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| Receptors, Purinergic P1 |
| A class of cell surface receptors that prefers ADENOSINE to other endogenous purines. Purinergic P1 receptors are widespread in the body including the cardiovascular, respiratory, immune, and nervous systems. There are at least two pharmacologically distinguishable types (A1 and A2, or Ri and Ra). The methylxanthines, e.g., CAFFEINE, bind to these receptors, but also have other unrelated effects.
| GEN; prefer specifics
| Other names Receptors, Adenosine; Purinergic P1 Receptors; P1 Purinoceptors; Adenosine Receptors; Receptor, Adenosine; Purinoceptors, P1; Purinoceptor, P1; Purinergic P1 Receptor; P1 Receptors, Purinergic; P1 Receptor, Purinergic; Receptor, Purinergic P1; P1 Purinoceptor; Adenosine Receptor; Receptors, Adenosine; Purinergic P1 Receptors; P1 Purinoceptors; Adenosine Receptors
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| Substance | CAS Registry & name | Categories | Source | Drugs*
|
1,3-dipropyl-8-cyclopentylxanthine
| 102146-07-6
|
*Xanthines Receptors, Purinergic P1/antagonists & inhibitors.
|
Life Sci 1987;40(6):555
|
| CGS 21680
| 120225-54-9
|
*Phenethylamines Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists Receptors, Purinergic P2/antagonists & inhibitors.
Pharma Action Antihypertensive Agents
|
J Pharmacol Exp Ther 1989;251(1):47
|
N(6)-cyclopentyladenosine
| 41552-82-3
|
Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists.
|
Naunyn Schmiedebergs Arch Pharmacol 1986;332(2):179
|
8-(4-sulfophenyl)theophylline
80206-91-3
Benzenesulfonic acid, 4-(2,3,6,7-tetrahydro-1,3-dimethyl-2,6-dioxo-1H-purin-8-yl)
|
Theophylline/*analogs & derivatives Receptors, Purinergic P1/antagonists & inhibitors.
|
Life Sci 1981;28(23):2611
|
8-cyclopentyl-1,3-dimethylxanthine
| 35873-49-5
|
Theophylline/*analogs & derivatives Receptors, Purinergic P1/antagonists & inhibitors.
|
Brain Res 1987;417(2):377
|
3,7-dimethyl-1-propargylxanthine
| 14114-46-6
|
Theobromine/*analogs & derivatives Receptors, Purinergic P1/antagonists & inhibitors.
|
Life Sci 1988;43(21):1671
|
| SCH 58261
| 0
|
*Pyrimidines *Triazoles Receptors, Purinergic P1/antagonists & inhibitors.
Pharma Action Neuroprotective Agents
|
J Med Chem 1996 Mar 1;39(5):1164-71
|
1,3-dipropyl-8-(4-sulfophenyl)xanthine
| 89073-57-4
|
*Xanthines Receptors, Purinergic P1/antagonists & inhibitors.
|
Am J Physiol 1987;253(4 Pt 2):H909
|
| istradefylline
| 155270-99-8
|
*Purines Receptors, Purinergic P1/antagonists & inhibitors.
|
Ann Neurol 1998 Apr;43(4):507-13
|
1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine
| 85872-51-1
|
*Xanthines Receptors, Purinergic P1/antagonists & inhibitors.
Pharma Action Antineoplastic Agents
|
Br J Pharmacol 1985;85(1):291
|
N-((1S,trans)-2-hydroxycyclopentyl)adenosine
124555-18-6
Adenosine, N-(2-hydroxycyclopentyl)-, (1S-trans)
Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists.
Pharma Action Antilipemic Agents
|
Clin Sci (Colch) 1993 Jun;84(6):663-9
|
| MRS 1220
| 0
|
*Quinazolines *Triazoles Receptors, Purinergic P1/antagonists & inhibitors.
|
Neuropharmacology 1997 Sep;36(9):1157-65
|
2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide
| 163042-96-4
|
Adenosine/*analogs & derivatives Adenylate Cyclase/antagonists & inhibitors Receptors, Purinergic P1/agonists.
|
J Med Chem 1994 Oct 14;37(21):3614-21
|
1,3-dipropyl-8-(2-(5,6-epoxy)norbornyl)xanthine
| 0
|
*Xanthines Stereoisomerism Receptors, Purinergic P1/antagonists & inhibitors.
|
J Pharmacol Exp Ther 1995 Dec;275(3):1167-76
|
8-cyclopenta-3-(3-fluoropropyl)-1-propylxanthine
| 0
|
Receptors, Purinergic P1/antagonists & inhibitors Fluorine Radioisotopes *Xanthines.
