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Cathepsin B

More information in Books or onNLM PubMed
Definition: A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.      Other names Proteinase, Cathepsin B-Like; Cathepsin B Like Proteinase; Cathepsin B1; Cathepsin B-Like Proteinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
benzyloxycarbonyl-arginyl-leucyl-arginyl-alpha-azaglycyl-isoleucyl-valine methyl ester  0   *Oligopeptides Cathepsin B/antagonists & inhibitors. Immunol Lett 2009 Apr 27;123(2):155-9
Ctsb protein, rat  EC 3.4.22.1   *Cathepsin B.
Ctsb protein, mouse  EC 3.4.22.1   *Cathepsin B.
CTSB protein, human  EC 3.4.22.1   *Cathepsin B.
1-(2-((3-(1-(((methoxycarbonylmethyl-carbamoyl)-methyl)-carbamoyl)-3-methyl-butylcarbamoyl)-oxiranecarbonyl)-amino)-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid  0   *Oligopeptides *Pyrroles Cathepsin B/antagonists & inhibitors. Biochem J 2004 Jul 15;381(Pt 2):511-7
CB2 protein, Schistosoma mansoni  EC 3.4.22.1   *Cathepsin B *Helminth Proteins. Mol Biochem Parasitol 2002 Apr 30;121(1):49-61
N-(2-((3-carboxyphenyl)methoxy)-1-cyanoethyl)-3-methyl-Nalpha-(2,4-difluorobenzoyl)phenylalaninamide  0   *Dipeptides *Nitriles Cathepsin B/antagonists & inhibitors. J Med Chem 2001 Dec 20;44(26):4524-34
WF 14865B  0   *Epoxy Compounds Isoleucine/*analogs & derivatives Cathepsin B/antagonists & inhibitors. J Antibiot (Tokyo) 2000 May;53(5):449-58
WF 14865A  0   *Epoxy Compounds Isoleucine/*analogs & derivatives Cathepsin B/antagonists & inhibitors. J Antibiot (Tokyo) 2000 May;53(5):449-58
tokaramide A  0   *Oligopeptides Cathepsin B/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Dec 20;9(24):3397-402
CA 074 methyl ester  0   *Dipeptides Cathepsin B/antagonists & inhibitors. In Vitro Cell Dev Biol Anim 1999 Sep;35(8):459-64
isobutyl-aminoepoxysuccinyl-leucyl-proline  0   *Dipeptides Cathepsin B/antagonists & inhibitors. Protein Eng 1996 Nov;9(11):977-86
N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline  134448-10-5 L-Proline, 1-(N-((3-((propylamino)carbonyl)oxiranyl)carbonyl)-L-isoleucyl)-, (2S-trans)  *Dipeptides Cathepsin B/antagonists & inhibitors.
Pharma Action Cysteine Proteinase Inhibitors ; Neuroprotective Agents 		FEBS Lett 1991;280(2):307
biotin-phenylalanyl-alanine diazomethyl ketone  127678-91-5   Biotin/*analogs & derivatives Diazomethane/*analogs & derivatives Cathepsin B/antagonists & inhibitors. Biochem Soc Trans 1990;18(2):315
procathepsin B  EC 3.4.22.-   *Cathepsin B *Enzyme Precursors. Biol Chem Hoppe Seyler 1988;369 Suppl:163
benzyloxycarbonyltyrosylalanine diazomethane  117176-50-8   *Dipeptides Diazomethane/*analogs & derivatives Cathepsin B/antagonists & inhibitors. Biochem J 1988;254(3):693
MDL 201053  96922-64-4   *Dipeptides *Ketones Cathepsin B/antagonists & inhibitors.
Pharma Action Cysteine Proteinase Inhibitors 		Anticancer Res 1988;8(4):525

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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