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Progesterone Congeners

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Definition: Steroidal compounds related to PROGESTERONE, the major mammalian progestational hormone. Progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities.  GEN or unspecified; prefer specifics   
Examples Pregnenolone; Progesterone 		Other names Synthetic Progestogens; Synthetic Progestagens; Synthetic Progestins; Synthetic Progestational Hormones; Progestogens, Synthetic; Progestins, Synthetic; Progestin Analogues; Progestin Analogs; Progestational Hormones, Synthetic; Progestational Hormone Analogues; Progestational Hormone Analogs; Progestagens, Synthetic
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
chlorpromadinone acetate  0   *Acetates *Progesterone Congeners. Respirology 2001 Sep;6(3):265-7
norgestomet  25092-41-5 19-norpregn-4-ene-3,20-dione, 17-(acetyloxy)-11-methyl-, (11-beta)  *Pregnenediones Progesterone Congeners. Reprod Nutr Dev 1985;25(6):1029
clogestone  20047-75-0 6-chloro-3beta,17-dihydroxypregna-4,6-dien-20-one  *Pregnadienediols Progesterone Congeners.
methylestrenolone  514-61-4 estr-4-en-3-one, 17-beta-hydroxy-17-alpha-methyl  *Estrenes Progesterone Congeners.
17-ethinyl-11-oxa-testosterone  113555-47-8   Testosterone/*analogs & derivatives Progesterone Congeners. Steroids 1986;47(6):381
cymegesolate  72648-88-5 pregna-4,6-dien-20-one,17-(acetyloxy)-3-(3-cyclopentyl-1-oxopropoxy)-6-methyl-, (3-beta)  *Megestrol Acetate Progesterone Congeners. Sheng Li Hsueh Pao 1985;37(4):368
nomegestrol  58691-88-6 19-Norpregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl  Megestrol/*analogs & derivatives Antineoplastic Agents, Hormonal Progesterone Congeners. Rev Fr Gynecol Obstet 1985;80(10):757
3-keto-desogestrel  54048-10-1 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17-alpha)  *Desogestrel Progesterone Congeners.
Pharma Action Contraceptive Agents, Female 		J Steroid Biochem 1985;22(1):111NEXPLANON; IMPLANON
Oxolven  27806-42-4   *Estrenes Progesterone Congeners. Nord Vet Med 1983;35(10):360
nomegestrol acetate  58652-20-3   *Megestrol *Norpregnadienes Antineoplastic Agents, Hormonal Progesterone Congeners. Arzneimittelforsch 1983;33(5):710
16-alpha-ethyl-21-hydroxy-19-norpreg-4-ene-3,20-dione dodecanoate  67490-00-0 16-alpha-Ethyl-21-((1-oxododecyl)oxy)-19-norpregn-4-ene-3,20-dione  *Pregnenediones Progesterone Congeners. Contraception 1982;25(6):551
drospirenone  67392-87-4 Spiro(17H-dicyclopropa(6,7:15,16)cyclopenta(a)phenanthrene-17,2'(5'H)-furan)-3,5'(2H)-dione, 1,3',4',6,7,8,9,10,11,12,13,14,15,16,20,21-hexadecahydro-10,13-dimethyl-, (6R-(6alpha,7alpha,8beta,9alpha,10beta,13beta,14alpha,15alpha,16alpha,17beta))  *Androstenes Progesterone Congeners.
Pharma Action Aldosterone Antagonists 		J Chromatogr 1982;230(1):37YAZ
Duogestral  0   *Progesterone Congeners Estradiol Congeners. Minerva Ginecol 1981;33(5):429
norethindrone enanthate  3836-23-5 (17 alpha)-17-((1-oxoheptyl)oxy)-19-norpregn-4-en-20-yn-3-one  Norethindrone/*analogs & derivatives Progesterone Congeners.
Pharma Action Contraceptive Agents, Female ; Contraceptives, Oral, Synthetic 		Fertil Steril 1980;33(3):267
altrenogest  850-52-2 (17 beta)-17-hydroxy-17-(2-propenyl)estra-4,9,11-trien-3-one  Trenbolone Acetate/*analogs & derivatives Progesterone Congeners.
