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Leucine

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Definition: An essential branched-chain amino acid important for hemoglobin formation.  /biosyn /defic /physiol permitted    Other names Leucine, L Isomer; L-Isomer Leucine; Leucine, L-Isomer; L-Leucine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PG1-E7 compound  0   *Sulfonamides Leucine/*analogs & derivatives. PLoS One. 2011;6(10):e26135.
GGTI 2166  0   Leucine/*analogs & derivatives 4-Aminobenzoic Acid/*analogs & derivatives. Cancer Res. 1999 Oct 1;59(19):4919-26.
(3-ethoxycarbonyloxirane-2-carbonyl)leucine (3-methylbutyl) amide  0   Leucine/*analogs & derivatives. FASEB J. 2011 Oct;25(10):3720-30.
LYP compound  0   Leucine/*analogs & derivatives Antigens, CD13/antagonists & inhibitors. Invest New Drugs. 2011 Aug;29(4):574-82
3,5-dimethoxybenzoyl-leucine diethylamide  0   Leucine/*analogs & derivatives. Chirality. 2011 Apr;23(4):281-6
LYP3 compound  0   Leucine/*analogs & derivatives Aminopeptidases/antagonists & inhibitors. Med Chem. 2011 Jan;7(1):32-6
(Cu((7-hydroxy-4-methyl-8-coumarinyl)leucine)phen(H2O))ClO4  0   *Coumarins *Organometallic Compounds Leucine/*analogs & derivatives Copper. Chem Pharm Bull (Tokyo). 2010;58(8):1003-8
GGTI-2133  0   *Imidazoles *Naphthalenes Leucine/*analogs & derivatives. Int J Immunopathol Pharmacol. 2009 Oct-Dec;22(4):929-35
Org 46035  0   *Pyrimidines Leucine/*analogs & derivatives. Curr Drug Deliv 2009 Oct;6(4):359-66
Org 45697  0   *Pyrimidines Leucine/*analogs & derivatives. Curr Drug Deliv 2009 Oct;6(4):359-66
N-phosphopyridoxylleucine  0   Leucine/*analogs & derivatives Pyridoxal Phosphate/*analogs & derivatives. Proteins 2009 May 1;75(2):348-59
NCI 83633  0   Leucine/*analogs & derivatives 2-Naphthylamine/*analogs & derivatives. RNA 2009 Mar;15(3):483-92
methacryloyl-L-leucine  0   Leucine/*analogs & derivatives. J Phys Chem B. 2008 Sep 25;112(38):11896-906
(N-(9-fluorenylmethoxycarbonyl)-)-L-leucine  0   Leucine/*analogs & derivatives. Biomed Pharmacother. 2008 Apr-May;62(4):259-63
N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide  0   *Sulfonamides Leucine/*analogs & derivatives. J Pharmacol Exp Ther 2008 Aug;326(2):432-42
MeBS compound  0   Leucine/*analogs & derivatives. Bioorg Med Chem Lett 2008 Jun 1;18(11):3354-8
N-(12-imidazolyldodecanoyl)leucine  0   *Imidazoles Leucine/*analogs & derivatives. Biochemistry 2008 Mar 25;47(12):3662-70
(-)-N-((2S,3R)-3-amino-2-hydroxy-4-phenyl-butyryl)-L-leucine methyl ester  0   Leucine/*analogs & derivatives. J Biol Chem 2008 Apr 4;283(14):8961-8
N-palmitoylleucine  0   Leucine/*analogs & derivatives. Biochemistry 2007 Dec 11;46(49):14010-7
urukthapelstatin A  0   *Thiazoles Leucine/*analogs & derivatives. J Antibiot (Tokyo) 2007 Apr;60(4):251-5
N-(2-carboxybenzoyl)leucine  0   *Benzoic Acids Leucine/*analogs & derivatives. Acta Crystallogr C 2006 May;62(Pt 5):o237-9
4-(2-(4-(4-((1-(4-(6-methoxyquinolin-8-ylamino)pentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)phenoxy)benzamido)-3-methylpentanamido)-3-hydroxy-6-methylheptanoic acid butylamide  0   *Aminoquinolines Leucine/*analogs & derivatives. J Med Chem 2006 Dec 14;49(25):7440-9
sodium N-(4-n-dodecyloxybenzoyl)-L-leucinate  0   *Benzoates Leucine/*analogs & derivatives. J Chromatogr A. 2006 Sep 22;1128(1-2):259-66
N-4-(1H-2-methylimidazo(4,5-c)pyridylmethyl)phenylsulfonyl-leucinyl ethyl ether  0   *Sulfonamides Leucine/*analogs & derivatives Platelet Activating Factor/antagonists & inhibitors. Br J Pharmacol 2006 Oct;149(3):269-76
BE15 compound  0   Leucine/*analogs & derivatives. Biol Pharm Bull. 2006 Apr;29(4):709-12
dirhodium(II) tetrakis(N-phthaloyl-(S)-tert-leucinate)  0   *Organometallic Compounds Leucine/*analogs & derivatives Rhodium. Chem Pharm Bull (Tokyo) 2005 Oct;53(10):1366-8
3,4-dihydroxyphenylpropionylleucinamide  0   *Caffeic Acids Leucine/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Biochem Mol Toxicol 2005;19(1):25-31
