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Adenylate Cyclase

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Definition: An enzyme of the lyase class that catalyzes the formation of CYCLIC AMP and pyrophosphate from ATP. EC 4.6.1.1.     
Examples Adenylate Cyclase Toxin
Other names Adenyl Cyclase; Cyclase, Adenylyl; Cyclase, Adenylate; Cyclase, Adenyl; Adenylyl Cyclase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2',3'-O-(N-methylanthraniloyl)inosine 5'-triphosphate  0   Inosine Triphosphate/*analogs & derivatives Adenylate Cyclase/antagonists & inhibitors. Mol Pharmacol. 2011 Jul;80(1):87-96
NB001  0   Adenosine Triphosphate/*analogs & derivatives Adenylate Cyclase/antagonists & inhibitors. Sci Transl Med. 2011 Jan 12;3(65):65ra3
AC78C protein, Drosophila  EC 4.6.1.1   *Adenylate Cyclase *Drosophila Proteins. Eur J Neurosci. 2008 Nov;28(10):1956-66
Adk2 protein, S cerevisiae  EC 4.6.1.1   *Adenylate Cyclase *Saccharomyces cerevisiae Proteins. J Biol Chem 2005 May 13;280(19):18604-9
CAP1 protein, human  0   *Cytoskeletal Proteins *Cell Cycle Proteins Adenylate Cyclase Microfilament Proteins.
2',5'-dideoxy-2,5'-difluoroadenosine  0   Dideoxyadenosine/*analogs & derivatives Adenylate Cyclase/antagonists & inhibitors. J Med Chem 2004 Feb 26;47(5):1207-13
2',5'-dideoxy-2-fluoroadenosine  0   Dideoxyadenosine/*analogs & derivatives Adenylate Cyclase/antagonists & inhibitors. J Med Chem 2004 Feb 26;47(5):1207-13
rutabaga protein, Drosophila  EC 4.6.1.1   *Adenylate Cyclase *Drosophila Proteins. Science 2003 Dec 5;302(5651):1765-8
adenylyl cyclase 7  EC 4.6.1.1   *Adenylate Cyclase. J Biol Chem 2003 Feb 14;278(7):4552-60
ACY-1 protein, C elegans  EC 4.6.1.1   *Adenylate Cyclase *Caenorhabditis elegans Proteins. Genetics 2002 May;161(1):133-42
Rv1264 protein, Mycobacterium tuberculosis  EC 4.6.1.1   *Adenylate Cyclase *Bacterial Proteins. J Biol Chem 2002 May 3;277(18):15271-6
PsiP protein, Zea mays  EC 4.6.1.1   *Adenylate Cyclase *Plant Proteins Second Messenger Systems. Proc Natl Acad Sci U S A 2001 Aug 28;98(18):10481-6
CAP1 protein, Candida albicans  0   *Fungal Proteins *Cell Cycle Proteins Adenylate Cyclase. J Bacteriol 2001 May;183(10):3211-23
adenylate cyclase 3  EC 4.6.1.1   *Adenylate Cyclase. Nature 2001 Feb 22;409(6823):1051-5
adenylyl cyclase type V  EC 4.6.1.1   *Adenylate Cyclase. Eur J Biochem 2001 Jan;268(1):105-10
adenylate cyclase 9  EC 4.6.1.1   *Adenylate Cyclase. J Neurochem. 2000 Oct;75(4):1358-67
adenylyl cyclase 4  EC 4.6.1.1   *Adenylate Cyclase. Invest Ophthalmol Vis Sci 2000 Apr;41(5):998-1005
adenylyl cyclase 6  EC 4.6.1.1   *Adenylate Cyclase. Mol Pharmacol 1999 Sep;56(3):644-50
ACB protein, Dictyostelium  EC 4.6.1.1   *Adenylate Cyclase *Protozoan Proteins Adenylate Cyclase. Dev Biol 1999 Aug 1;212(1):182-90
adenylyl cyclase 8  EC 4.6.1.1   *Adenylate Cyclase. J Biol Chem 1999 Mar 19;274(12):8012-21
adenylyl cyclase 1  EC 4.6.1.1   *Adenylate Cyclase. Brain Res Mol Brain Res 1997 May;45(2):325-30
ACG protein, Dictyostelium discoideum  EC 4.6.1.1   *Adenylate Cyclase *Protozoan Proteins. J Biol Chem 1996 Sep 27;271(39):23623-5
adenylyl cyclase 2  EC 4.6.1.1   *Adenylate Cyclase. J Biol Chem 1996 Jul 26;271(30):17597-600
7b-deacetyl-7b-(gamma-(morpholino)butyryl)forskolin  0   Forskolin/*analogs & derivatives Adenylate Cyclase/agonists. Brain Res 1995 Nov 27;700(1-2):59-69
2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide  163042-96-4   Adenosine/*analogs & derivatives Adenylate Cyclase/antagonists & inhibitors Receptors, Purinergic P1/agonists. J Med Chem 1994 Oct 14;37(21):3614-21
8-hydroxy-2-(N-n-propyl-N-(3'-iodo-2'-propenyl)amino)tetralin  159559-70-3   *Tetrahydronaphthalenes Adenylate Cyclase/antagonists & inhibitors Receptors, Serotonin. J Med Chem 1993;36(21):3161-5
neuropeptide Y (17-36)  0   *Neuropeptide Y *Peptide Fragments Adenylate Cyclase/antagonists & inhibitors. J Biol Chem 1992 Mar 5;267(7):4680-5
5'-(4-bromomethylbenzoyl)adenosine  97143-48-1   Adenosine/*analogs & derivatives Adenylate Cyclase/antagonists & inhibitors. Biochem Int 1985;10(5):743
7,8-dioxo-N,N-didesmethylchlorpromazine  95574-31-5   Chlorpromazine/*analogs & derivatives Adenylate Cyclase/antagonists & inhibitors. Arch Int Pharmacodyn Ther 1985;273(2):202
7,8-dihydroxy-N,N-didesmethylchlorpromazine  95574-30-4   Chlorpromazine/*analogs & derivatives Adenylate Cyclase/antagonists & inhibitors. Arch Int Pharmacodyn Ther 1985;273(2):202
anthrax toxin  0   *Antigens, Bacterial *Bacterial Toxins Adenylate Cyclase Metalloendopeptidases Anthrax Vaccines. Pharmacol Ther 1981;12(3):501
9-(tetrahydro-2-furyl)-adenine  17318-31-9 9-(tetrahydro-2-furanyl)-9H-purin-6-amine  Adenine/*analogs & derivatives Adenylate Cyclase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors
Exp Cell Res 1979;124(1):205; Thromb Res 13(6):1089;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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