|
J Med Chem 2002 Nov 7;45(23):5150-6
|
2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate
| 0
|
Receptors, Purinergic P1/antagonists & inhibitors *Pyridines.
|
J Membr Biol 2000 Nov 15;178(2):108-13
|
N-(3-tetrahydrofuranyl)-6-aminopurine riboside
| 0
|
*Furans Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists.
|
Br J Pharmacol 1999 Jan;126(1):137-46
|
MRE 3008-F20
| 0
|
Receptors, Purinergic P1/antagonists & inhibitors *Phenylurea Compounds *Triazoles.
|
Bioorg Med Chem Lett 2000 Feb 7;10(3):209-11
|
2-(cyclohexylmethylidenehydrazino)adenosine
| 144348-08-3
|
Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists.
|
Circulation 1996 Oct 1;94(7):1726-32
|
N(6)-(4-sulfophenyl)adenosine
| 0
|
Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists.
|
Br J Pharmacol 1997 Oct;122(3):525-33
|
| MRS 1097
| 0
|
*Dihydropyridines Receptors, Purinergic P1/antagonists & inhibitors.
|
J Med Chem 1996 Jul 19;39(15):2980-9
|
| MSX 2 compound
| 0
|
*Xanthines Receptors, Purinergic P1/antagonists & inhibitors.
|
Neuroreport 1998 Jun 1;9(8):1803-6
|
| purinoceptor RDC8
| 0
|
*Receptors, Purinergic P1.
|
Brain Res 1990;519(1-2):333
|
| purinoceptor RDC7
| 0
|
*Receptors, Purinergic P1.
|
Brain Res 1990;519(1-2):333
|
| KF 17387
| 0
|
*Xanthines Receptors, Purinergic P1/antagonists & inhibitors.
|
Eur J Pharmacol 1996 Oct 17;313(3):237-42
|
3,6-dichloro-2'-isopropyloxy-4'-methylflavone
| 0
|
*Flavonoids Receptors, Purinergic P1/antagonists & inhibitors.
|
Neuropharmacology 1997 Sep;36(9):1157-65
|
| uniblue A
| 34293-80-6
|
*Anthraquinones *Sulfonic Acids Receptors, Purinergic P1/antagonists & inhibitors Receptors, Purinergic P2/antagonists & inhibitors.
|
Br J Pharmacol 1995 Jun;115(3):427-32
|
| WRC 0571
| 0
|
*Norbornanes Adenine/*analogs & derivatives Receptors, Purinergic P1/antagonists & inhibitors.
|
J Pharmacol Exp Ther 1996 Feb;276(2):490
|
2-(3-hydroxy-3-phenyl-1-propyn-1-yl)-5'-N-ethylcarboxamidoadenosine
| 0
|
Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists.
|
Bioorg Med Chem 1997 Dec;5(12):2267-75
|
| KF 20274
| 143394-68-7
|
*Imidazoles Adamantane/*analogs & derivatives Receptors, Purinergic P1/antagonists & inhibitors.
|
J Med Chem 1992 Sep 18;35(19):3578-81
|
| KFM 19
| 133058-72-7
|
*Xanthines Receptors, Purinergic P1/antagonists & inhibitors.
|
Neurosci Lett 1993 Feb 19;150(2):191-4
|
8-dipropyl-8-cyclopentylxanthine
| 0
|
*Xanthines Receptors, Purinergic P1/antagonists & inhibitors.
|
Pharmacol 1997 Jun;80(6):295-300
|
8-butylamino-N(6)-cyclopentyladenosine
| 0
|
Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists.
|
Biochem Pharmacol 1998 Dec 1;56(11):1437-45
|
| CVT 2759
| 0
|
Receptors, Purinergic P1/agonists *Purines.
|
Am J Physiol Heart Circ Physiol 2001 Jan;280(1):H334-43
|
| PD 78416
| 52824-61-0
|
*Pyridines *Thiophenes Receptors, Purinergic P1/agonists.
|
Naunyn Schmiedebergs Arch Pharmacol 1995 Aug;352(2):206-12
|
RS 74513-000
| 0
|
*Thiophenes Receptors, Purinergic P1/agonists.
|
Naunyn Schmiedebergs Arch Pharmacol 1995 Aug;352(2):206-12
|
2-hexyloxyadenosine
| 50257-95-9
|
Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists.
|
Naunyn Schmiedebergs Arch Pharmacol 1996 Feb;353(3):250-60
|
2-(2-phenylethoxy)adenosine
| 131865-79-7
|
Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists.
|
Naunyn Schmiedebergs Arch Pharmacol 1996 Feb;353(3):250-60
|
alpha-((4-amino-1-phenylpyrazolo(3,4-d)pyrimidin-6-yl)thio)hexanamide
| 0
|
*Pyrazoles *Pyrimidines Receptors, Purinergic P1/antagonists & inhibitors.
