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Carbon-Nitrogen Ligases

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Definition: Enzymes that catalyze the joining of two molecules by the formation of a carbon-nitrogen bond. EC 6.3.  DF: C N LIGASES   
Examples Adenylosuccinate Synthase; Amide Synthases; Argininosuccinate Synthase; Carbamoyl-Phosphate Synthase (Ammonia); Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor; Formate-Tetrahydrofolate Ligase; Peptide Synthases 		Other names Ligases, Carbon-Nitrogen; Carbon Nitrogen Ligases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
phosphoribosylformylglycinamidine synthase, Drosophila  EC 6.3.5.3   *Carbon-Nitrogen Ligases. Genetics 2011 Jun;188(2):359-67
DUG3 protein, S cerevisiae  EC 6.3.-   *Carbon-Nitrogen Ligases. Genetics 2007 Mar;175(3):1137-51
GART protein, human  EC 6.3.4.13   *Carbon-Nitrogen Ligases *Phosphoribosylglycinamide Formyltransferase.
carbapenam synthetase  EC 6.3.3.-   *Carbon-Nitrogen Ligases. J Biol Chem 2003 Oct 17;278(42):40996-1002
Pub2 protein, S pombe  EC 6.3.2.-   *Carbon-Nitrogen Ligases *Schizosaccharomyces pombe Proteins. J Cell Sci 2002 May 1;115(Pt 9):1847-57
norcoclaurine synthase  EC 6.3.3.-   *Carbon-Nitrogen Ligases. Planta 2001 Oct;213(6):898-906
Fae protein, Methylobacterium extorquens  EC 6.3.4.-   *Bacterial Proteins *Carbon-Nitrogen Ligases. J Bacteriol 2000 Dec;182(23):6645-50
selenomethionine glycinamide ribonucleotide synthetase  EC 6.3.4.-   *Carbon-Nitrogen Ligases. Acta Crystallogr D Biol Crystallogr 1999 Feb;55(Pt 2):518-21
biotinyl-AMP synthetase  EC 6.3.4.-   *Carbon-Nitrogen Ligases. Mol Genet Metab 1998 Aug;64(4):250-5
Pub1 protein, S pombe  EC 6.3.-   *Carbon-Nitrogen Ligases *Schizosaccharomyces pombe Proteins. EMBO J 1996 Mar 15;15(6):1301-12
aminodeoxychorismate synthase  EC 6.3.5.8   *Carbon-Nitrogen Ligases. Proc Natl Acad Sci USA 1990;87(23):9391
birA protein, E coli  EC 6.3.4.15   *Repressor Proteins *Carbon-Nitrogen Ligases *Escherichia coli Proteins. J Biol Chem 1989;264(1):5
purine imidazole-ring cyclase  EC 6.3.3.-   *Carbon-Nitrogen Ligases DNA Repair. Proc Natl Acad Sci USA 1985;82(3):633
biotin-(acetyl-CoA carboxylase)synthetase  EC 6.3.4.15   *Carbon-Nitrogen Ligases. Eur J Biochem 1980;111(1):79
biotin-(methylmalonyl-CoA-carboxyltransferase) synthetase  EC 6.3.4.9   *Carbon-Nitrogen Ligases. J Biol Chem 1980;255(15):7397
carbamoyl-phosphate synthetase (N-acetylglutamate)  EC 6.3.4.-   *Carbon-Nitrogen Ligases. Science 1980;208(4441):291
holocarboxylase synthetases  EC 6.3.4.-   *Carbon-Nitrogen Ligases. J Pediatr 1980;96(5):845; Life Sci 19:1377;1976; Proc Soc Exp Biol Med 145(2):565;1974
urea carboxylase (hydrolyzing)  EC 6.3.4.6   *Carbon-Nitrogen Ligases. Anal Biochem 72:468;1976; Biochem Biophys Res Commun 49(1):45;1972; Biochim Biophys Acta 438(2):574;1976; J Biol Chem 247(13):4107;1972; J Biol Chem 248(17):6203;1973; Mol Gen Genet 166(3):251;1978
5-phosphoribosylamine synthetase  EC 6.3.4.7   *Carbon-Nitrogen Ligases. Proc Natl Acad Sci USA 73(7):2458;1976
5'-phosphoribosylimidazoleacetate synthetase  EC 6.3.4.8   *Carbon-Nitrogen Ligases. J Clin Invest 58(1):137;1976
phosphoribosylamine-glycine ligase  EC 6.3.4.13   *Carbon-Nitrogen Ligases. Ciba Found Symp 48:23;1977; J Biol Chem 248(6):1970;1973; Methods Enzymol 51:179;1978
phosphoribosylaminoimidazole synthase  EC 6.3.3.1   *Carbon-Nitrogen Ligases. Somatic Cell Genet 5(2):203;1979
5,10-methenyltetrahydrofolate synthetase  EC 6.3.3.2 5-formyltetrahydrofolate cyclo-ligase (ADP-forming)  *Carbon-Nitrogen Ligases. J Histochem Cytochem 25(5):349;1977
GMP synthase  EC 6.3.4.1   *Carbon-Nitrogen Ligases. J Biol Chem 250(18):7372;1975; J Biol Chem 250(7):2609;1975; J Biol Chem 252(15):5431;1977; Methods Enzymol 51:213;1978; Methods Enzymol 51:219;1978
gamma-glutamylmethylamide synthetase  EC 6.3.4.12   *Carbon-Nitrogen Ligases. Biochem Biophys Res Commun 76(2):609;1977; J Biol Chem 244(15):4136;1969
dethiobiotin synthetase  EC 6.3.3.3   *Carbon-Nitrogen Ligases. Adv Appl Microbiol 22:145;1977; J Bacteriol 123(1):248;1975; J Bacteriol 134(3):1002;1978; J Biol Chem 244(20):5503;1969; Methods Enzymol 62:326;1979; Methods Enzymol 62:348;1979
CTP synthetase  EC 6.3.4.2   *Carbon-Nitrogen Ligases. Adv Enzyme Regul 16:3;1977; J Bacteriol 137(3):1073;1979; J Biol Chem 242:4715;1969; J Biol Chem 245:2529;1970; J Neurochem 22(6):1027;1974; J Neurosci Res 2(5/6):413;1977; Methods Enzymol 51:79;1978; Nature 271(5640):71;1978; Ukr Biokhem Zh 49(3):76;1977
canavaninosuccinate synthetase  EC 6.3.4.-   *Carbon-Nitrogen Ligases. Clin Chem 21(12):1777;1975
biotin carboxylase  EC 6.3.4.14   *Carbon-Nitrogen Ligases. J Am Chem Soc 98(12):3741;1976
N-(5-amino-1-ribosyl-4-imidazolylcarbonyl)-L-aspartic acid 5'-phosphate synthetase  EC 6.3.4.-   *Carbon-Nitrogen Ligases. Methods Enzymol 51:186;1978

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