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Aspartic Acid Endopeptidases

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Definition: A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity.     
Examples Cathepsin D; Cathepsin E; Chymosin; HIV Protease; Pepsin A; Renin 		Other names Aspartic Endopeptidases; Endopeptidases, Aspartyl; Endopeptidases, Aspartic Acid; Acid Endopeptidases, Aspartic; Aspartyl Endopeptidases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SPPL2b protein, mouse  EC 3.4.23.-   *Membrane Proteins *Aspartic Acid Endopeptidases. FEBS Lett. 2011 Oct 3;585(19):2951-7.
SPPL2a protein, mouse  EC 3.4.23.-   *Membrane Proteins *Aspartic Acid Endopeptidases. FEBS Lett. 2011 Oct 3;585(19):2951-7.
aspartic proteinase A1 protein, Arabidopsis  EC 3.4.23.-   *Aspartic Acid Endopeptidases *Arabidopsis Proteins. Phytochemistry. 2010 Apr;71(5-6):515-23
SPP protein, Arabidopsis  EC 3.4.23.-   *Aspartic Acid Endopeptidases *Arabidopsis Proteins. Plant Physiol 20090 Mar;149(3):1289-301
Gvp36 protein, S cerevisiae  EC 3.4.23.-   *Aspartic Acid Endopeptidases *Saccharomyces cerevisiae Proteins. J Biol Chem. 2008 Feb 22;283(8):4730-43
SPPL2b protein, human  EC 3.4.23.-   *Aspartic Acid Endopeptidases Membrane Proteins. J Biol Chem 2008 Jan 18;283(3):1644-52
SPPL2a protein, human  EC 3.4.23.-   *Aspartic Acid Endopeptidases. Cell Death Differ 2007 Sep;14(9):1678-87
SPPL2b protein, zebrafish  EC 3.4.23.-   *Aspartic Acid Endopeptidases *Zebrafish Proteins. J Biol Chem 2005 Nov 25;280(47):39515-23
signal peptide peptidase like 3, human  EC 3.4.23.-   *Aspartic Acid Endopeptidases. FASEB J 2006 Aug;20(10):1671-9
Taps protein, mouse  0   *Aspartic Acid Endopeptidases. Am J Pathol 2006 Apr;168(4):1354-64
Bace2 protein, rat  EC 3.4.23.45   *Aspartic Acid Endopeptidases *Amyloid Precursor Protein Secretases.
Bace2 protein, mouse  0   *Aspartic Acid Endopeptidases *Amyloid Precursor Protein Secretases.
BACE2 protein, human  EC 3.4.23.45   *Aspartic Acid Endopeptidases *Amyloid Precursor Protein Secretases.
Bace1 protein, mouse  EC 3.4.23.46   *Aspartic Acid Endopeptidases *Amyloid Precursor Protein Secretases.
Bace protein, rat  EC 3.4.23.46   *Aspartic Acid Endopeptidases *Amyloid Precursor Protein Secretases.
BACE1 protein, human  EC 3.4.23.46   *Aspartic Acid Endopeptidases *Amyloid Precursor Protein Secretases.
skin aspartic protease, human  EC 3.4.23.-   *Aspartic Acid Endopeptidases. J Invest Dermatol 2005 Aug;125(2):278-87
DASP2 protein, Drosophila  EC 3.4.23.-   *Drosophila Proteins *Aspartic Acid Endopeptidases. J Biochem (Tokyo) 2005 Mar;137(3):315-22
DASP1 protein, Drosophila  EC 3.4.23.-   *Aspartic Acid Endopeptidases *Drosophila Proteins. J Biochem (Tokyo) 2005 Mar;137(3):315-22
PCS1 proteinase, Arabidopsis  EC 3.4.23.-   *Aspartic Acid Endopeptidases *Arabidopsis Proteins. EMBO Rep 2005 Mar;6(3):282-8
CDR1 protein, Arabidopsis  EC 3.4.23.-   *Aspartic Acid Endopeptidases *Arabidopsis Proteins. EMBO J 2004 Feb 25;23(4):980-8
PEP4 protein, S cerevisiae  EC 3.4.23.   *Aspartic Acid Endopeptidases *Saccharomyces cerevisiae Proteins.
YPS1 protein, S cerevisiae  EC 3.4.23.25   *Aspartic Acid Endopeptidases *Saccharomyces cerevisiae Proteins.
NAPSA protein, human  EC 3.4.23.-   *Aspartic Acid Endopeptidases.
BAR1 protein, S cerevisiae  EC 3.4.23.-   *Aspartic Acid Endopeptidases *Saccharomyces cerevisiae Proteins.
