encyclopedia of medical concepts
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Ketocholesterols
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Definition
: Cholesterol substituted in any position by a keto moiety. The 7-keto isomer inhibits 3-hydroxy-3-methylglutaryl-CoA reductase activity and inhibits cholesterol uptake in the coronary arteries and aorta in vitro.
/biosyn /physiol permitted
Other names
Oxocholesterols
Substance
CAS Registry & name
Categories
Source
Drugs
*
G1268267X
0
*Ketocholesterols.
Lipids 2001 Jul;36(7):701-11
S 19159
0
*Ketocholesterols.
J Antibiot (Tokyo) 1998 Oct;51(10):897-901
7-
ketocholesteryl-
3-
oleate
145889-56-1
*Ketocholesterols.
J Neurochem 1995 Nov;65(5):2194-200
5-
hydroxy-
6-
ketocholestanol
0
*Ketocholesterols.
Lipids 1994 Sep;29(9):657-60
7-
(3-
oxocholest-
4-
en-
2-
yl)-
5-
oxa-
4-
oxoheptanoic acid
134329-94-5
*Keto Acids
*Ketocholesterols
Haptens.
Steroids 1991;56(4):185
6-
ketocholestanol
70223-10-8
*Ketocholesterols.
Free Radic Res Commun 1990;8(3):185
SC-
31769
67147-65-3 Androst-
5-
en-
7-
one, 3-
hydroxy-
17-
((4-
methylpentyl)oxy)-
, (3beta,17beta)
*Ketocholesterols.
Proc Nat Acad Sci 75(4):1877;1978
7-
ketocholesterol
566-28-9 3 beta-
hydroxycholest-
5-
en-
7-
one
*Ketocholesterols
Cholesterol 7-alpha-Hydroxylase/antagonists & inhibitors.
Pharma Action
Enzyme Inhibitors
Adv Exp Med Biol 67:419;1976; Adv Exp Med Biol 82:297;1977; Biochim Biophys Acta 486(2):260;1977; Biochim Biophys Acta 529(3):475;1978; Biochim Biophys Acta 531(3):322;1978; Exp Cell Res 109:253;1977; J Biochem (Tokyo) 1980;87(2):497; J Biol Chem 252(15):5186;1977; J Biol Chem 254(3):715;1979; J Mol Cell Cardiol 10:197;1978; Life Sci 11(15):773;1972; Microvasc Res 16(1):51;1978; Proc Soc Exp Biol Med 151(2):303;1976