Definition: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
80186-95-4
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl-, mixt. with 2,2-bis(hydroxymethyl)-1,3-propanediol, 1-((3,4-diethoxyphenyl)methylene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride and 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione compd. wi
63952-75-0
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta(S*)))-, mixt. with 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxyisoquinoline hyd
Arch Int Pharmacodyn Ther 221(1):163;1976; Arzneim Forsch 28(5):794;1978; C R Soc Biol (Paris) 171(1):214;1977; C R Soc Biol (Paris) 171(5):1075;1977; Curr Ther Res 16(10):1096;1974; Fortschr Med 95(47-48):2829;1977; J Pharmacol Exp Ther 204(3):645;1978