Ulysses retrotransposon aspartic proteinase, Drosophila  EC 3.4.23.-   *Aspartic Acid Endopeptidases *Drosophila Proteins Retroelements. Vopr Med Khim. 2002 Nov-Dec;48(6):553-60
presenilinase, human  EC 3.4.23.-   *Aspartic Acid Endopeptidases. J Neurochem. 2003 Jun;85(6); 1563-74
signal peptide peptidase  EC 3.4.23.-   *Aspartic Acid Endopeptidases. Science 2002 Jun 21;296(5576):2215-8
plasmapepsin IV  EC 3.4.23.-   *Aspartic Acid Endopeptidases Plasmodium falciparum. FEBS Lett 2002 Feb 27;513(2-3):159-62
mattucinol-7-O-glucopyranoside  0   *Glucosides Aspartic Acid Endopeptidases/antagonists & inhibitors. J Nat Prod 2001 Oct;64(10):1282-5
mattucinol-7-O-(4'',6''-di-O-galloyl)glucopyranoside  0   *Glucosides Aspartic Acid Endopeptidases. J Nat Prod 2001 Oct;64(10):1282-85
mattucinol-7-O-(4' ',6' '-O-hexahydroxydiphenoyl)glucopyranoside  0   *Glucosides Aspartic Acid Endopeptidases/antagonists & inhibitors. J Nat Prod 2001 Oct;64(10):1282-5
alanyl-glycyl-lysyl-lysyl--aspartyl-aspartyl-aspartyl-aspartyl-prolyl-prolyl-glutamic acid  0   *Bacterial Proteins Aspartic Acid Endopeptidases/antagonists & inhibitors. Antimicrob Agents Chemother 2001 Jul;45(7):2008-17
eimepsin  EC 3.4.23.-   *Aspartic Acid Endopeptidases. Gene 2001 Jan 10;262(1-2):129-36
aspartyl protease, Sclerotinia sclerotiorum  EC 3.4.23.-   *Fungal Proteins *Aspartic Acid Endopeptidases. FEMS Microbiol Lett 2001 Jan 1;194(1):27-32
pronapsin  EC 3.4.23.-   *Enzyme Precursors *Aspartic Acid Endopeptidases. Eur J Biochem 2000 Dec;267(23):6921-30
ALP56 enzyme  EC 3.4.23.-   *Aspartic Acid Endopeptidases. Biochim Biophys Acta 2000 Jun 15;1501(2-3):125-37
Kdap protein, rat  EC 3.4.23.-   *Aspartic Acid Endopeptidases. FEBS Lett 1999 Nov 26;462(1-2):129-34
MKC7 protein, S cerevisiae  EC 3.4.23.-   *Aspartic Acid Endopeptidases *Saccharomyces cerevisiae Proteins. Proc Natl Acad Sci U S A 1995 Nov 7;92(23):10752-6
YPS3 protein, S cerevisiae  EC 3.4.23.-   *Aspartic Acid Endopeptidases *Saccharomyces cerevisiae Proteins. Biochem J 1999 Apr 15;339( Pt 2):407-11
proplasmepsin II  EC 3.4.23.-   *Enzyme Precursors *Aspartic Acid Endopeptidases. Nat Struct Biol 1999 Jan;6(1):32-7
MES13-099  0   *Pyrones Aspartic Acid Endopeptidases/antagonists & inhibitors. Biochemistry 1998 Dec 15;37(50):17514-8
Sap9 protein, Candida albicans  EC 3.4.23.-   *Fungal Proteins *Aspartic Acid Endopeptidases. Microbiology 1998 Oct;144( Pt 10):2731-7
Sap8 protein, Candida albicans  EC 3.4.23.-   *Fungal Proteins *Aspartic Acid Endopeptidases. Microbiology 1998 Oct;144( Pt 10):2731-7
procardosin A  EC 3.4.23.-   *Enzyme Precursors *Aspartic Acid Endopeptidases Glycoproteins Plant Proteins. Eur J Biochem 1998 Jul 1;255(1):133-8
Boophilus yolk pro-cathepsin  EC 3.4.23.-   *Enzyme Precursors *Aspartic Acid Endopeptidases. Parasitology 1998 Jun;116( Pt 6):525-32
SQAPI protein, Cucurbita maxima  0   *Plant Proteins Aspartic Acid Endopeptidases/antagonists & inhibitors. Eur J Biochem 1998 May 15;254(1):160-7
podosporapepsin  EC 3.4.23.-   *Fungal Proteins *Aspartic Acid Endopeptidases. Gene 1998 Mar 27;210(1):45-52
nucellin  EC 3.4.23.-   *Aspartic Acid Endopeptidases. Plant Mol Biol 1997 Dec;35(6):821-31
phytepsin  EC 3.4.23.40   *Cathepsins *Aspartic Acid Endopeptidases. Eur J Biochem 1991 Dec 18;202(3):1021-7
PNU 103017  166335-18-8   *Pyrones *Sulfonamides Aspartic Acid Endopeptidases/antagonists & inhibitors. J Chromatogr B Biomed Appl 1997 Jun 20;694(1):169-77
oryzasin  EC 3.4.23.-   *Aspartic Acid Endopeptidases. Eur J Biochem 1995 Aug 15;232(1):77-83
Kdap protein, mouse  EC 3.4.23.-   *Aspartic Acid Endopeptidases. FEBS Lett 1997 Jan 20;401(2-3):218-22
AXP protein, Yarrowia lipolytica  EC 3.4.23.-   *Fungal Proteins *Aspartic Acid Endopeptidases. Microbiology 1996 Oct;142(Pt 10):2913-21
syncephapepsin  EC 3.4.23.-   *Aspartic Acid Endopeptidases. Arch Biochem Biophys 1996 Oct 1;334(1):97-103
Acasp1 protein, Ancylostoma caninum  EC 3.4.23.-   *Helminth Proteins *Aspartic Acid Endopeptidases. Biochem Biophys Res Commun 1996 Oct 3;227(1):294-302
plasmepsin II  EC 3.4.23.39   *Protozoan Proteins *Aspartic Acid Endopeptidases. FEBS Lett 1994 Sep 26;352(2):155-8
aspartic proteinase-I  EC 3.4.23.-   *Aspartic Acid Endopeptidases. J Biol Chem 1996 Jun 14;271(24):14252-5
EapC protein, Cryphonectria parasitica  EC 3.4.23.-   *Fungal Proteins *Aspartic Acid Endopeptidases. Mol Gen Genet 1996 Jan;250(1):97-105
EapB protein, Cryphonectria parasitica  EC 3.4.23.-   *Enzyme Precursors *Fungal Proteins *Aspartic Acid Endopeptidases. Mol Gen Genet 1996 Jan;250(1):97-105
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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