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Ligases
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Definition
: A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.
Examples
Carbon-Carbon Ligases
;
Carbon-Nitrogen Ligases
;
Carbon-Oxygen Ligases
;
Carbon-Sulfur Ligases
;
Polynucleotide Ligases
;
Ubiquitin-Protein Ligase Complexes
Other names
Synthetases; Synthetase
Substance
CAS Registry & name
Categories
Source
Drugs
*
MMS21 protein, Arabidopsis
EC 6.3.2.-
*Ligases
*Arabidopsis Proteins.
Plant Signal Behav. 2010 Jan;5(1):53-5
FadD26 protein, Mycobacterium tuberculosis
EC 6.5.-
*Bacterial Proteins
*Ligases.
FEBS J. 2010 Jun;277(12):2715-25
FadD29 protein, Mycobacterium tuberculosis
EC 6.5.-
*Bacterial Proteins
*Ligases.
FEBS J. 2010 Jun;277(12):2715-25
FadD22 protein, Mycobacterium tuberculosis
EC 6.5.-
*Ligases
*Bacterial Proteins.
FEBS J. 2010 Jun;277(12):2715-25
MccB protein, E coli
EC 6.-
*Ligases
*Escherichia coli Proteins.
EMBO J 2009 Jul 8;28(13):1953-64
gamma-
glutamylputrescine synthetase, E coli
EC 6.3.1.11
*Ligases
*Escherichia coli Proteins.
J Biol Chem 2008 Jul 18;283(29):19981-90
CRSH protein, Arabidopsis
EC 6.-
*Ligases
*Arabidopsis Proteins.
Plant Cell Physiol 2008 Feb;49(2):135-41
salicyl-
AMP ligase, Mycobacterium tuberculosis
EC 6.-
*Ligases.
J Med Chem 2007 Nov 29;50(24):6080-94
GH3.5 protein, Arabidopsis
EC 6.-
*Ligases
*Arabidopsis Proteins.
Plant Physiol 2007 Oct;145(2):450-64
GH3.9 protein, Arabidopsis
EC 6.-
*Ligases
*Arabidopsis Proteins.
Planta 2007 Jun;226(1):21-34
curcuminoid synthase, Curcuma longa
EC 6.-
*Ligases.
Phytochemistry 2006 Sep;67(18):2017-29
NSMCE2 protein, human
EC 6.3.2.-
*Ligases
DNA Repair.
Mol Cell Biol 2005 Aug;25(16):7021-32
SIZ1 protein, Arabidopsis
EC 6.3.2.-
*Ligases
*Arabidopsis Proteins.
Proc Natl Acad Sci U S A 2005 May 24;102(21):7760-5
uridine 5'-
diphospho-
N-
acetylmuramoyl-
L-
alanyl-
D-
glutamate:L-
lysine ligase
EC 6.3.2.7
*Ligases.
Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):359-61
lplA protein, E coli
0
*Ligases
*Escherichia coli Proteins.
RCE1 protein, Arabidopsis
EC 6.-
*Ligases.
Proc Natl Acad Sci U S A 1999 Dec 21;96(26):15342-7
HEY1 protein, human
0
*Cell Cycle Proteins
*Basic Helix-Loop-Helix Transcription Factors
Ligases.
Upl3 protein, Arabidopsis
EC 6.-
*Ligases
*Arabidopsis Proteins.
Plant J 2003 Sep;35(6):729-42
pyochelin synthetase, Pseudomonas aeruginosa
EC 6.-
*Ligases.
Biochemistry 2003 Sep 9;42(35):10514-27
sakura protein, rat
EC 6.-
*Ligases
Zinc Fingers.
J Neurochem 2003 Aug;86(3):749-62
momo protein, rat
EC 6.-
*Ligases
Zinc Fingers.
J Neurochem 2003 Aug;86(3):749-62
GIPN protein, rat
EC 6.-
*Ligases.
Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8270-5
PIASx protein, mouse
EC 6.-
*Ubiquitin-Protein Ligases
*Protein Inhibitors of Activated STAT
Ligases.
Biochem Biophys Res Commun 2003 Aug 15;308(1);139-47
p33(RUL) protein, human
EC 6.-
*Ligases.
J Biol Chem 2003 Jul 18;278(29):26851-61
Ube2v2 protein, rat
EC 6.3.2.-
*Ligases
*Nerve Tissue Proteins.
Brain Res Mol Brain Res. 2003 May 12;113(1-2):13-27
Ubc-
18 protein, C elegans
EC 6.3.2.-
*Ligases
*Caenorhabditis elegans Proteins.
Development 2003 Jul;130(14):3319-30
Cdt-
1 protein, C elegans
0
*Ligases
*Caenorhabditis elegans Proteins.
Nature 2003 Jun 19;423(6942):818-9
Cul-
4 protein, C elegans
EC 6.3.2.19
*Ligases
*Caenorhabditis elegans Proteins.
Nature 2003 Jun 19;423(6942):818-9
UBC19 protein, Arabidopsis
EC 6.-
*Ligases.
