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Carbon-Nitrogen Ligases
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Definition
: Enzymes that catalyze the joining of two molecules by the formation of a carbon-nitrogen bond. EC 6.3.
DF: C N LIGASES
Examples
Adenylosuccinate Synthase
;
Amide Synthases
;
Argininosuccinate Synthase
;
Carbamoyl-Phosphate Synthase (Ammonia)
;
Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor
;
Formate-Tetrahydrofolate Ligase
;
Peptide Synthases
Other names
Ligases, Carbon-
Nitrogen; Carbon Nitrogen Ligases
Substance
CAS Registry & name
Categories
Source
Drugs
*
phosphoribosylformylglycinamidine synthase, Drosophila
EC 6.3.5.3
*Carbon-Nitrogen Ligases.
Genetics 2011 Jun;188(2):359-67
DUG3 protein, S cerevisiae
EC 6.3.-
*Carbon-Nitrogen Ligases.
Genetics 2007 Mar;175(3):1137-51
GART protein, human
EC 6.3.4.13
*Carbon-Nitrogen Ligases
*Phosphoribosylglycinamide Formyltransferase.
carbapenam synthetase
EC 6.3.3.-
*Carbon-Nitrogen Ligases.
J Biol Chem 2003 Oct 17;278(42):40996-1002
Pub2 protein, S pombe
EC 6.3.2.-
*Carbon-Nitrogen Ligases
*Schizosaccharomyces pombe Proteins.
J Cell Sci 2002 May 1;115(Pt 9):1847-57
norcoclaurine synthase
EC 6.3.3.-
*Carbon-Nitrogen Ligases.
Planta 2001 Oct;213(6):898-906
Fae protein, Methylobacterium extorquens
EC 6.3.4.-
*Bacterial Proteins
*Carbon-Nitrogen Ligases.
J Bacteriol 2000 Dec;182(23):6645-50
selenomethionine glycinamide ribonucleotide synthetase
EC 6.3.4.-
*Carbon-Nitrogen Ligases.
Acta Crystallogr D Biol Crystallogr 1999 Feb;55(Pt 2):518-21
biotinyl-
AMP synthetase
EC 6.3.4.-
*Carbon-Nitrogen Ligases.
Mol Genet Metab 1998 Aug;64(4):250-5
Pub1 protein, S pombe
EC 6.3.-
*Carbon-Nitrogen Ligases
*Schizosaccharomyces pombe Proteins.
EMBO J 1996 Mar 15;15(6):1301-12
aminodeoxychorismate synthase
EC 6.3.5.8
*Carbon-Nitrogen Ligases.
Proc Natl Acad Sci USA 1990;87(23):9391
birA protein, E coli
EC 6.3.4.15
*Repressor Proteins
*Carbon-Nitrogen Ligases
*Escherichia coli Proteins.
J Biol Chem 1989;264(1):5
purine imidazole-
ring cyclase
EC 6.3.3.-
*Carbon-Nitrogen Ligases
DNA Repair.
Proc Natl Acad Sci USA 1985;82(3):633
biotin-
(acetyl-
CoA carboxylase)synthetase
EC 6.3.4.15
*Carbon-Nitrogen Ligases.
Eur J Biochem 1980;111(1):79
biotin-
(methylmalonyl-
CoA-
carboxyltransferase) synthetase
EC 6.3.4.9
*Carbon-Nitrogen Ligases.
J Biol Chem 1980;255(15):7397
carbamoyl-
phosphate synthetase (N-
acetylglutamate)
EC 6.3.4.-
*Carbon-Nitrogen Ligases.
Science 1980;208(4441):291
holocarboxylase synthetases
EC 6.3.4.-
*Carbon-Nitrogen Ligases.
J Pediatr 1980;96(5):845; Life Sci 19:1377;1976; Proc Soc Exp Biol Med 145(2):565;1974
urea carboxylase (hydrolyzing)
EC 6.3.4.6
*Carbon-Nitrogen Ligases.
Anal Biochem 72:468;1976; Biochem Biophys Res Commun 49(1):45;1972; Biochim Biophys Acta 438(2):574;1976; J Biol Chem 247(13):4107;1972; J Biol Chem 248(17):6203;1973; Mol Gen Genet 166(3):251;1978
5-
phosphoribosylamine synthetase
EC 6.3.4.7
*Carbon-Nitrogen Ligases.
Proc Natl Acad Sci USA 73(7):2458;1976
5'-
phosphoribosylimidazoleacetate synthetase
EC 6.3.4.8
*Carbon-Nitrogen Ligases.
J Clin Invest 58(1):137;1976
phosphoribosylamine-
glycine ligase
EC 6.3.4.13
*Carbon-Nitrogen Ligases.
Ciba Found Symp 48:23;1977; J Biol Chem 248(6):1970;1973; Methods Enzymol 51:179;1978
phosphoribosylaminoimidazole synthase
EC 6.3.3.1
*Carbon-Nitrogen Ligases.
Somatic Cell Genet 5(2):203;1979
5,10-
methenyltetrahydrofolate synthetase
EC 6.3.3.2 5-
formyltetrahydrofolate cyclo-
ligase (ADP-
forming)
*Carbon-Nitrogen Ligases.
J Histochem Cytochem 25(5):349;1977
GMP synthase
EC 6.3.4.1
*Carbon-Nitrogen Ligases.
J Biol Chem 250(18):7372;1975; J Biol Chem 250(7):2609;1975; J Biol Chem 252(15):5431;1977; Methods Enzymol 51:213;1978; Methods Enzymol 51:219;1978
gamma-
glutamylmethylamide synthetase
EC 6.3.4.12
*Carbon-Nitrogen Ligases.
Biochem Biophys Res Commun 76(2):609;1977; J Biol Chem 244(15):4136;1969
dethiobiotin synthetase
EC 6.3.3.3
*Carbon-Nitrogen Ligases.
Adv Appl Microbiol 22:145;1977; J Bacteriol 123(1):248;1975; J Bacteriol 134(3):1002;1978; J Biol Chem 244(20):5503;1969; Methods Enzymol 62:326;1979; Methods Enzymol 62:348;1979
CTP synthetase
EC 6.3.4.2
*Carbon-Nitrogen Ligases.
Adv Enzyme Regul 16:3;1977; J Bacteriol 137(3):1073;1979; J Biol Chem 242:4715;1969; J Biol Chem 245:2529;1970; J Neurochem 22(6):1027;1974; J Neurosci Res 2(5/6):413;1977; Methods Enzymol 51:79;1978; Nature 271(5640):71;1978; Ukr Biokhem Zh 49(3):76;1977
canavaninosuccinate synthetase
EC 6.3.4.-
*Carbon-Nitrogen Ligases.
Clin Chem 21(12):1777;1975
biotin carboxylase
EC 6.3.4.14
*Carbon-Nitrogen Ligases.
J Am Chem Soc 98(12):3741;1976
N-
(5-
amino-
1-
ribosyl-
4-
imidazolylcarbonyl)-
L-
aspartic acid 5'-
phosphate synthetase
EC 6.3.4.-
*Carbon-Nitrogen Ligases.
Methods Enzymol 51:186;1978