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Ubiquitin-Activating Enzymes

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Definition: A class of enzymes that catalyzes the ATP-dependent formation of a thioester bond between itself and UBIQUITIN. It then transfers the activated ubiquitin to one of the UBIQUITIN-PROTEIN LIGASES.      Other names Ubiquitin Activating Enzymes; Ubiquitin Activating Enzyme E1; Ubiquitin Activating Enzyme; Enzymes, Ubiquitin-Activating; Enzyme, Ubiquitin-Activating; Enzyme E1, Ubiquitin-Activating; Ubiquitination Activating Enzyme E1; Ubiquitin-Activating Enzyme E1; Ubiquitin-Activating Enzyme
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Uba3 protein, Drosophila  EC 6.3.2.19   *Drosophila Proteins *Ubiquitin-Activating Enzymes. PLoS One. 2011;6(9):e24168.
Uba5 protein, mouse  EC 6.3.2.19   *Ubiquitin-Activating Enzymes. Nat Commun. 2011;2() (dup#27):181
Nae1 protein, rat  0   *Ubiquitin-Activating Enzymes. Neuroreport 2011 Mar 30;22(5):200-5
Atg7 protein, rat  0   *Ubiquitin-Activating Enzymes. Hepatology 2008 May;47(5):1725-36
CsdL protein, E coli  EC 6.3.2.19   *Escherichia coli Proteins *Ubiquitin-Activating Enzymes. Mol Microbiol 2009 Dec;74(6):1527-42
RFL-1 protein, C elegans  EC 6.3.2.19   *Caenorhabditis elegans Proteins *Ubiquitin-Activating Enzymes. Genetics 2009 Aug;182(4):1035-49
Uba1 protein, Drosophila  EC 6.3.2.19   *Drosophila Proteins *Ubiquitin-Activating Enzymes. Fly (Austin). 2007 Mar-Apr;1(2):95-105
UBE1L protein, human  EC 6.3.2.19   *Ubiquitin-Activating Enzymes. Mol Cancer Ther 2008 Dec;7(12):3780-8
E1-L2 protein, mouse  EC 6.3.2.19   *Ubiquitin-Activating Enzymes. Mol Cell 2007 Sep 21;27(6):1014-23
E1-L2 protein, human  EC 6.3.2.19   *Ubiquitin-Activating Enzymes. Mol Cell 2007 Sep 21;27(6):1014-23
UBE1L2 protein, human  EC 6.3.2.19   *Ubiquitin-Activating Enzymes. J Biol Chem 2007 Aug 10;282(32):23010-4
UBA6 protein, human  0   *Ubiquitin-Activating Enzymes. Nature 2007 Jun 28;447(7148):1135-8
Atg7 protein, human  EC 6.3.2.19   *Ubiquitin-Activating Enzymes. Mol Biol Cell 1999 May;10(5):1353-66
UBA5 protein, human  EC 6.3.2.19   *Ubiquitin-Activating Enzymes. EMBO J 2004 May 5;23(9):1977-86
UBA3 protein, human  EC 6.3.2.-   *Ubiquitin-Activating Enzymes.
ptr3 protein, S pombe  EC 6.3.2.19   *Schizosaccharomyces pombe Proteins *Ubiquitin-Activating Enzymes.
Ube1y1 protein, mouse  EC 6.3.2.19   *Ubiquitin-Activating Enzymes.
Ube1x protein, mouse  EC 6.3.2.19   *Ubiquitin-Activating Enzymes. Somat Cell Mol Genet. 1993 Jan;19(1):65-71
UBE1 Protein, human  EC 6.3.2.19   *Ubiquitin-Activating Enzymes.
UBA2 protein, human  EC 6.3.2.19   *Ubiquitin-Activating Enzymes.
SAE1 protein, human  EC 6.3.2.19   *Ubiquitin-Activating Enzymes. J Biol Chem 1999 Apr 9;274(15):10618-24
uba2 protein, Drosophila  EC 6.3.2.19   *Nuclear Proteins *Drosophila Proteins *Ubiquitin-Activating Enzymes. Biochim Biophys Acta 2001 Mar 19;1518(1-2):210-4
Aos1 protein, Drosophila  EC 6.3.2.-   *Ligases *Drosophila Proteins Ubiquitin-Conjugating Enzymes Ubiquitin-Activating Enzymes. J Biol Chem 2000 Feb 11;275(6):4033-40

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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