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Ligases

More information in Books or onNLM PubMed
Definition: A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.     
Examples Carbon-Carbon Ligases; Carbon-Nitrogen Ligases; Carbon-Oxygen Ligases; Carbon-Sulfur Ligases; Polynucleotide Ligases; Ubiquitin-Protein Ligase Complexes 		Other names Synthetases; Synthetase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MMS21 protein, Arabidopsis  EC 6.3.2.-   *Ligases *Arabidopsis Proteins. Plant Signal Behav. 2010 Jan;5(1):53-5
FadD26 protein, Mycobacterium tuberculosis  EC 6.5.-   *Bacterial Proteins *Ligases. FEBS J. 2010 Jun;277(12):2715-25
FadD29 protein, Mycobacterium tuberculosis  EC 6.5.-   *Bacterial Proteins *Ligases. FEBS J. 2010 Jun;277(12):2715-25
FadD22 protein, Mycobacterium tuberculosis  EC 6.5.-   *Ligases *Bacterial Proteins. FEBS J. 2010 Jun;277(12):2715-25
MccB protein, E coli  EC 6.-   *Ligases *Escherichia coli Proteins. EMBO J 2009 Jul 8;28(13):1953-64
gamma-glutamylputrescine synthetase, E coli  EC 6.3.1.11   *Ligases *Escherichia coli Proteins. J Biol Chem 2008 Jul 18;283(29):19981-90
CRSH protein, Arabidopsis  EC 6.-   *Ligases *Arabidopsis Proteins. Plant Cell Physiol 2008 Feb;49(2):135-41
salicyl-AMP ligase, Mycobacterium tuberculosis  EC 6.-   *Ligases. J Med Chem 2007 Nov 29;50(24):6080-94
GH3.5 protein, Arabidopsis  EC 6.-   *Ligases *Arabidopsis Proteins. Plant Physiol 2007 Oct;145(2):450-64
GH3.9 protein, Arabidopsis  EC 6.-   *Ligases *Arabidopsis Proteins. Planta 2007 Jun;226(1):21-34
curcuminoid synthase, Curcuma longa  EC 6.-   *Ligases. Phytochemistry 2006 Sep;67(18):2017-29
NSMCE2 protein, human  EC 6.3.2.-   *Ligases DNA Repair. Mol Cell Biol 2005 Aug;25(16):7021-32
SIZ1 protein, Arabidopsis  EC 6.3.2.-   *Ligases *Arabidopsis Proteins. Proc Natl Acad Sci U S A 2005 May 24;102(21):7760-5
uridine 5'-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine ligase  EC 6.3.2.7   *Ligases. Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):359-61
lplA protein, E coli  0   *Ligases *Escherichia coli Proteins.
RCE1 protein, Arabidopsis  EC 6.-   *Ligases. Proc Natl Acad Sci U S A 1999 Dec 21;96(26):15342-7
HEY1 protein, human  0   *Cell Cycle Proteins *Basic Helix-Loop-Helix Transcription Factors Ligases.
Upl3 protein, Arabidopsis  EC 6.-   *Ligases *Arabidopsis Proteins. Plant J 2003 Sep;35(6):729-42
pyochelin synthetase, Pseudomonas aeruginosa  EC 6.-   *Ligases. Biochemistry 2003 Sep 9;42(35):10514-27
sakura protein, rat  EC 6.-   *Ligases Zinc Fingers. J Neurochem 2003 Aug;86(3):749-62
momo protein, rat  EC 6.-   *Ligases Zinc Fingers. J Neurochem 2003 Aug;86(3):749-62
GIPN protein, rat  EC 6.-   *Ligases. Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8270-5
PIASx protein, mouse  EC 6.-   *Ubiquitin-Protein Ligases *Protein Inhibitors of Activated STAT Ligases. Biochem Biophys Res Commun 2003 Aug 15;308(1);139-47
p33(RUL) protein, human  EC 6.-   *Ligases. J Biol Chem 2003 Jul 18;278(29):26851-61
Ube2v2 protein, rat  EC 6.3.2.-   *Ligases *Nerve Tissue Proteins. Brain Res Mol Brain Res. 2003 May 12;113(1-2):13-27
Ubc-18 protein, C elegans  EC 6.3.2.-   *Ligases *Caenorhabditis elegans Proteins. Development 2003 Jul;130(14):3319-30
Cdt-1 protein, C elegans  0   *Ligases *Caenorhabditis elegans Proteins. Nature 2003 Jun 19;423(6942):818-9
Cul-4 protein, C elegans  EC 6.3.2.19   *Ligases *Caenorhabditis elegans Proteins. Nature 2003 Jun 19;423(6942):818-9
