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Pralidoxime Compounds

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Definition: Various salts of a quaternary ammonium oxime that reconstitute inactivated acetylcholinesterase, especially at the neuromuscular junction, and may cause neuromuscular blockade. They are used as antidotes to organophosphorus poisoning as chlorides, iodides, methanesulfonates (mesylates), or other salts.  DF: PRALIDOXIME CPDS    Other names Pyridine Aldoxime Methyl Compounds; 2-PAM Compounds; Compounds, Pralidoxime; Compounds, 2-PAM; 2 PAM Compounds
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
8-(4-(4-(-(hydroxyimino)methyl)-1-pyridiniumyl)butyl)-3-((3-hydroxy-2-phenylpropanoyl)oxy)-8-methyl-8-azoniabicyclo(3.2.1)octane  0   *Atropine Derivatives *Pralidoxime Compounds. Acta Biochim Pol 2011;58(2):193-8
duodote  0   *Atropine *Pralidoxime Compounds Drug Combinations. FDA Consum 2006 Nov-Dec;40(6):6DUODOTE; ATNAA
pralidoxime  6735-59-7   *Pralidoxime Compounds.
Pharma Action Antidotes ; Cholinesterase Reactivators 		Biochm Pharmacol 27(18):2229;1978; Br J Pharmacol 44(2):368P;1972; J Immunol Methods 1980;35(1-2):157; J Neurosci Res 2:299;1976; Toxicol Appl Pharmacol 40:109;1977PRALIDOXIME CHLORIDE; PROTOPAM CHLORIDE
HS 3  25487-36-9 2-((hydroxyimino)methyl)-1-(((4-((hydroxyimino)methyl)pyridinio)methoxy)methyl)pyridinium, dichloride  *Pralidoxime Compounds. Arch Toxicol 36(1):71;1976
1-methyl-1,6-dihydropyridine-2-carbaldoxime  57619-23-5   *Pralidoxime Compounds. J Med Chem 19(1):102-13;1976; Toxicol Appl Pharmacol 47(2):305;1979
HS 6  22625-23-6 1-(((3-(aminocarbonyl)pyridinio)methoxy)methyl)-2-((hydroxyimino)methyl)pyridinium dichloride  *Pralidoxime Compounds. Arch Toxicol 36(1):71;1976; Biochem Pharmacol 21(8):1187;1972; Can J Physiol Pharmacol 56(5):857;1978; Eur J Pharmacol 53(2):135;1979
3-MPAM-ES  15129-49-4   *Pralidoxime Compounds. Comp Biochem Physiol (B) 42(3):429;1972
atropine, pralidoxime iodide, trichlorofon drug combination  8072-45-5   *Atropine *Pralidoxime Compounds *Trichlorfon Drug Combinations. Arch Exp Veterinaermed 25(5):831;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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