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Pyrimidine Dimers

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Definition: Dimers found in DNA chains damaged by ULTRAVIOLET RAYS. They consist of two adjacent PYRIMIDINE NUCLEOTIDES, usually THYMINE nucleotides, in which the pyrimidine residues are covalently joined by a cyclobutane ring. These dimers block DNA REPLICATION.     
See Also DNA Damage 		Other names Thymine Thymine Cyclobutane Dimer; Thymine Cyclobutane Dimer; Dimers, Thymine; Dimers, Pyrimidine; Dimers, Cytosine-Thymine; Dimers, Cyclobutane-Pyrimidine; Dimer, Thymine-Thymine Cyclobutane; Dimer, Thymine-Cyclobutane; Cytosine Thymine Dimers; Cyclobutane Pyrimidine Dimers; Cyclobutane Dimer, Thymine-Thymine; Thymine-Thymine Cyclobutane Dimer; Thymine-Cyclobutane Dimer; Cytosine-Thymine Dimers; Cyclobutane-Pyrimidine Dimers; Thymine Dimers
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Ddb2 protein, mouse  0   *DNA-Binding Proteins DNA Damage Pyrimidine Dimers. Gene 2000 Mar 7;245(1):151-9
1,3-dimethylthymine cyclobutane dimer  7025-74-3   *Pyrimidine Dimers. Photochem Photobiol 1990;52(5):973
cyclobutyldithymidine dimers  33407-74-8   *Pyrimidine Dimers. Carcinogenesis 1989;10(4):641
pyrimidine-pyrimidone dimer  0   *Pyrimidine Dimers. Photochem Photobiol 1988;48(1):41
5-hydroxy-6-(4-(5'-methylpyrimidine-2'-one)dihydrothymine)  20545-93-1   *Pyrimidine Dimers. Int J Radiat Biol 1986;50(4):641
quasimetacyclophane  68675-79-6 4H,9H-5,8-Propano-1H-3a,5,8,9a-tetraazacyclohepta(def)biphenylene-4,6,7,9-tetrone, hexahydro-6a,6b-dimethyl  *Pyrimidine Dimers. Biochem Biophys Res Commun 91(1):375;1979
1-methylthymine cyclobutane dimer  0   *Pyrimidine Dimers. Acta Biochim Pol 20(3):297;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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