Pharma Action Progestins 		J Anim Sci 1979;49(6):1506; J Anim Sci 49(3):729;1979
17-alpha-hydroxy-progesterone caproate  630-56-8 17-((1-oxohexyl)oxy)pregn-4-ene-3,20-dione  *Hydroxyprogesterones Antineoplastic Agents Delayed-Action Preparations Progesterone Congeners.
Pharma Action Estradiol Antagonists ; Progestins 		Endokrinologie 73(1):33;1979; Ther Umsch 36(6):516;1979; Vopr Onkol 1979;25(10):53DELALUTIN; HYDROXYPROGESTERONE CAPROATE; MAKENA
16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione  24320-06-7 (16 alpha)-16-ethyl-21-hydroxy-19-norpregn- 4-ene-3,20-dione  *Pregnenediones Progesterone Congeners. Biochim Biophys Acta 585(1):24;1979; Eur J Cancer 1979;15(10):1181; Eur J Cancer 1979;15(5):785; J Endocrinol 80(2):15P;1979
proligestone  23873-85-0   Progesterone/*analogs & derivatives Progesterone Congeners. J Small Anim Pract 19(9):521;1978
anagestone  2740-52-5 17-hydroxy-6 alpha-methylpregn-4-en-20-one  *Pregnenes Progesterone Congeners. J Natl Cancer Inst 60(6):1351;1978
ethynerone  3124-93-4 21-chloro-17-hydroxy-19-nor-17 alpha-pregna-4,9-dien- 20-yn-3-one  *Norpregnadienes Progesterone Congeners. Exp Mol Pathol 30(2):279;1979; J Nat Can Inst 60(6):1351;1978
DU 41165  34184-58-2 6-fluoro-17-hydroxy-15-methylene-9 beta,10 alpha- pregna-4,6-diene-3,20-dione acetate  *Pregnenediones Progesterone Congeners. Acta Endocrinol 82(1):193;1976
demegestone  10116-22-0 17 alpha- methyl-19-demethylpregna-4,9-diene-3,20-dione  *Norprogesterones Progesterone Congeners. Rev Fr Gynecol Obstet 70(7-9):515;1975; Rev Fr Gynecol Obstet 71(10):595;1976
methylene-dehydroacetoxy-progesterone  805-84-5 17-hydroxy-16-methylene-delta 6-progesterone-17- acetate  *Hydroxyprogesterones Progesterone Congeners. Hormones Brain Function WL 300/601h:143;1971; Physiol Bohemoslov 21(4):647;1972
oxogestone phenylpropionate  16915-80-3 19-Norpregn-4-en-3-one, 20-(1-oxo-3-phenylpropoxy)-, (20R)  *Norpregnenes Progesterone Congeners. Acta Eur Fertil 3(1):37;1972
norgesterone  13563-60-5 17-beta-hydroxy-19-nor-17-alpha-pregna-5(10),20- dien-3-one  *Norpregnadienes Progesterone Congeners.
chloroethynyl norgestrel  2415-28-3 (17 alpha)-(+/-)-21-chloro-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one  Norgestrel/*analogs & derivatives Progesterone Congeners. J Natl Cancer Inst 60(6):1351;1978; Steroids 23(6):909;1974
edogestrone  809-01-8 17-hydroxy- 6-methylpregn-5-ene-3,20-dione cyclic 3-(ethylene acetal) acetate  *Pregnenediones Progesterone Congeners. Acta Endocrinol 75(2):385;1974
DU 41164  34542-22-8 6-fluoro-17-hydroxy-1 beta,2-methylene-9 beta,10- alpha-pregna-4,6-diene-3,20-dione 17-acetate  *Pregnenediones Progesterone Congeners. Acta Endocrinol 82(1):193;1976; Steroids 23(6):909;1974
GR 2-2132  52468-90-3 6,11 beta-dichloro-3 beta,17-dihydroxy-19-nor-4, 6-pregnadien-20-one-17-acetate-3 beta-benzoate  *Pregnadienediols Progesterone Congeners. Steroids 24(5):731;1974
cingestol  16915-71-2 19-nor-17 alpha-pregn-5-en-20-yn-17 beta-ol  *Norpregnenes Progesterone Congeners. Fertil Steril 24(8):578;1973; Reproduction 1(4):367;1974
clomegestone acetate  424-89-5 6-chloro-17-acetoxy-16 alpha-methylpregna-4,6- diene-3,20-dione  *Pregnenediones Progesterone Congeners. J Obstet Gynaecol Br Commonw 78(10):930;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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