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Sparteine

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Definition: A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype.     
Pharmacological Action Anti-Arrhythmia Agents; Oxytocics 		Other names Pachycarpine; beta Isosparteine; alpha Isosparteine; beta-Isosparteine; alpha-Isosparteine; Sparteine, (7S-(7alpha,7abeta,14alpha,14abeta))-Is; Sparteine, (7S-(7alpha,7aalpha,14alpha,14abeta))-I; Sparteine, (7S-(7alpha,7aalpha,14alpha,14aalpha)); Sparteine, (7R-(7alpha,7abeta,14alpha,14abeta))-Is; Sparteine, (7R-(7alpha,7aalpha,14alpha,14abeta))-I; Sparteine, (-)-Isomer; Sparteine, (+)-Isomer; Sparteine Sulfate (1:1), (7S-(7alpha,7aalpha,14alp; Sparteine Sulfate (1:1), (7S-(7alpha,7aalpha,14alp; Sparteine Sulfate; Sparteine Monohydroiodide, (7R-(7alpha,7aalpha,14a; Sparteine Monohydrochloride, (7R-(7alpha,7aalpha,1; Sparteine Hydroiodide, (7R-(7alpha,7aalpha,14alpha; Sparteine Hydrochloride, (7S-(7alpha,7aalpha,14alp; Sparteine Hydrochloride, (7R-(7alpha,7aalpha,14alp
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
bis(azido-kappaN)(sparteine-kappa(2)N,N')copper(II)  0   *Organometallic Compounds Sparteine/*analogs & derivatives Copper. Acta Crystallogr C 2003 Feb;59(Pt 2):m64-6
2-thionosparteine  0   Sparteine/*analogs & derivatives Stereoisomerism. J Mass Spectrom 2003 Mar;38(3):343-4
(sparteine-N,N')(maleonitriledithiolato-S,S')copper(II)  0   *Organometallic Compounds Sparteine/*analogs & derivatives Copper. Inorg Chem 2001 Aug 13;40(17):4481-4
5,6-dehydrolupanine  0   *Azocines *Sparteine. Arch Pharm Res 1994 Dec;17(6):393-7
sparteine N-16-oxide  0   *Cyclic N-Oxides Sparteine/*analogs & derivatives. Acta Pharm Hung 1997 Jan;67(1):9-12
angustifoline  550-43-6   Sparteine/*analogs & derivatives. Food Chem Toxicol 1996 Aug;34(8):679-86
13-hydroxylupanine  15358-48-2   Sparteine/*analogs & derivatives. Xenobiotica 1994 Sep;24(9):933-41
2-hydroxysparteine  137622-83-4   Sparteine/*analogs & derivatives. Br J Clin Pharmacol 1993 Apr;35(4):426-30
N-methylalbine  6822-63-5 1,5-Methano-10H-pyrido(1,2-a)(1,5)diazocin-10-one, 1,2,3,4,5,6,11,11a-octahydro-3-methyl-2-(2-propenyl)-, (1S-(1alpha,2alpha,5alpha,11aalpha))  Sparteine/*analogs & derivatives. Planta Med 1988;54(6):522
2-dehydrosparteine  67528-17-0   Sparteine/*analogs & derivatives. Clin Pharmacol Ther 1985;37(5):512
5-dehydrosparteine  2130-67-8   Sparteine/*analogs & derivatives. Clin Pharmacol Ther 1985;37(5):512
10,17-dioxosparteine  52717-73-4   Sparteine/*analogs & derivatives. J Agric Food Chem 1982;30(4):796
17-oxosparteine  489-72-5   Sparteine/*analogs & derivatives. J Agric Food Chem 1982;30(4):796
17-pentylsparteine  52670-65-2   Sparteine/*analogs & derivatives. Arzneim Forsch 1980;30(9):1497
17-butylsparteine  52670-57-2   Sparteine/*analogs & derivatives. Arzneim Forsch 1980;30(9):1497
lupinine  486-70-4 octahydroquinolizine-1-methanol  Sparteine/*analogs & derivatives. Farmakol Toksikol 1979;42(6):628; Farmakol Toksikol 41(1):52;1978; Zh Evol Biokhim Fiziol 1980;16(3):244
13-hydroxylupanine-2-pyrrolecarbonic acid  6874-80-2 (2S-(2 alpha,7 beta,7a beta,14 beta,14a alpha))-1H-pyrrole-2-carboxylic acid, dodecahydro-11-oxo-7,14-methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocin-2-yl ester  Sparteine/*analogs & derivatives. Arzneim Forsch 26(9):1651;1976
pulsnorma  78571-97-8 Ajmalan-17,21-diol, (17R,21alpha)-, mixt. with 4,5-dihydro-N-phenyl-N-(phenylmethyl)-1H-imidazole-2-methanamine monohydrochloride, 5-ethyl-5-(1-methylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetrione and (7S-(7alpha,7aalpha,14alpha,14abeta))-dodecahydro-7,14-meth  *Ajmaline *Antazoline *Phenobarbital *Sparteine Drug Combinations. Klin Med (Mosk) 53(7):57;1975
lupanine  550-90-3   Sparteine/*analogs & derivatives. Acta Biochim Pol 24(3):225;1977; Arch Int Pharmacodyn Ther 210(1):27;1974; Planta Med 28(2):139;1975
lindenianine  52539-65-8 13-beta-hydroxy-10-oxosparteine  Sparteine/*analogs & derivatives. J Org Chem 39(24):3584;1974
Eutergine  0   *Dihydroergotoxine *Papaverine *Sparteine Drug Combinations Cerebrovascular Disorders/drug therapy. Lille Med 17(5):819;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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