N-((1S)-1-(((1-(2-diazoacetyl)butyl)amino)carbonyl)-3-methylbutyl)-4'-iodo-(1,1'-biphenyl)-4-carboxamide  0   *Biphenyl Compounds Leucine/*analogs & derivatives. Anal Biochem 2004 Dec 15;335(2):218-27
(S)-gamma-fluoroleucine ethyl ester  0   Leucine/*analogs & derivatives. J Org Chem. 2005 Mar 18;70(6):2372-5
poly(N-undecenoxycarbonylleucinate)  0   *Polymers Leucine/*analogs & derivatives. Electrophoresis 2004 Mar;25(6):853-60
N-acetyl-leucine-methylamide  0   Leucine/*analogs & derivatives. Biophys J 2004 Mar;86(3);1852-62
2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid  0   *Imidazoles Leucine/*analogs & derivatives. J Biol Chem 2004 Apr 23;279(17):17996-8007
3-hydroxyleucine  0   Leucine/*analogs & derivatives. Org Lett 2002 Dec 12;4(25);4511-4
leucinethiol  0   *Sulfhydryl Compounds Leucine/*analogs & derivatives. J Cell Physiol 2002 Nov;93(2):253-62
GGTI 2147  0   *Imidazoles Leucine/*analogs & derivatives. J Pharmacol Exp Ther 2002 Oct;303(1):82-8
N'-(N-(3-hydroxybetulin-28-oyl)-11-aminoundecanoyl)leucine  0   *Triterpenes Leucine/*analogs & derivatives. J Med Chem 2002 Sep 12;45(19):4271-5
dinitrobenzoyl leucine  0   *Dinitrobenzenes Leucine/*analogs & derivatives. J Am Chem Soc 2002 Jul 24;124(29):8611-29
hexafluoroleucine  0   Leucine/*analogs & derivatives. J Am Chem Soc 2001 Nov 28;123(47):11815-6
1-fluoro-2,4-dinitrophenyl-5-leucinamide  0   *Nitro Compounds Leucine/*analogs & derivatives. J Chromatogr A 2001 Jul 6;921(2):187-95
GGTI 286  0   Leucine/*analogs & derivatives. Am J Physiol Lung Cell Mol Physiol 2001 Oct;281(4):L824-31
aeruginosin 298-B  0   *Indoles Leucine/*analogs & derivatives. Chemistry 2001 Aug 17;7(16):3446-60
dimer E.P peptide  0   *Peptides Leucine Valine. J Am Chem Soc 2001 Mar 7;123(9):1797-803
N-benzyloxycarbonylprolyl-leucine  0   Leucine/*analogs & derivatives. Acta Crystallogr C 2001 Aug;57(Pt 8):975-7
5,5,5,5',5',5'-hexafluoroleucine  0   Leucine/*analogs & derivatives. Org Lett 2001 May 3;3(9):1285-6
N-(4-(4-((2-hydroxy-2-(4-hydroxy-3-((methylsulfonyl)amino)phenyl)ethyl)amino)-1-piperidinyl)benzoyl)leucine  0   *Sulfonamides Leucine/*analogs & derivatives. J Med Chem 2001 Apr 26;44(9):1456-66
5-(2-morpholin-4-ylethoxy)benzofuran-2-carboxylic acid (3-methyl-1-(3-oxo-1-(2-(3-pyridin-2-ylphenyl)acetyl)azepan-4-ylcarbamoyl)butyl)amide  0   *Azepines Leucine/*analogs & derivatives Cathepsins/antagonists & inhibitors. J Med Chem 2001 Apr 26;44(9):1380-95
aeruginosin 298-A  0   Leucine/*analogs & derivatives. Org Lett 2000 Dec 28;2(26):4213-6
DCG 04  0   Leucine/*analogs & derivatives. Chem Biol 2000 Aug;7(8):569-81
DCG 03  0   Leucine/*analogs & derivatives. Chem Biol 2000 Aug;7(8):569-81
leucinol  7533-40-6   Leucine/*analogs & derivatives. J Cell Biochem 2000 Sep 7;79(3):427-41
N-(1-naphthyl)leucine ester  0   *Naphthalenes Leucine/*analogs & derivatives. Anal Chem 2000 Nov 1;72(21):5459-65
JPM 565  0   Leucine/*analogs & derivatives. Chem Biol 2000 Jan;7(1):27-38
poly(leucine)-poly(ethylene glycol)-poly(leucine) triblock copolymer  0   *Leucine *Polyethylene Glycols. Biomaterials 2000 Jan;21(2):131-41
2,2'-N,N'-bis(benzyloxycarbonyl)-leucinylcarbohydrazide  0   *Hydrazines Leucine/*analogs & derivatives. Biochemistry 1999 Nov 30;38(48):15893-902
PD 181283  0   *Aniline Compounds Leucine/*analogs & derivatives Calcium Channels, N-Type/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Aug 16;9(16):2453-8
Carisolv  0   *Leucine *Lysine *Glutamic Acid Dental Cavity Preparation. Caries Res 1999 May-Jun;33(3):171-7
N-acetylleucinamide  0   Leucine/*analogs & derivatives. Proc Natl Acad Sci U S A 1999 Jan 19;96(2):424-8
N-formyl-1-((3-hexyl-4-methylene-2-oxetanyl)methyl)dodecyl 2-amino-4-methylpentanoate  0   *Heterocyclic Compounds, 1-Ring Leucine/*analogs & derivatives Lipase/antagonists & inhibitors. Bioorg Med Chem Lett 1998 Apr 21;8(8):977-8
acetyl-leucinal-leucinal-normethional  0   Leucine/*analogs & derivatives. Oncogene 1998 Dec 3;17(22):2889-99
acetyl-leucinal-nor-leucinal  0   Leucine/*analogs & derivatives. Oncogene 1998 Dec 3;17(22):2889-99
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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