encyclopedia of medical concepts
ψ 
ψ 

DNA Helicases

More information in Books or onNLM PubMed
Definition: Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate of DNA strands.  do not confuse entry term DNA UNWINDING PROTEINS with DNA UNTWISTING PROTEINS   
Examples DnaB Helicases; RecQ Helicases; Xeroderma Pigmentosum Group D Protein 		Other names DNA Unwinding Proteins; Unwinding Proteins, DNA; Helicases, DNA; Helicases, ATP-Dependent DNA; DNA Helicases, ATP-Dependent; ATP Dependent DNA Helicases; DNA Helicase III; DNA Helicase II; DNA Helicase E; DNA Helicase A; ATP-Dependent DNA Helicases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CHL-1 protein, C elegans  0   *DNA Helicases *Caenorhabditis elegans Proteins. DNA Repair (Amst). 2011 Nov 10;10(11):1174-82.
Chd7 protein, Danio rerio  EC 3.6.1.-   *DNA Helicases *DNA-Binding Proteins *Zebrafish Proteins. Dev Dyn. 2011 Oct;240(10):2272-80
DDX41 protein, mouse  EC 3.6.1.-   *DNA Helicases. Nat Immunol 2011 Oct;12(10):959-65
SMARCAD1 protein, human  EC 3.6.1.-   *DNA Helicases. Genomics. 2000 Oct 15;69(2):162-73
WRN protein, rat  EC 3.6.1.-   *DNA Helicases DNA Repair Werner Syndrome. J Cell Biol 1999 Jan 11;144(1):1-9
ZRANB3 protein, human  EC 3.6.4.-   *DNA Helicases Zinc Fingers. Proc Natl Acad Sci U S A 2010 Dec 7;107(49):20970-3
Fbh1 protein, mouse  EC 5.99.-   *DNA Helicases. DNA Repair (Amst). 2010 Jun 4;9(6):708-17
rad54b protein, mouse  EC 3.6.4.-   *DNA Helicases.
Chd6 protein, mouse  EC 3.6.1.-   *DNA Helicases. Mamm Genome 2010 Apr;21(3-4):130-42
Xpd protein, Drosophila  EC 3.6.1.-   *DNA Helicases *Drosophila Proteins Cell Cycle Proteins. PLoS Genet 2010;6(3):e1000876
CHD7 protein, Xenopus  EC 5.99.-   *DNA Helicases *DNA-Binding Proteins *Xenopus Proteins. Nature. 2010 Feb 18;463(7283):958-62
XPF-1 protein, C elegans  EC 3.1.-   *DNA Helicases *Caenorhabditis elegans Proteins. PLoS Genet 2009 Nov;5(11):e1000735
HELQ-1 protein, C elegans  EC 3.6.1.-   *DNA Helicases *Caenorhabditis elegans Proteins. Mol Cell 2010 Jan 29;37(2):259-72
MOV10 protein, rat  EC 3.6.1.-   *DNA Helicases. Neuron 2009 Dec 24;64(6):871-84
RAD54L2 protein, human  EC 3.6.4.12   *DNA Helicases. Mol Biol Cell 2009 Oct;20(19):4235-45
TDRD9 protein, mouse  EC 3.6.1.-   *DNA Helicases. Dev Cell 2009 Dec;17(6):775-87
CHDL1 protein, mouse  EC 3.6.1.-   *DNA Helicases *DNA-Binding Proteins Tumor Markers, Biological. PLoS One. 2009;4(8) (dup#10):e6727
FANCM protein, Xenopus  EC 3.6.1.-   *DNA Helicases *Xenopus Proteins. J Biol Chem 2009 Sep 18;284(38):25560-8
CHD1L protein, human  EC 3.6.1.-   *DNA Helicases *DNA-Binding Proteins Tumor Markers, Biological. Science. 2009 Sep 4;325(5945):1240-3
sen1 protein, S pombe  EC 3.6.1.-   *DNA Helicases *RNA Helicases.
SEN1 protein, S cerevisiae  EC 3.6.1.-   *DNA Helicases *RNA Helicases *Saccharomyces cerevisiae Proteins.
RDH54 protein, S cerevisiae  EC 5.99.1.-   *DNA Helicases *DNA Topoisomerases.
XNP protein, Drosophila  EC 3.6.1.-   *DNA Helicases *Drosophila Proteins. Biochem Biophys Res Commun 2009 Jun 26;384(2):160-6
Snf21 protein, S pombe  EC 3.6.1.-   *DNA Helicases *Schizosaccharomyces pombe Proteins. Genes Genet Syst 2008 Oct;83(5):361-72
DNA2 protein, Xenopus  0   *DNA Helicases *Endonucleases *Xenopus Proteins. Nucleic Acids Res 2008 Nov;36(19):6091-100
RTEL1 protein, C elegans  EC 3.6.1.-   *DNA Helicases *Caenorhabditis elegans Proteins. Cell 2008 Oct 17;135(2):261-71
RTEL1 protein, human  EC 3.6.1.-   *DNA Helicases. Cell 2008 Oct 17;135(2):261-71
