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ψ 
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SRS-A

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Definition: A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)  /biosyn /physiol permitted   
Examples Leukotriene C4; Leukotriene D4; Leukotriene E4 		Other names Slow Reacting Substance of Anaphylaxis
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-acetylleukotriene D4  80115-94-2   SRS-A/*analogs & derivatives. Prostaglandins 1992 Jun;43(6):523-32
BAY u9773  0   SRS-A/*analogs & derivatives. Ann N Y Acad Sci 1991;629:402
20,20,20-trifluoroleukotriene E4  131074-64-1   SRS-A/*analogs & derivatives. Arch Biochem Biophys 1990;282(2):333
16-carboxytetranordihyroleukotriene E4  122069-63-0   SRS-A/*analogs & derivatives. Eicosanoids 1990;3(2):75
5-hydroxy-6-mercapto-7,9,11,14-eicosatetraenoic acid  125467-37-0   SRS-A/*analogs & derivatives. Arch Biochem Biophys 1989;275(2):531
16-carboxy-17,18,19,20-tetranor-14,15-dihydro-N-acetylleukotriene E4  114115-52-5   SRS-A/*analogs & derivatives. Prostaglandins 1988;36(3):291
18-carboxy-19,20-dinor-N-acetylleukotriene E4  114115-51-4   SRS-A/*analogs & derivatives. Prostaglandins 1988;36(3):291
CGP 34064A  0   SRS-A/*analogs & derivatives. Adv Prostaglandin Thromboxane Leukotriene Res 1987;17A:519
4-hydroxy-5-((2-carboxyethyl)thio)-6-nonadecenoic acid  95061-94-2   SRS-A/*analogs & derivatives. Prostaglandins Leukotrienes Med 1986;23(1):37
9,10,11,12,14,15-hexahydroleukotriene C4  78340-36-0   SRS-A/*analogs & derivatives Haptens. Adv Prostaglandin Thromboxane Leukotriene Res 1985;15:29
2-norleukotriene D1  88477-96-7   SRS-A/*analogs & derivatives. Prostaglandins 1985;29(1):75
leukotriene F-4 sulfone  84745-89-1 L-Alanine, 3-((1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)sulfonyl)-N-L-gamma-glutamyl-, (R-(R*,S*-(E,E,Z,Z)))  SRS-A/*analogs & derivatives. Prostaglandins 1982;24(6):801
leukotriene F-4  83851-42-7 L-Cysteine, S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-, (R-(R*,S*-(E,E,Z,Z)))  SRS-A/*analogs & derivatives. Biochem Biophys Res Commun 1982;109(3):800
leukotriene E-4 sulfone  82850-11-1 7,9,11,14-Eicosatetraenoic acid, 6-((2-amino-2-carboxyethyl)sulfonyl)-5-hydroxy-, (5S-(5R*,6S*(S*),7E,9E,11Z,14Z))  SRS-A/*analogs & derivatives. Prostaglandins 1982;24(2):279
leukotriene D-4 sulfone  82850-10-0 Glycine, N-(3-((1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)sulfonyl)-L-alanyl)-, (R-(R*,S*-(E,E,Z,Z)))  SRS-A/*analogs & derivatives. Prostaglandins 1982;24(2):279
leukotriene C-4 sulfone  82890-06-0 Glycine, N-(3-((1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)sulfonyl)-N-L-gamma-glutamyl-L-alanyl)-, (R-(R*,S*-(E,E,Z,Z)))  SRS-A/*analogs & derivatives. Prostaglandins 1982;24(2):279
leukotriene D-3  77165-74-3 Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6-pentadecatrienyl)-L-cysteinyl)-, (R-(R*,S*-(E,E,Z)))  SRS-A/*analogs & derivatives Autacoids. J Biol Chem 1981;256(5):2275
leukotriene C-3  77209-77-9 Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6-pentadecatrienyl)-N-L-gamma-glutamyl-L-cysteinyl)-, (R-(R*,S*-(E,E,Z)))  SRS-A/*analogs & derivatives Autacoids. J Biol Chem 1981;256(5):2275
leukotriene C-5  75207-09-9 Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9,12-pentadecapentaenyl)-N-L-gamma-glutamyl-L-cysteinyl)-, (R-(R*,S*-(E,E,Z,Z,Z)))  SRS-A/*analogs & derivatives Eicosapentaenoic Acid/*analogs & derivatives Autacoids. J Biol Chem 1980;255(15):7093
leukotriene C-2  74841-69-3 Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-, (R-(R*,S*-(E,E,E,Z)))  SRS-A/*analogs & derivatives Autacoids. Biochem Biophys Res Commun 1980;94(4):1133

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