dinitrobenzenes Tyrosine/*analogs & derivatives Haptens. Mol Immunol 1986;23(7):769
trinitrophenylglutamyllysine  123774-73-2   *Dipeptides *Trinitrobenzenes Haptens. J Clin Invest 1986;78(3):784
trinitrophenyl-lipopolysaccharide  0   *Lipopolysaccharides Antigens, T-Independent Endotoxins Escherichia coli Haptens Trinitrobenzenes. Toxicol Appl Pharmacol 1986;83(3):456
N-(6-(2-carboxy-4,6-dinitrophenylamino)hexanoyl)glucopyranosylamine  103083-55-2   *Dinitrobenzenes Haptens. Immunobiology 1985;170(5):412
9,10,11,12,14,15-hexahydroleukotriene C4  78340-36-0   SRS-A/*analogs & derivatives Haptens. Adv Prostaglandin Thromboxane Leukotriene Res 1985;15:29
amiloride caproate  101330-34-1   Amiloride/*analogs & derivatives Haptens. Am J Physiol 1986;250(1 Pt 1):C165
11-progesteryl-2-succinoyltyramine-4-(10-methyl)acridinium-9-carboxylate  99195-33-2   *Acridines Progesterone/*analogs & derivatives Haptens. Clin chem 1985;31(10):1664
dinitrophenol-ovalbumin  0   *Dinitrophenols *Ovalbumin Haptens. Respiration 1985;47(2):138
diglutamylphosphatidylethanolamine dihexadecyl ether  93552-53-5 L-alpha-Glutamine, N2-L-alpha-glutamyl-N-(7-(hexadecyloxy)-4-hydroxy-3,5,9-trioxa-4-phosphapentacos-1-yl)-, (3alpha,5beta,7alpha,12alpha,24xi)  *Phospholipid Ethers Haptens. Mol Immunol 1984;21(9):801
3,6-di-O-methyl-beta-glucopyranosyl-(1-4)-2,3-di-O-methyl-alpha-rhamnopyranose  89821-88-5 alpha-L-Mannopyranose, 6-deoxy-4-O-(3,6-di-O-methyl-beta-D-glucopyranosyl)-2,3-di-O-methyl-, (2S-trans)  *Disaccharides Epitopes Antigens, Bacterial Haptens Vaccines, Synthetic. J Infect Dis 1984;150(3):311
2,4-dinitrophenyl keyhole limpet hemocyanin  0   *Hemocyanin Antigens Haptens. Immunology 1984;53(1):97
polyandroalbumin  0   *Serum Albumin Androstenedione/*analogs & derivatives Haptens. Aust Vet J 1984;61(4):130
5-sulfo-1-naphthoxyacetic acid N-hydroxysuccinimide ester  88924-72-5 1-Naphthalenesulfonic acid, 5-(2-((2,5-dioxo-1-pyrrolidinyl)oxy)-2-oxoethoxy)  *Naphthaleneacetic Acids Haptens. J Immunol 1984;132(1):57
trinitrophenyl-bovine serum albumin  0   *Serum Albumin, Bovine Haptens Trinitrobenzenes. J Pharmacol Methods 1983;9(3):175
trinitrophenyl-ovalbumin  0   *Ovalbumin Haptens Trinitrobenzenes. J Pharmacol Methods 1983;9(3):175
19-O-carboxymethoxyandrostenedione  79524-41-7 Acetic acid, ((3,17-dioxoandrost-4-en-19-yl)oxy)  Androstenedione/*analogs & derivatives Haptens. J Steroid Biochem 1982;17(5):523
dinitrophenyl-bovine serum albumin  0   *Dinitrophenols *Serum Albumin, Bovine Haptens. Hepatology 1982;2(3):328
2-hydroxyethyl-dimethylsulfoxonium  74078-14-1 Sulfoxonium, (2-hydroxyethyl)dimethyl  *Sulfonium Compounds Allergens Bryozoa Haptens Marine Toxins. Toxicon 1982;20(1):307
dinitrophenyl-beta-alanyl-glycyl-glycine  39555-56-1 Glycine, N-(N-(N-(2,4-dinitrophenyl)-beta-alanyl)glycyl)  *Oligopeptides Haptens. Immunology 1982;45(3):545
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