Plant Physiol 2002 Nov;130(3):1230-40
luciferin-
regenerating enzyme, insect
EC 6.-
*Ligases
*Insect Proteins.
Gene 2002 Jul 10;294(1-2):157-66
VanE protein, Enterococcus faecalis
EC 6.-
*Bacterial Proteins
*Ligases.
Antimicrob Agents Chemother 1999 Sep;43(9):2161-4
catecholamine-
beta-
alanyl ligase
EC 6.3.2.
*Ligases.
Insect Biochem Mol Biol 2002 Jun;32(6):617-25
HUB1 protein, S cerevisiae
EC 6.3.2.-
*Ligases
*Saccharomyces cerevisiae Proteins
Ubiquitin-Protein Ligase Complexes.
Science 2002 Mar 29;295(5564):2442-6
N-
acylhomoserine lactone synthase
EC 6.1.-
*Ligases.
FEMS Microbiol Lett 2002 Jan 10;206(2):201-7
MP48 protein, Trypanosoma brucei
EC 6.5.1.3
*Ligases
*Protozoan Proteins
RNA Editing.
Mol Cell Biol 2001 Jan;21(2):380-9
UBA4 protein, S cerevisiae
0
*Saccharomyces cerevisiae Proteins
Ligases.
J Biol Chem 2000 Mar 17;275(11):7462-5
Aos1 protein, Drosophila
EC 6.3.2.-
*Ligases
*Drosophila Proteins
Ubiquitin-Conjugating Enzymes
Ubiquitin-Activating Enzymes.
J Biol Chem 2000 Feb 11;275(6):4033-40
beta-
L-
malyl-
AMP ligase
EC 6.5.-
*Ligases.
Eur J Biochem 1999 Nov;265(3):1085-90
Hey1 protein, mouse
0
*Cell Cycle Proteins
Ligases.
Genes Dev 1999 Jun 15;13(12):1614-26
UBE2V2 protein, human
EC 6.3.2.19
*Ligases.
Nucleic Acids Res 1998 Sep 1;26(17):3908-14
lichenysin A synthetase
EC 6.-
*Ligases.
Biotechnol Prog 1997 Nov-Dec;13(6):757-61
RfaL protein, E coli
0
*Ligases
*Membrane Proteins
*Escherichia coli Proteins.
J Bacteriol 1992 Nov;174(22):7297-307
PCS60 protein, S cerevisiae
EC 6.-.-.-
*Ligases
*Membrane Proteins
*Saccharomyces cerevisiae Proteins.
Eur J Biochem 1996 Sep 1;240(2):468-76
lactylalanine synthetase
EC 6.3.2.-
*Ligases.
Biochemistry 1996 Aug 13;35(32):10464-71
guanosine pentaphosphate synthetase
EC 2.7.6.-
*Ligases.
J Bacteriol 1996 Jul;178(14):4281-8
pyridoxal phosphate biosynthetic protein, E coli
0
*Ligases
*Escherichia coli Proteins.
J Bacteriol 1996 Apr;178(8):2445-9
RHLI protein, Pseudomonas aeruginosa
EC 6.1.-
*Ligases
*Transcription Factors.
Mol Microbiol 1995 Jul;17(2):333-43
OutB protein, Bacillus subtilis
EC 6.3.5.1
*Bacterial Proteins
*Ligases
Spores, Bacterial.
J Gen Microbiol 1992 Jan 139 (Pt 1):31-7
6-
hydroxymellein synthetase
EC 6.-
*Acyltransferases
*Ligases
*Multienzyme Complexes
*Oxidoreductases.
FEBS Lett 1991;288(1-2):219
enterobactin synthetase
EC 6.-
*Ligases
*Multienzyme Complexes.
J Bacteriol 1990;172(11):6403
2,3-
dihydroxybenzoate-
AMP ligase, E coli
EC 6.5.-
*Ligases
*Escherichia coli Proteins.
Biochemistry 1989;28(17):6827
RNA 3'-
terminal phosphate cyclase
EC 6.5.-
*Ligases.
Nucleic Acid Res 1983;11(5):1405
guanosine 3',5'-
polyphosphate synthetases
EC 6.-
*Ligases.
J Bacteriol 1981;145(1):68
DNA synaptase
EC 6.-
*Ligases.
Proc Natl Acad Sci USA 1980;77(5):2390
6-
methylsalicylic acid synthetase
EC 6.-
*Acyltransferases
*Ligases
*Multienzyme Complexes
*Oxidoreductases.
Eur J Biochem 13(1):98;1970; Eur J Biochem 68(2):591;1976; Hoppe Seylers Z Physiol Chem 353(2):126;1972; Methods Enzymol 43:520;1975; Microenvironments and metabolic compartmentation QH 604.3 V816m:p283;1978
4-
(4'-
hydroxy-
3'-
methylbut-
2'-
enyl)-
L-
tryptophan synthetase
EC 6.-
*Ligases.
FEBS Lett 82(1):55;1977