Cholinesterase Reactivators (definition)

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Cholinesterase Reactivators

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Definition: Drugs used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates. They are an important component of therapy in agricultural, industrial, and military poisonings by organophosphates and sulfonates.

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Other names Organothiophosphate Insecticide Antagonists; Organophosphate Insecticide Antagonists; Insecticides, Organothiophosphate, Antagonists; Insecticides, Organophosphate, Antagonists; Insecticide Antagonists, Organothiophosphate; Insecticide Antagonists, Organophosphate; Antagonists, Organothiophosphate Insecticide; Reactivators, Cholinesterase; Antagonists, Organophosphate Insecticide

Substances having this pharmacologic action: HI 6; pralidoxime; diacetylmonoxime; Trimedoxime; Obidoxime Chloride; HLo 7

Substance	Categories	Source
isonitrosoacetone	*Oximes Cholinesterase Reactivators.	Chem Biol Interact. 2011 Nov 15;194(2-3):91-6.
2-(hydroxyimino)-N,N-dimethyl-N'-propylacetimidamide	*Amidines Cholinesterase Reactivators.	J Med Chem 2011 May 12;54(9):3319-30
N'-ethyl-2-(hydroxyimino)-N,N-dimethylacetimidamide	*Amidines Cholinesterase Reactivators.	J Med Chem 2011 May 12;54(9):3319-30

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor

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