UBC19 protein, Arabidopsis  EC 6.-   *Ligases. Plant Physiol 2002 Nov;130(3):1230-40
luciferin-regenerating enzyme, insect  EC 6.-   *Ligases *Insect Proteins. Gene 2002 Jul 10;294(1-2):157-66
VanE protein, Enterococcus faecalis  EC 6.-   *Bacterial Proteins *Ligases. Antimicrob Agents Chemother 1999 Sep;43(9):2161-4
catecholamine-beta-alanyl ligase  EC 6.3.2.   *Ligases. Insect Biochem Mol Biol 2002 Jun;32(6):617-25
HUB1 protein, S cerevisiae  EC 6.3.2.-   *Ligases *Saccharomyces cerevisiae Proteins Ubiquitin-Protein Ligase Complexes. Science 2002 Mar 29;295(5564):2442-6
N-acylhomoserine lactone synthase  EC 6.1.-   *Ligases. FEMS Microbiol Lett 2002 Jan 10;206(2):201-7
MP48 protein, Trypanosoma brucei  EC 6.5.1.3   *Ligases *Protozoan Proteins RNA Editing. Mol Cell Biol 2001 Jan;21(2):380-9
UBA4 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins Ligases. J Biol Chem 2000 Mar 17;275(11):7462-5
Aos1 protein, Drosophila  EC 6.3.2.-   *Ligases *Drosophila Proteins Ubiquitin-Conjugating Enzymes Ubiquitin-Activating Enzymes. J Biol Chem 2000 Feb 11;275(6):4033-40
beta-L-malyl-AMP ligase  EC 6.5.-   *Ligases. Eur J Biochem 1999 Nov;265(3):1085-90
Hey1 protein, mouse  0   *Cell Cycle Proteins Ligases. Genes Dev 1999 Jun 15;13(12):1614-26
UBE2V2 protein, human  EC 6.3.2.19   *Ligases. Nucleic Acids Res 1998 Sep 1;26(17):3908-14
lichenysin A synthetase  EC 6.-   *Ligases. Biotechnol Prog 1997 Nov-Dec;13(6):757-61
RfaL protein, E coli  0   *Ligases *Membrane Proteins *Escherichia coli Proteins. J Bacteriol 1992 Nov;174(22):7297-307
PCS60 protein, S cerevisiae  EC 6.-.-.-   *Ligases *Membrane Proteins *Saccharomyces cerevisiae Proteins. Eur J Biochem 1996 Sep 1;240(2):468-76
lactylalanine synthetase  EC 6.3.2.-   *Ligases. Biochemistry 1996 Aug 13;35(32):10464-71
guanosine pentaphosphate synthetase  EC 2.7.6.-   *Ligases. J Bacteriol 1996 Jul;178(14):4281-8
pyridoxal phosphate biosynthetic protein, E coli  0   *Ligases *Escherichia coli Proteins. J Bacteriol 1996 Apr;178(8):2445-9
RHLI protein, Pseudomonas aeruginosa  EC 6.1.-   *Ligases *Transcription Factors. Mol Microbiol 1995 Jul;17(2):333-43
OutB protein, Bacillus subtilis  EC 6.3.5.1   *Bacterial Proteins *Ligases Spores, Bacterial. J Gen Microbiol 1992 Jan 139 (Pt 1):31-7
6-hydroxymellein synthetase  EC 6.-   *Acyltransferases *Ligases *Multienzyme Complexes *Oxidoreductases. FEBS Lett 1991;288(1-2):219
enterobactin synthetase  EC 6.-   *Ligases *Multienzyme Complexes. J Bacteriol 1990;172(11):6403
2,3-dihydroxybenzoate-AMP ligase, E coli  EC 6.5.-   *Ligases *Escherichia coli Proteins. Biochemistry 1989;28(17):6827
RNA 3'-terminal phosphate cyclase  EC 6.5.-   *Ligases. Nucleic Acid Res 1983;11(5):1405
guanosine 3',5'-polyphosphate synthetases  EC 6.-   *Ligases. J Bacteriol 1981;145(1):68
DNA synaptase  EC 6.-   *Ligases. Proc Natl Acad Sci USA 1980;77(5):2390
6-methylsalicylic acid synthetase  EC 6.-   *Acyltransferases *Ligases *Multienzyme Complexes *Oxidoreductases. Eur J Biochem 13(1):98;1970; Eur J Biochem 68(2):591;1976; Hoppe Seylers Z Physiol Chem 353(2):126;1972; Methods Enzymol 43:520;1975; Microenvironments and metabolic compartmentation QH 604.3 V816m:p283;1978
4-(4'-hydroxy-3'-methylbut-2'-enyl)-L-tryptophan synthetase  EC 6.-   *Ligases. FEBS Lett 82(1):55;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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