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Cathepsins

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Definition: A group of lysosomal proteinases or endopeptidases found in aqueous extracts of a variety of animal tissues. They function optimally within an acidic pH range. The cathepsins occur as a variety of enzyme subtypes including SERINE PROTEASES; ASPARTIC PROTEINASES; and CYSTEINE PROTEASES.  note specifics   
Examples Cathepsin A; Cathepsin B; Cathepsin C; Cathepsin D; Cathepsin E; Cathepsin F; Cathepsin G; Cathepsin H; Cathepsin K; Cathepsin L; Cathepsin W; Cathepsin Z 		Other names Cathepsin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Ctso protein, mouse  EC 3.4.22.42   *Cathepsins.
CTSO protein, human  EC 3.4.22.42   *Cathepsins.
CsCF-6 protein, Clonorchis sinensis  EC 3.4.-   *Cathepsins *Helminth Proteins. Int J Parasitol 2008 Apr;38(5):493-502
Ctsla protein, zebrafish  EC 3.4.22.-   *Cathepsins *Zebrafish Proteins Cysteine Endopeptidases. Gene 2007 Jan 15;386(1-2):98-106
procathepsin X, human  EC 3.4.-   *Cathepsins *Protein Precursors. J Mol Biol 2000 Jan 28;295(4):939-51
cathepsin L1, Fasciola hepatica  EC 3.4.22.-   *Cathepsins. Int J Parasitol 2005 Sep;35(10):1115-25
AhCP1 enzyme  EC 3.4.22.16   *Cathepsins Acanthamoeba Cysteine Endopeptidases. Korean J Parasitol 2002 Mar;40(1):17-24
Artemia cathepsin L-like protease  EC 3.4.22.-   *Cathepsins *Cysteine Endopeptidases. Biochem Cell biol 2001;79(1):43-56
cathepsin L5  EC 3.4.22.-   *Cathepsins. Protein Sci 2000 Dec;9(12):2567-72
5-(2-morpholin-4-ylethoxy)benzofuran-2-carboxylic acid (3-methyl-1-(3-oxo-1-(2-(3-pyridin-2-ylphenyl)acetyl)azepan-4-ylcarbamoyl)butyl)amide  0   *Azepines Leucine/*analogs & derivatives Cathepsins/antagonists & inhibitors. J Med Chem 2001 Apr 26;44(9):1380-95
cathepsin-6  EC 3.4.22.-   *Cathepsins. Biochem J 2000 Aug 1;349 Pt 3:689-92
Cts8 protein, mouse  0   *Cathepsins. Dev Biol 2000 Jun 1;222(1):158-69
Cts7 protein, mouse  0   *Cathepsins. Dev Biol 2000 Jun 1;222(1):158-69
cathepsin Q  EC 3.4.22.-   *Cathepsins *Cysteine Endopeptidases. Biochem Biophys Res Commun 2000 Jan 27;267(3):791-5
cathepsin Y  EC 3.4.22.-   *Cathepsins *Cysteine Endopeptidases. Immunopharmacology 1999 Dec;45(1-3):207-14
diaminopyrrolidinone  0   *Pyrrolidinones Cathepsins/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Jul 19;9(14):1907-10
WF 14861  0   *Epoxy Compounds Tyrosine/analogs & derivatives Cathepsins/antagonists & inhibitors. J Antibiot (Tokyo) 1999 Jun;52(6):536-41
CTSL2 protein, human  EC 3.4.22.43   *Cathepsins *Cysteine Endopeptidases. Biochemistry 1999 Feb 23;38(8):2377-85
silicatein alpha  0   *Cathepsins. Proc Natl Acad Sci U S A 1998 May 26;95(11):6234-8
phytepsin  EC 3.4.23.40   *Cathepsins *Aspartic Acid Endopeptidases. Eur J Biochem 1991 Dec 18;202(3):1021-7
procathepsin K, Ser(139)-Ala(163)  0   *Cathepsins *Enzyme Precursors. J Biol Chem 1997 May 23;272(21):13955-60
N-(benzyloxycarbonyl)-phenylalanyl-tyrosinal  0   *Dipeptides Cathepsins/antagonists & inhibitors. Eur J Pharmacol 1996 Apr 4;300(1-2):131-5
preprocathepsin C  EC 3.4.22.-   *Cathepsins *Enzyme Precursors. FEBS Lett 1995 Aug 7;369(2-3):326-30
cat-L1B protein, Fasciola gigantica  EC 3.4.22   *Cathepsins *Cysteine Endopeptidases *Helminth Proteins. Biochem Mol Biol Int 1993 Nov;31(3):537-42
preprocathepsin H  EC 3.4.22.-   *Cathepsins *Enzyme Precursors. Nucleic Acids Res 1989;17(22):9471
preprocathepsin B  EC 3.4.22.-   *Cathepsins *Enzyme Precursors. Biol Chem Hoppe Seyler 1988;369 Suppl:163
preprocathepsin L  EC 3.4.22.-   *Cathepsins *Enzyme Precursors. J Clin Invest 1988;81(5):1621
cathepsin J  EC 3.4.22.-   *Cathepsins. Biochem Biophys Res Commun 1984;124(3):909
cathepsin M  EC 3.4.99.-   *Cathepsins. Arch Biochem Biophys 1982;213(2):731
leupeptin  24365-47-7 L-Leucinamide, N-acetyl-L-leucyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)  *Leupeptins Cathepsins/antagonists & inhibitors.
Pharma Action Cysteine Proteinase Inhibitors 		Biochim Biophys Acta 1981;661(2):175
cathepsin T  EC 3.4.22.24   *Cathepsins. Biochim Biophys Acta 1981;659(1):114; J Biol Chem 1980;255(15):7371
cathepsin N  EC 3.4.22.-   *Cathepsins. Ciba Found Symp 1979;75:13
cathepsin S  EC 3.4.22.27   *Cathepsins. Ciba Found Symp 1979;75:13
E 64  66701-25-5 Oxiranecarboxylic acid, 3-(((1-(((4-((aminoiminomethyl)amino)butyl)amino)carbonyl)-3-methylbutyl)amino)carbonyl)-, (2S-(2alpha,3beta(R*)))  Leucine/*analogs & derivatives Cathepsins/antagonists & inhibitors.
Pharma Action Antimalarials ; Cysteine Proteinase Inhibitors 		Biochem Biophys Res Commun 1980;93(3):713

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