ERI-6 protein, C elegans  EC 3.6.1.-   *DNA Helicases *Caenorhabditis elegans Proteins. Nature 2008 Sep 25;455(7212):491-6
ERI-7 protein, C elegans  EC 3.6.1.-   *DNA Helicases *Caenorhabditis elegans Proteins. Nature 2008 Sep 25;455(7212):491-6
BILS 22 BS  0   *Thiazoles DNA Helicases/antagonists & inhibitors DNA Primase/antagonists & inhibitors. J Antimicrob Chemother 2008 May;61(5):1044-7
Ruvb-1 protein, C elegans  EC 3.6.1.-   *DNA Helicases *Caenorhabditis elegans Proteins. Genetics 2007 Oct;177(2):819-33
CHD3 protein, Drosophila  EC 3.6.1.3   *DNA Helicases *Drosophila Proteins. Nature 2005 Dec 22;438(7071):1181-5
regulator of telomere length protein, mouse  EC 3.6.1.-   *DNA Helicases. Genesis 2007 Dec;45(12):788-92
TIP49 protein, mouse  EC 3.6.1.-   *DNA Helicases. Mol Cell Biol 2007 Oct;27(19):6782-93
TIP48 protein, mouse  EC 3.6.1.-   *DNA Helicases. Mol Cell Biol 2007 Oct;27(19):6782-93
INO80 protein, human  EC 3.6.1.-   *DNA Helicases. Nat Struct Mol Biol 2007 Sep;14(9):872-4
HFM1 protein, human  EC 3.6.1.-   *DNA Helicases. DNA Seq 2006 Jun;17(3):242-6
RAD54 protein, Arabidopsis  0   *DNA Helicases *Arabidopsis Proteins. Plant J 2006 Dec;48(6):827-42
RUVBL2 protein, mouse  EC 3.6.4.12   *DNA Helicases. Mol Reprod Dev 2006 Apr;73(4):437-45
FANCM protein, human  EC 3.6.1.-   *DNA Helicases. Nat Genet 2005 Sep;37(9):958-63
Pif1 protein, mouse  EC 5.99.-   *DNA Helicases. Mol Cell Biol 2007 Feb;27(3):1017-26
ERCC6L protein, human  EC 3.6.1.-   *DNA Helicases Cell Cycle Proteins. Cell 2007 Jan 12;128(1):20-1
MCM4 protein, mouse  EC 3.6.1.-   *DNA Helicases. Genomics 1998 Jan 1;47(1):71-83
Brg1 protein, zebrafish  EC 3.6.1.-   *DNA Helicases *Zebrafish Proteins Intracellular Signaling Peptides and Proteins. Dev Dyn 2006 Oct;235(10):2722-35
SHPRH protein, human  0   *DNA Helicases *Ubiquitin-Protein Ligases Tumor Suppressor Proteins. Proc Natl Acad Sci U S A 2006 Nov 28;103(48):18107-12
RecQ4A protein, Arabidopsis  EC 5.99.-   *DNA Helicases *Arabidopsis Proteins. Nucleic Acids Res 2006;34(16):4438-48
Peo1 protein, mouse  EC 3.6.1.-   *DNA Helicases *Mitochondrial Proteins.
Smarca4 protein, mouse  EC 3.6.1.-   *DNA Helicases *Nuclear Proteins *Transcription Factors.
Ercc6 protein, rat  EC 3.6.1.-   *DNA Helicases *DNA Repair Enzymes.
TEBICHI protein, Arabidopsis  EC 2.7.7.-   *DNA-Directed DNA Polymerase *Arabidopsis Proteins DNA Helicases. Plant Cell 2006 Apr;18(4):879-92
DNA2 protein, human  EC 3.6.1.-   *DNA Helicases. Nucleic Acids Res 2006;34(6):1854-64
Mi-2beta protein, mouse  EC 3.6.1.3   *DNA Helicases. J Biol Chem 2002 Apr 12;277(15):13007-15
PIF1 protein, human  EC 5.99.-   *DNA Helicases Telomerase/antagonists & inhibitors. Nucleic Acids Res 2006;34(5):1393-404
Chd7 protein, mouse  0   *DNA-Binding Proteins DNA Helicases. Hum Mol Genet. 2005 Nov 15;14(22):3463-76
WRN protein, Xenopus  EC 5.99.-   *DNA Helicases *Xenopus Proteins Adenosine Triphosphatases Exonucleases. Cell Biol 2005 Oct 24;171(2):217-27
UvrD protein, E coli  EC 3.6.1.-   *DNA Helicases *Escherichia coli Proteins.
RIS1 protein, S cerevisiae  EC 3.6.1.-   *DNA Helicases *Saccharomyces cerevisiae Proteins.
rep protein, E coli  0   *DNA Helicases *Escherichia coli Proteins.
priA protein, E coli  EC 3.6.1.-   *DNA Helicases *Escherichia coli Proteins.
MGS1 protein, S cerevisiae  EC 3.6.1.-   *DNA Helicases *Saccharomyces cerevisiae Proteins.
more...

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy