encyclopedia of medical concepts
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Thiourea

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Definition: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.  a thyroid antag   
Pharmacological Action Indicators and Reagents
Examples beta-Aminoethyl Isothiourea; Burimamide; Dimaprit; Guanylthiourea; Isothiuronium; Methallibure; Metiamide; Noxythiolin; Phenylthiourea
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N,N-dibenzyl-N'-(furan-2-carbonyl)thiourea  0   *Furans Thiourea/*analogs & derivatives. Acta Crystallogr C. 2012 Jan;68(Pt 1):o19-22
SPA0355  0   *Benzoxazines Thiourea/*analogs & derivatives. Br J Pharmacol. 2011 Sep;164(2b):794-806.
4,4'-bis(3-(4-trifluoromethylphenyl)thiourea)diphenyl sulfide  0   *Sulfides Thiourea/*analogs & derivatives. Analyst. 2011 Dec 21;136(24):5151-6.
1-(2-(1-azacyclooctanyl)-5-(trifluoromethyl))phenyl-3-nicotinoylthiourea  0   *Azocines Thiourea/*analogs & derivatives. PLoS One. 2011;6(8):e23246.
(3-(3-bromophenyl)-1-phenylpyrazol-4-yl)methyl carbamimidothioate  0   *Pyrazoles Thiourea/*analogs & derivatives. Mol Cancer Ther. 2011 Sep;10(9):1740-50.
(10-methyl-9-anthryl)methyl imidothiocarbamate  0   *Anthracenes Thiourea/*analogs & derivatives. Neoplasia. 2011 Jul;13(7):611-9.
1-(4-chloro-2,5-dimethoxyphenyl)-3-(3-propoxypropyl)thiourea  0   Thiourea/*analogs & derivatives. Eur J Med Chem. 2011 Feb;46(2):447-67
5-(2-chlorophenyl)-N-(2-(2nitrobenzoyl)hydrazinecarbonothioyl) furan-2-carboxamide  0   *Furans *Thiourea. Ecotoxicol Environ Saf. 2011 Mar;74(3);445-50
RRD 251  0   Thiourea/*analogs & derivatives. Cancer Res 2008 May 15;68(10):3810-8
1-(2-benzyl-1,3-dioxoisoindolin-5-yl)-3-(1-phenylethyl)thiourea  0   *Phthalimides Thiourea/*analogs & derivatives. Photochem Photobiol Sci 2010 Oct 28;9(10):1385-90
ICT 2552  0   *Oligopeptides Thiourea/*analogs & derivatives. Cancer Res 2010 Sep 1;70(17):6902-12
MitoBloCK-1  0   *Hydrazones Thiourea/*analogs & derivatives. Proc Natl Acad Sci U S A 2010 May 25;107(21):9578-83
4,4'-bis-(3-(4-nitrophenyl) thiourea) diphenyl methane  0   Thiourea/*analogs & derivatives. Anal Chim Acta. 2010 Mar 17;663(1):77-84
4,4'-bis-(3-(4-nitrophenyl) thiourea) diphenyl ether  0   *Phenyl Ethers Thiourea/*analogs & derivatives. Anal Chim Acta. 2010 Mar 17;663(1):77-84
4-chlorobenzyl carbamimidothioate  0   Thiourea/*analogs & derivatives. J Bacteriol 2010 Mar;192(6):1671-84
(4-(carbamimidoylsulfanylmethyl)-2,5-dimethylphenyl)methylsulfanylmethanimidamide  0   Thiourea/*analogs & derivatives. PLoS Negl Trop Dis 2009;3(1):e356
alpha-2-methyl-1-nitroisothiourea  0   Thiourea/*analogs & derivatives. J Phys Chem B. 2009 Sep 24;113(38):12648-54
N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea  0   *Isothiocyanates Thiourea/*analogs & derivatives. Biochem Biophys Res Commun 2009 Jul 10;384(4):512-8
3-allyl-1,1-dibenzyl-2-ethylisothiourea  0   *Allyl Compounds Thiourea/*analogs & derivatives. J Med Chem 2009 Apr 9;52(7):1845-52
