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Dihydroergotoxine

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Definition: A mixture of three different hydrogenated derivatives of ERGOTAMINE: DIHYDROERGOCORNINE; DIHYDROERGOCRISTINE; and DIHYDROERGOCRYPTINE. Dihydroergotoxine has been proposed to be a neuroprotective agent and a nootropic agent. The mechanism of its therapeutic actions is not clear, but it can act as an alpha-adrenergic antagonist and a dopamine agonist. The methanesulfonate salts of this mixture of alkaloids are called ERGOLOID MESYLATES.     
Pharmacological Action Adrenergic alpha-Antagonists; Dopamine Agonists
See Also Dihydroergocornine; Dihydroergocristine; Dihydroergocryptine
Examples Ergoloid Mesylates 		Other names Ergot Alkaloids, Hydrogenated; Co-Dergocrine; Hydrogenated Ergot Alkaloids; Alkaloids, Hydrogenated Ergot; DihydroergotoxinDrugs* : HYDROGENATED ERGOT ALKALOIDS
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Ersilan  135556-19-3   *Dihydroergotoxine Drug Combinations Theophylline/*analogs & derivatives. Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralov 1988;31(5 Suppl):649
Vasobral  94423-99-1   *Caffeine *Dihydroergotoxine Drug Combinations. Arm Radiol 1987;30(6):425
sinepres  117178-63-9   *Dihydroergotoxine *Hydrochlorothiazide *Reserpine Drug Combinations. Klin Med (Mosk) 1987;65(4):30
P 3007  115756-35-9   *Dihydroergotoxine Drug Combinations 5-Hydroxytryptophan/*analogs & derivatives. Clin Ther 1987;9(3):267
chlorthalidone, dihydroergocristine mesilate, metipranolol drug combination  0   *Chlorthalidone *Dihydroergotoxine *Metipranolol Drug Combinations. Cas Lek Cesk 1983;122(29):906
dihydroergotoxine ethansulfonate  1401-12-3   Dihydroergotoxine. Nouv Presse Med 7(24):2175;1978; Ther Hung 25(4):145;1977
dihydroergotamine, dihydroergotoxine drug combination  0   *Dihydroergotamine *Dihydroergotoxine Drug Combinations. Fortschr Med 4(27):1502;1976; Fortschr Med 96(34):1735;1978
Iskedyl  96743-85-0 Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, (19alpha)-, mixt. with (5'alpha,10alpha)-9,10-dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)ergotaman-3',6',18-trione  *Dihydroergotoxine *Yohimbine Drug Combinations. Ann Anesthesiol Fr 16(2):69;1975; J Fr Otorhinolaryngol 23(7):649;1974
dihydroergotoxin, p-aminobenzoyl-N-diethyl-leucinol drug combination  0   *Dihydroergotoxine Drug Combinations Procaine/*analogs & derivatives. Klin Oczna 44(7):661;1974; Pol Tyg Lek 33(41):1619;1978; Rev Med-Chirurg 69(3):407;1975
sandoven  61498-93-9   *Dihydroergotoxine *Esculin *Rutin Drug Combinations. Praxis 64(41):1320;1975
clopamide, dihydroergotoxine, reserpine drug combination  0   *Clopamide *Dihydroergotoxine *Reserpine Drug Combinations. Praxis 63(47):1409;1974
Eutergine  0   *Dihydroergotoxine *Papaverine *Sparteine Drug Combinations Cerebrovascular Disorders/drug therapy. Lille Med 17(5):819;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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