|
J Med Chem 1996 Oct 11;39(21):4156-61
|
alpha-((4-(methylamino)-1-phenylpyrazolo(3,4-d)pyrimidin-6-yl)thio)hexanamide
| 0
|
*Pyrazoles *Pyrimidines Receptors, Purinergic P1/antagonists & inhibitors.
|
J Med Chem 1996 Oct 11;39(21):4156-61
|
8-butylaminoadenosine
| 65456-84-0
|
Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists.
|
J Pharmacol Exp Ther 1996 Dec;279(3):1439-46
|
8-cyclohexylcaffeine
| 0
|
Caffeine/*analogs & derivatives Receptors, Purinergic P1/antagonists & inhibitors.
|
Pharmacol Toxicol 1997 Jun;80(6):295-300
|
N6-(4-(((4-((((2-((((isothiocyanatophenyl)amino)thiocarbonyl)amino)ethyl)amino)carbonyl)methyl)anilino)carbonyl)methyl)phenyl)adenosine
| 0
|
Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists.
|
Mol Pharmacol 1997 Sep;52(3):491-8
|
| FSPTP pyrimidine
| 0
|
*Pyrimidines *Triazoles Receptors, Purinergic P1/antagonists & inhibitors.
|
Circulation 1998 Aug 18;98(7):711-8
|
N-(3-(2-pyridinyl)isoquinolin-1-yl)benzamidine
| 0
|
*Benzamidines *Isoquinolines Ligands Receptors, Purinergic P1/antagonists & inhibitors.
|
J Med Chem 1998 Oct 8;41(21):3987-93
|
| VUF 8504
| 0
|
*Isoquinolines *Pyridines Ligands Receptors, Purinergic P1/antagonists & inhibitors.
|
J Med Chem 1998 Oct 8;41(21):3994-4000
|
XH-14
| 0
|
*Benzofurans Receptors, Purinergic P1/antagonists & inhibitors.
|
Bioorg Med Chem 1998 Sep;6(9):1517-24
|
propyl 1-ethyl-8-oxo-3-phenyl-5,6,7,8-tetrahydro-7-thiaisoquinoline-4-carboxylate
| 0
|
*Bicyclo Compounds, Heterocyclic Receptors, Purinergic P1/antagonists & inhibitors.
|
J Med Chem 1999 Feb 25;42(4):706-21
|
4-amino-6-benzylamino-1,2-dihydro-2-phenyl-1,2,4-triazolo(4,3-a)-quinoxalin-1-one
| 0
|
*Quinoxalines *Triazoles Receptors, Purinergic P1/antagonists & inhibitors.
|
Arch Pharm (Weinheim) 1999 Feb;332(2):39-41
|
2,4-diethyl-1-methyl-3-(ethylsulfanylcarbonyl)-5-ethyloxycarbonyl-6-phenylpyridinium
| 0
|
*Pyridinium Compounds Receptors, Purinergic P1/antagonists & inhibitors.
|
J Med Chem 1999 Oct 7;42(20):4232-8
|
2-((phenylisopropyl)amino)adenosine
| 0
|
Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists.
|
Nucleosides Nucleotides 1999 Oct;18(10):2175-91
|
2-((1-phenylpropyl)amino)adenosine
| 0
|
Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists.
|
Nucleosides Nucleotides 1999 Oct;18(10):2175-91
|
| MRS 1204
| 0
|
Receptors, Purinergic P1/antagonists & inhibitors *Xanthines.
|
J Med Chem 2000 Mar 23;43(6):1165-72
|
| MRS 1595
| 0
|
Receptors, Purinergic P1/antagonists & inhibitors *Xanthines.
|
J Med Chem 2000 Mar 23;43(6):1165-72
|
N(6)-benzyl-5'-N-ethylcarboxamidoadenosine
| 0
|
Receptors, Purinergic P1/agonists Adenosine/*analogs & derivatives.
|
Eur J Pharmacol 2000 Apr 21;395(1):47-50
|
| MRS 1740
| 0
|
Receptors, Purinergic P1/antagonists & inhibitors Adenosine/*analogs & derivatives Thiourea/*analogs & derivatives.
|
J Biol Chem 2000 Sep 29;275(39):30272-9
|
| MRS 1741
| 0
|
Receptors, Purinergic P1/antagonists & inhibitors Adenosine/*analogs & derivatives Thiourea/*analogs & derivatives.
|
J Biol Chem 2000 Sep 29;275(39):30272-9
|
8-cyclopentyl-3-(3-(4-fluorosulfonylbenzamido)propyl)-1-propylxanthine
| 0
|
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