N-(2,2-diphenylacetyl)-N'-(naphthalen-1yl)-thiourea  0   *Naphthalenes Thiourea/*analogs & derivatives. Spectrochim Acta A Mol Biomol Spectrosc. 2009 Apr;72(3):561-71
CR 3294  0   *Amidines Thiourea/*analogs & derivatives Nitric Oxide Synthase Type II/antagonists & inhibitors. Autophagy 2008 Nov 16;4(8):1042-53
1-((2-methoxy-phenyl)-(2-methoxy-phenylimino)methyl)-3-phenyl-thiourea  0   Thiourea/*analogs & derivatives. Bioorg Med Chem Lett 2008 Mar 15;18(6):2172-8
2-ethyl-2-thiopseudourea  0   Thiourea/*analogs & derivatives. Am J Physiol Lung Cell Mol Physiol 2008 Mar;294(3):L582-91
1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(1H-tetrazol-5-yl)phenyl)thiourea  0   *Tetrazoles Thiourea/*analogs & derivatives. Mol Pharmacol 2007 Oct;72(4):1033-44
(4-sulfamoylphenylethyl)thioureido fluorescein  0   *Fluoresceins Thiourea/*analogs & derivatives. J Am Chem Soc 2006 Jun 28;128(25):8329-35
N,N'-bis-(2-(cyano)ethoxycarbonyl)-2-methyl-2-thiopseudourea  0   Thiourea/*analogs & derivatives. Nucleosides Nucleotides Nucleic Acids 2007;26(2):149-59
N-(4-tert-butylbenzyl)-N'-(4-hydroxy-2-bromo-3-iodo-5-methoxybenzyl)thiourea  0   Thiourea/*analogs & derivatives TRPV Cation Channels/antagonists & inhibitors. Bioorg Med Chem Lett 2007 Jan 1;17(1):214-9
N-(3-(tert-butylcarbonyloxy)-2-(3,4-dimethylbenzyl)propyl)-N'-(4-hydroxy-2,3-diiodo-5-methoxybenzyl)thiourea  0   Thiourea/*analogs & derivatives TRPV Cation Channels/antagonists & inhibitors. Bioorg Med Chem Lett 2007 Jan 1;17(1):214-9
N-4-nitrobenzene-N'-1'-anthraquinone-thiourea  0   *Anthraquinones Thiourea/*analogs & derivatives. Spectrochim Acta A Mol Biomol Spectrosc. 2006 Nov;65(3-4):633-7
S-(2-guanidylethyl)isothiourea  0   *Guanidines Thiourea/*analogs & derivatives Receptors, Histamine. Radiat Res 1957 Jul;7(1):22-34
N-cyclopropyl-2-(6-(3,5-dimethylphenyl)thieno(3,2-d)pyrimidin-4-yl)hydrazine carbothioamide  0   *Thiophenes Thiourea/*analogs & derivatives. Clin Cancer Res 2006 Jun 15;12(12):3831-42
SNJ 1715  0   Thiourea/*analogs & derivatives Calpain/antagonists & inhibitors. J Med Chem 2006 Jun 29;49(13):3926-32
CGK 733  0   *Benzeneacetamides Thiourea/*analogs & derivatives. Nat Chem Biol 2006 Jul;2(7):369-74
N-benzamidothiourea  0   Thiourea/*analogs & derivatives. Org Biomol Chem. 2006 Feb 21;4(4):624-30
N-n-undecyl-N'-(4-aminobenzenesulfonic acid)thiourea  0   *Sulfanilic Acids Thiourea/*analogs & derivatives. J Sep Sci 2004 Sep;27(13):1115-20
N-n-hexyl-N'-(4-aminobenzenesulfonic acid)thiourea  0   *Sulfanilic Acids Thiourea/*analogs & derivatives. J Sep Sci 2004 Sep;27(13):1115-20
N-(4-((6,7-dimethoxy-4-quinolyl)oxy)phenyl)-N'-(2-methylbenzoyl)thiourea  0   *Quinolines Thiourea/*analogs & derivatives Receptors, Platelet-Derived Growth Factor/antagonists & inhibitors. J Med Chem 2006 Apr 6;49(7):2186-92
1-(3-(1H-imidazol-1-yl)propyl)-3-(3,4,5-trimethoxyphenyl)thiourea  0   *Imidazoles Thiourea/*analogs & derivatives. J Med Chem 2006 Jan 26;49(2):664-77
thioureido N-acetyllactosamine  0   *Amino Sugars Thiourea/*analogs & derivatives. Bioorg Med Chem. 2006 Feb 15;14(4):1215-20
(((4-(ethoxycarbonyl)phenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione  0   *Chromans Thiourea/*analogs & derivatives. Invest New Drugs 2005 Oct;23(5):417-28
N-(4-t-butylbenzyl)-N'-(4-(methylsulfonylamino)benzyl)thiourea  0   *Sulfonamides Thiourea/*analogs & derivatives. Bioorg Med Chem Lett 2005 Sep 15;15(18):4136-42
salubrinal  0   *Cinnamates Thiourea/*analogs & derivatives. Science 2005 Feb 11;307(5711):935-9
N-(3-acyloxy-2-benzylpropyl)-N'-(4-(methylsulfonylamino)benzyl)thiourea  0   *Benzyl Compounds Thiourea/*analogs & derivatives. Bioorg Med Chem. 2004 Jul 1;12(13):3411-20
6-O-tert-butyldimethylsilyl-2,3-methyl beta-cyclodextrin 2-2' thioureido dimer  0   *Cyclodextrins Thiourea/*analogs & derivatives. Chirality 2004 Oct;16(8):526-33
YH3945  0   Thiourea/*analogs & derivatives. Rapid Commun Mass Spectrom 2004;18(17):1901-10
N-phenyl-N'-(3,5-dimethylpyrazol-4-yl)thiourea  0   *Pyrazoles Thiourea/*analogs & derivatives. Eur J Drug Metab Pharmacokinet 2003 Oct-Dec;28(4):273-8
N-(N'-phenethylthiocarbamoyl)sphingosine  0   Sphingosine/*analogs & derivatives Thiourea/*analogs & derivatives. J Pharmacol Exp Ther 2004 May;309(2):452-61
N-(N'-phenethylthiocarbamoyl)sphinganine  0   Sphingosine/*analogs & derivatives Thiourea/*analogs & derivatives. J Pharmacol Exp Ther 2004 May;309(2):452-61
1-((5-(2-(5-chloro-o-anisamido)ethyl)-beta-methoxyethoxyphenyl)sulfonyl)-3-methylthiourea, sodium salt  0   Thiourea/*analogs & derivatives. J Pharmacol Exp Ther. 2004 Apr;309(1):182-92
((1-aza-4-methyl-6-(1,2,2,4-tetramethyl(1,2-dihydroquinolyl))hexa-1,3,5-trienyl)amino)aminomethane-1-thione  0   *Benzopyrans Thiourea/*analogs & derivatives. J Med Chem 2004 Feb 12;47(4):1008-17
ethyl 4-((N-(2,2,4,4-tetramethylchroman-6-yl)thiocarbamoyl)amino)benzoate  0   *Benzopyrans Thiourea/*analogs & derivatives. J Med Chem 2004 Feb 12;47(4):1008-17
N-(4-chlorobenzyl) -N'-(4-hydroxy-3-iodo-5-methoxybenzyl)thiourea  0   Thiourea/*analogs & derivatives. Mol Pharmacol 2004 Feb;65(2);282-91
CFI02  0   Thiourea/*analogs & derivatives. J Virol 2004 Feb;78(3);1289-300
N,N'-(4-tolyl)thiourea  0   *Toluidines Thiourea/*analogs & derivatives. Anal Sci 2003 Jul;19(7):1087-8
N,N'-(3-tolyl)thiourea  0   *Toluidines Thiourea/*analogs & derivatives. Anal Sci 2003 Jul;19(7):1087-8
(1-phenyl-3-(3-methoxy-2-propoxy-5-(4-(3,4,5-trimethoxy-phenyl)-1,3-d lane-2-yl)phenyl)thiourea)  0   Thiourea/*analogs & derivatives. J Ocul Pharmacol Ther. 2003 Jun;19(3):247-53
N-phenyl-N'-2-pyridylthiourea  886-60-2   *Pyridines Thiourea/*analogs & derivatives. Genetika 2003 Jul;39(7):927-38
N-allyl-N'-2-pyridylthiourea  880-14-8   *Pyridines Thiourea/*analogs & derivatives. Genetika 2003 Jul;39(7):927-38
N-(4-tert-butylbenzyl)-N'-(3-methoxy-4-(methylsulfonylamino)benzyl)thiourea  0   *Sulfonamides Thiourea/*analogs & derivatives. Mol Pharmacol 2003 Aug;64(2):325-33
N-(2-(3,4-dimethylbenzyl)-3-(pivaloyloxy)propyl)-N'-(4-(methylsulfonylamino)benzyl)thiourea  0   *Sulfonamides Thiourea/*analogs & derivatives. Mol Pharmacol 2003 Aug;64(2):325-33
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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