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Glycogen Synthase Kinase 3

More information in Books or onNLM PubMed
Definition: A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabolism. It regulates a diverse array of functions such as CELL DIVISION, microtubule function and APOPTOSIS.      Other names gsk-3 Gene Product; GSK-3
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
small molecule VP 0.7  0   *Hydrazines *Quinolones Glycogen Synthase Kinase 3/antagonists & inhibitors. J Med Chem. 2011 Dec 22;54(24):8461-70.
2-methyl-5-(3-(4-(methylsulfinyl)phenyl)-1-benzofuran-5-yl)-1,3,4-oxadiazole  0   *Benzofurans *Oxadiazoles Glycogen Synthase Kinase 3/antagonists & inhibitors. J Neurochem. 2011 Dec;119(6):1330-40.
6-bromoindirubin-3'-(O-(2-morpholin-1-ylethyl)oxime)  0   *Indoles *Oximes Glycogen Synthase Kinase 3/antagonists & inhibitors. J Neurosci Res. 2011 Nov;89(11):1802-11.
6-bromoindirubin-3'-(O-(N,N-diethylcarbamyl)oxime)  0   *Indoles *Oximes Glycogen Synthase Kinase 3/antagonists & inhibitors. J Neurosci Res. 2011 Nov;89(11):1802-11.
dibromocantharelline  0   *Indole Alkaloids Glycogen Synthase Kinase 3/antagonists & inhibitors. Chem Biol Drug Des 2011 Mar;77(3):199-205
3-(4-fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione  0   *Indoles *Maleimides Glycogen Synthase Kinase 3/antagonists & inhibitors. Bioorg Med Chem 2010 Sep 15;18(18):6785-95
bisarylmaleimide  0   *Maleimides Glycogen Synthase Kinase 3/antagonists & inhibitors. Org Lett. 2010 Aug 20;12(16):3700-3
TWS 119  0   *Pyrimidines *Pyrroles Glycogen Synthase Kinase 3/antagonists & inhibitors. Proc Natl Acad Sci U S A 2003 Jun 24;100(13):7632-7
6-methyl-N-(3-((3-(1-methylethoxy)propyl)carbamoyl)-1H-pyrazol-4-yl)pyridine-3-carboxamide  0   *Pyrazoles Niacinamide/*analogs & derivatives Glycogen Synthase Kinase 3/antagonists & inhibitors. Brain Res 2009 Nov 3;1236:148-63
NP12  0   *Thiadiazoles Glycogen Synthase Kinase 3/antagonists & inhibitors. Neurobiol Dis. 2009 Sep;35(3):359-67
6,7-dimethoxy-1-(3,4-dimethoxy)benzyl-2-(N-n-octyl-N'-cyano)guanyl-1,2,3,4-tetrahydroisoquinoline  0   *Amidines *Isoquinolines Glycogen Synthase Kinase 3/antagonists & inhibitors. Bioorg Med Chem Lett 2008 Jun 15;18(12):3652-5
2-thio(3-iodobenzyl)-5-(1-pyridyl)-(1,3,4)oxadiazole  0   *Oxadiazoles *Pyridines Glycogen Synthase Kinase 3/antagonists & inhibitors. Biochem Biophys Res Commun 2008 Jul 11;371(4):894-9
cazpaullone  0   *Azepines *Indoles Glycogen Synthase Kinase 3/antagonists & inhibitors. J Med Chem 2008 Apr 10;51(7):2196-207
mjl protein, Drosophila  EC 2.7.1.37   *Drosophila Proteins *Glycogen Synthase Kinase 3. Mol Biol Evol. 2007 Mar;24(3):732-42
N-myristoyl-glycyl-lysyl-glutamyl-alanyl-prolyl-prolyl-alanyl-prolyl-prolyl-glutaminyl-phosphoseryl-proline  0   *Oligopeptides Glycogen Synthase Kinase 3/antagonists & inhibitors. J Pharmacol Exp Ther 2006 Jan;316(1):17-24
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione  0   *Thiadiazoles Glycogen Synthase Kinase 3/antagonists & inhibitors. J Med Chem 2002 Mar 14;45(6):1292-9
6-bromoindirubin-3'-oxime  0   *Indoles *Oximes Glycogen Synthase Kinase 3/antagonists & inhibitors. Nat Med 2004 Jan;10(1):55-63
N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea  0   *Thiazoles Urea/*analogs & derivatives Glycogen Synthase Kinase 3/antagonists & inhibitors. J Biol Chem 2003 Nov 14;278(46):45937-45
Chir 99021  0   *Pyridines *Pyrimidines Glycogen Synthase Kinase 3/antagonists & inhibitors. Diabetes 2003 Mar;52(3):588-95
Chir 98014  0   *Aminopyridines *Pyrimidines Glycogen Synthase Kinase 3/antagonists & inhibitors. Diabetes 2003 Mar;52(3):588-95
DWF12 protein, Arabidopsis  EC 2.7.1.37   *Arabidopsis Proteins *Glycogen Synthase Kinase 3. Plant Physiol 2002 Nov;130(3):1506-15
glycogen synthase kinase 3 beta  EC 2.7.11.1   *Glycogen Synthase Kinase 3.
glycogen synthase kinase 3 alpha  EC 2.7.1.37   *Glycogen Synthase Kinase 3.
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione  0   *Aminophenols *Maleimides Glycogen Synthase Kinase 3/antagonists & inhibitors. Chem Biol 2000 Oct;7(10):793-803
p25 protein, human  0   *Nerve Tissue Proteins Glycogen Synthase Kinase 3. J Hum Genet 1999;44(2):121-2
ATSK11 protein, Arabidopsis  EC 2.7.1.37   *Arabidopsis Proteins Glycogen Synthase Kinase 3. Mol Gen Genet 1994 Feb;242(3):337-45
MsK-3 protein, Medicago sativa  EC 2.7.1.-   *Plant Proteins *Glycogen Synthase Kinase 3. Plant J 1993 Jun;3(6):847-56
MsK-2 protein, Medicago sativa  EC 2.7.1.-   *Plant Proteins *Glycogen Synthase Kinase 3. Plant J 1993 Jun;3(6):847-56
Msk-1 protein, Medicago sativa  EC 2.7.1.37   *Plant Proteins *Glycogen Synthase Kinase 3. Plant J 1993 Jun;3(6):847-56
tau-protein kinase  EC 2.7.11.26   *Glycogen Synthase Kinase 3. Neurosci Lett 1992 Dec 14;148(1-2);202-6
shaggy protein, Drosophila  EC 2.7.1.37   *Drosophila Proteins *Glycogen Synthase Kinase 3. Oncogene 1993 Apr;8(4):841-7
MCK1 protein, S cerevisiae  EC 2.7.11.1   *Saccharomyces cerevisiae Proteins *Glycogen Synthase Kinase 3. Genes Dev 1991;5(4):533

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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